Qing Chang

Renkai Wu, Yinghao Liu, Pengchen Liang et al.

Computer-aided diagnosis of skin diseases is an important tool. However, the interpretability of computer-aided diagnosis is currently poor. Dermatologists and patients cannot intuitively understand the learning and prediction process of neural networks, which will lead to a decrease in the credibility of computer-aided diagnosis. In addition, traditional methods need to be trained using negative samples in order to predict the presence or absence of a lesion, but medical data is often in short supply. In this paper, we propose a multiple high-order attention interaction model (MHA-UNet) for use in a highly explainable skin lesion segmentation task. MHA-UNet is able to obtain the presence or absence of a lesion by explainable reasoning without the need for training on negative samples. Specifically, we propose a high-order attention interaction mechanism that introduces squeeze attention to a higher level for feature attention. In addition, a multiple high-order attention interaction (MHAblock) module is proposed by combining the different features of different orders. For classifying the presence or absence of lesions, we conducted classification experiments on several publicly available datasets in the absence of negative samples, based on explainable reasoning about the interaction of 5 attention orders of MHAblock. The highest positive detection rate obtained from the experiments was 81.0% and the highest negative detection rate was 83.5%. For segmentation experiments, comparison experiments of the proposed method with 13 medical segmentation models and external validation experiments with 8 state-of-the-art models in three public datasets and our clinical dataset demonstrate the state-of-the-art performance of our model. The code is available from https://github.com/wurenkai/MHA-UNet.

Renkai Wu, Yinghao Liu, Pengchen Liang et al.

Traditionally for improving the segmentation performance of models, most approaches prefer to use adding more complex modules. And this is not suitable for the medical field, especially for mobile medical devices, where computationally loaded models are not suitable for real clinical environments due to computational resource constraints. Recently, state-space models (SSMs), represented by Mamba, have become a strong competitor to traditional CNNs and Transformers. In this paper, we deeply explore the key elements of parameter influence in Mamba and propose an UltraLight Vision Mamba UNet (UltraLight VM-UNet) based on this. Specifically, we propose a method for processing features in parallel Vision Mamba, named PVM Layer, which achieves excellent performance with the lowest computational load while keeping the overall number of processing channels constant. We conducted comparisons and ablation experiments with several state-of-the-art lightweight models on three skin lesion public datasets and demonstrated that the UltraLight VM-UNet exhibits the same strong performance competitiveness with parameters of only 0.049M and GFLOPs of 0.060. In addition, this study deeply explores the key elements of parameter influence in Mamba, which will lay a theoretical foundation for Mamba to possibly become a new mainstream module for lightweighting in the future. The code is available from https://github.com/wurenkai/UltraLight-VM-UNet .

Renkai Wu, Yinghao Liu, Pengchen Liang et al.

In the field of medical image segmentation, variant models based on Convolutional Neural Networks (CNNs) and Visual Transformers (ViTs) as the base modules have been very widely developed and applied. However, CNNs are often limited in their ability to deal with long sequences of information, while the low sensitivity of ViTs to local feature information and the problem of secondary computational complexity limit their development. Recently, the emergence of state-space models (SSMs), especially 2D-selective-scan (SS2D), has had an impact on the longtime dominance of traditional CNNs and ViTs as the foundational modules of visual neural networks. In this paper, we extend the adaptability of SS2D by proposing a High-order Vision Mamba UNet (H-vmunet) for medical image segmentation. Among them, the proposed High-order 2D-selective-scan (H-SS2D) progressively reduces the introduction of redundant information during SS2D operations through higher-order interactions. In addition, the proposed Local-SS2D module improves the learning ability of local features of SS2D at each order of interaction. We conducted comparison and ablation experiments on three publicly available medical image datasets (ISIC2017, Spleen, and CVC-ClinicDB), and the results all demonstrate the strong competitiveness of H-vmunet in medical image segmentation tasks. The code is available from https://github.com/wurenkai/H-vmunet .

Pengchen Liang, Bin Pu, Haishan Huang et al.

