Andrea Sebastiani

Elena Morotti, Davide Evangelista, Andrea Sebastiani et al.

This paper focuses on the development of a space-variant regularization model for solving an under-determined linear inverse problem. The case study is a medical image reconstruction from few-view tomographic noisy data. The primary objective of the proposed optimization model is to achieve a good balance between denoising and the preservation of fine details and edges, overcoming the performance of the popular and largely used Total Variation (TV) regularization through the application of appropriate pixel-dependent weights. The proposed strategy leverages the role of gradient approximations for the computation of the space-variant TV weights. For this reason, a convolutional neural network is designed, to approximate both the ground truth image and its gradient using an elastic loss function in its training. Additionally, the paper provides a theoretical analysis of the proposed model, showing the uniqueness of its solution, and illustrates a Chambolle-Pock algorithm tailored to address the specific problem at hand. This comprehensive framework integrates innovative regularization techniques with advanced neural network capabilities, demonstrating promising results in achieving high-quality reconstructions from low-sampled tomographic data.

Tatiana A. Bubba, Matteo Santacesaria, Andrea Sebastiani

Deep learning has emerged as a powerful tool for solving inverse problems in imaging, including computed tomography (CT). However, most approaches require paired training data with ground truth images, which can be difficult to obtain, e.g., in medical applications. We present TomoSelfDEQ, a self-supervised Deep Equilibrium (DEQ) framework for sparse-angle CT reconstruction that trains directly on undersampled measurements. We establish theoretical guarantees showing that, under suitable assumptions, our self-supervised updates match those of fully-supervised training with a loss including the (possibly non-unitary) forward operator like the CT forward map. Numerical experiments on sparse-angle CT data confirm this finding, also demonstrating that TomoSelfDEQ outperforms existing self-supervised methods, achieving state-of-the-art results with as few as 16 projection angles.

Pasquale Cascarano, Lorenzo Stacchio, Andrea Sebastiani et al.

In recent years, Diffusion Models have become the new state-of-the-art in deep generative modeling, ending the long-time dominance of Generative Adversarial Networks. Inspired by the Regularization by Denoising principle, we introduce an approach that integrates a Latent Diffusion Model, trained for the denoising task, into a variational framework using Half-Quadratic Splitting, exploiting its regularization properties. This approach, under appropriate conditions that can be easily met in various imaging applications, allows for reduced computational cost while achieving high-quality results. The proposed strategy, called Regularization by Latent Denoising (RELD), is then tested on a dataset of natural images, for image denoising, deblurring, and super-resolution tasks. The numerical experiments show that RELD is competitive with other state-of-the-art methods, particularly achieving remarkable results when evaluated using perceptual quality metrics.

Tatiana A. Bubba, Luca Ratti, Andrea Sebastiani

In this paper, we revisit a supervised learning approach based on unrolling, known as $Ψ$DONet, by providing a deeper microlocal interpretation for its theoretical analysis, and extending its study to the case of sparse-angle tomography. Furthermore, we refine the implementation of the original $Ψ$DONet considering special filters whose structure is specifically inspired by the streak artifact singularities characterizing tomographic reconstructions from incomplete data. This allows to considerably lower the number of (learnable) parameters while preserving (or even slightly improving) the same quality for the reconstructions from limited-angle data and providing a proof-of-concept for the case of sparse-angle tomographic data.

Pasquale Cascarano, Maria Colomba Comes, Andrea Sebastiani et al.

In fluorescence microscopy, Single Molecule Localization Microscopy (SMLM) techniques aim at localizing with high precision high density fluorescent molecules by stochastically activating and imaging small subsets of blinking emitters. Super Resolution (SR) plays an important role in this field since it allows to go beyond the intrinsic light diffraction limit. In this work, we propose a deep learning-based algorithm for precise molecule localization of high density frames acquired by SMLM techniques whose $\ell_{2}$-based loss function is regularized by positivity and $\ell_{0}$-based constraints. The $\ell_{0}$ is relaxed through its Continuous Exact $\ell_{0}$ (CEL0) counterpart. The arising approach, named DeepCEL0, is parameter-free, more flexible, faster and provides more precise molecule localization maps if compared to the other state-of-the-art methods. We validate our approach on both simulated and real fluorescence microscopy data.

Pasquale Cascarano, Elena Loli Piccolomini, Elena Morotti et al.

Blur and noise corrupting Computed Tomography (CT) images can hide or distort small but important details, negatively affecting the diagnosis. In this paper, we present a novel gradient-based Plug-and-Play algorithm, constructed on the Half-Quadratic Splitting scheme, and we apply it to restore CT images. In particular, we consider different schemes encompassing external and internal denoisers as priors, defined on the image gradient domain. The internal prior is based on the Total Variation functional. The external denoiser is implemented by a deep Convolutional Neural Network (CNN) trained on the gradient domain (and not on the image one, as in state-of-the-art works). We also prove a general fixed-point convergence theorem under weak assumptions on both internal and external denoisers. The experiments confirm the effectiveness of the proposed framework in restoring blurred noisy CT images, both in simulated and real medical settings. The achieved enhancements in the restored images are really remarkable, if compared to the results of many state-of-the-art methods.