Cheng‐Jin Du

Till Bretschneider, Cheng-Jin Du, Charles M. Elliott et al.

We present a computational approach for solving reaction-diffusion equations on evolving surfaces which have been obtained from cell image data. It is based on finite element spaces defined on surface triangulations extracted from time series of 3D images. A model for the transport of material between the subsequent surfaces is required where we postulate a velocity in normal direction. We apply the technique to image data obtained from a spreading neutrophil cell. By simulating FRAP experiments we investigate the impact of the evolving geometry on the recovery. We find that for idealised FRAP conditions, changes in membrane geometry, easily account for differences of $\times 10$ in recovery half-times, which shows that experimentalists must take great care when interpreting membrane photobleaching results. We also numerically solve an activator -- depleted substrate system and report on the effect of the membrane movement on the pattern evolution.

Zheng Lin, Nan Zhou, Chen-Xi Du et al.

Interactive segmentation aims to segment the specified target on the image with positive and negative clicks from users. Interactive ambiguity is a crucial issue in this field, which refers to the possibility of multiple compliant outcomes with the same clicks, such as selecting a part of an object versus the entire object, a single object versus a combination of multiple objects, and so on. The existing methods cannot provide intuitive guidance to the model, which leads to unstable output results and makes it difficult to meet the large-scale and efficient annotation requirements for specific targets in some scenarios. To bridge this gap, we introduce RefCut, a reference-based interactive segmentation framework designed to address part ambiguity and object ambiguity in segmenting specific targets. Users only need to provide a reference image and corresponding reference masks, and the model will be optimized based on them, which greatly reduces the interactive burden on users when annotating a large number of such targets. In addition, to enrich these two kinds of ambiguous data, we propose a new Target Disassembly Dataset which contains two subsets of part disassembly and object disassembly for evaluation. In the combination evaluation of multiple datasets, our RefCut achieved state-of-the-art performance. Extensive experiments and visualized results demonstrate that RefCut advances the field of intuitive and controllable interactive segmentation. Our code will be publicly available and the demo video is in https://www.lin-zheng.com/refcut.