The rapid development of Vision Foundation Models (VFMs), particularly Vision Transformers (ViT) and Segment Anything Model (SAM), has sparked significant advances in the field of medical image analysis. These models have demonstrated exceptional capabilities in capturing long-range dependencies and achieving high generalization in segmentation tasks. However, adapting these large models to medical image analysis presents several challenges, including domain differences between medical and natural images, the need for efficient model adaptation strategies, and the limitations of small-scale medical datasets. This paper reviews the state-of-the-art research on the adaptation of VFMs to medical image segmentation, focusing on the challenges of domain adaptation, model compression, and federated learning. We discuss the latest developments in adapter-based improvements, knowledge distillation techniques, and multi-scale contextual feature modeling, and propose future directions to overcome these bottlenecks. Our analysis highlights the potential of VFMs, along with emerging methodologies such as federated learning and model compression, to revolutionize medical image analysis and enhance clinical applications. The goal of this work is to provide a comprehensive overview of current approaches and suggest key areas for future research that can drive the next wave of innovation in medical image segmentation.

Pengchen Liang, Leijun Shi, Huiping Yao et al.

Rapid bone scintigraphy is crucial for diagnosing skeletal disorders and detecting tumor metastases in children, as it shortens scan duration and reduces discomfort. However, accelerated acquisition often degrades image quality, impairing the visibility of fine anatomical details and potentially compromising diagnosis. To overcome this limitation, we introduce the first application of SAM-based semantic priors for medical image restoration, utilizing the Segment Anything Model (SAM) to enhance pediatric rapid bone scintigraphy. Our approach employs two cascaded networks, $f^{IR1}$ and $f^{IR2}$, supported by three specialized modules: a Semantic Prior Integration (SPI) module, a Semantic Knowledge Distillation (SKD) module, and a Semantic Consistency Module (SCM). The SPI and SKD modules inject domain-specific semantic cues from a fine-tuned SAM, while the SCM preserves coherent semantic feature representations across both cascaded stages. Moreover, we present RBS, a novel Rapid Bone Scintigraphy dataset comprising paired standard (20 cm/min) and rapid (40 cm/min) scans from 137 pediatric patients aged 0.5 - 16 years, making it the first dataset tailored for pediatric rapid bone scintigraphy restoration. Extensive experiments on both a public endoscopic dataset and our RBS dataset demonstrate that our method consistently surpasses existing techniques in PSNR, SSIM, FID, and LPIPS metrics.

Haishan Huang, Pengchen Liang, Naier Lin et al.

Nasopharyngeal carcinoma (NPC) patients often undergo radiotherapy and chemotherapy, which can lead to postoperative complications such as limited mouth opening and joint stiffness, particularly in recurrent cases that require re-surgery. These complications can affect airway function, making accurate postoperative airway risk assessment essential for managing patient care. Accurate segmentation of airway-related structures in postoperative CT scans is crucial for assessing these risks. This study introduces TopoWMamba (Topology-aware Wavelet Mamba), a novel segmentation model specifically designed to address the challenges of postoperative airway risk evaluation in recurrent NPC patients. TopoWMamba combines wavelet-based multi-scale feature extraction, state-space sequence modeling, and topology-aware modules to segment airway-related structures in CT scans robustly. By leveraging the Wavelet-based Mamba Block (WMB) for hierarchical frequency decomposition and the Snake Conv VSS (SCVSS) module to preserve anatomical continuity, TopoWMamba effectively captures both fine-grained boundaries and global structural context, crucial for accurate segmentation in complex postoperative scenarios. Through extensive testing on the NPCSegCT dataset, TopoWMamba achieves an average Dice score of 88.02%, outperforming existing models such as UNet, Attention UNet, and SwinUNet. Additionally, TopoWMamba is tested on the SegRap 2023 Challenge dataset, where it shows a significant improvement in trachea segmentation with a Dice score of 95.26%. The proposed model provides a strong foundation for automated segmentation, enabling more accurate postoperative airway risk evaluation.