Jiakai Zhang

Yingjun Shen, Haizhao Dai, Qihe Chen et al.

Foundation models in computer vision have demonstrated exceptional performance in zero-shot and few-shot tasks by extracting multi-purpose features from large-scale datasets through self-supervised pre-training methods. However, these models often overlook the severe corruption in cryogenic electron microscopy (cryo-EM) images by high-level noises. We introduce DRACO, a Denoising-Reconstruction Autoencoder for CryO-EM, inspired by the Noise2Noise (N2N) approach. By processing cryo-EM movies into odd and even images and treating them as independent noisy observations, we apply a denoising-reconstruction hybrid training scheme. We mask both images to create denoising and reconstruction tasks. For DRACO's pre-training, the quality of the dataset is essential, we hence build a high-quality, diverse dataset from an uncurated public database, including over 270,000 movies or micrographs. After pre-training, DRACO naturally serves as a generalizable cryo-EM image denoiser and a foundation model for various cryo-EM downstream tasks. DRACO demonstrates the best performance in denoising, micrograph curation, and particle picking tasks compared to state-of-the-art baselines.

Rahul Mitra, Jiakai Zhang, Sanath Narayan et al.

We propose a convolutional neural network (ConvNet) based approach for learning local image descriptors which can be used for significantly improved patch matching and 3D reconstructions. A multi-resolution ConvNet is used for learning keypoint descriptors. We also propose a new dataset consisting of an order of magnitude more number of scenes, images, and positive and negative correspondences compared to the currently available Multi-View Stereo (MVS) [18] dataset. The new dataset also has better coverage of the overall viewpoint, scale, and lighting changes in comparison to the MVS dataset. We evaluate our approach on publicly available datasets, such as Oxford Affine Covariant Regions Dataset (ACRD) [12], MVS [18], Synthetic [6] and Strecha [15] datasets to quantify the image descriptor performance. Scenes from the Oxford ACRD, MVS and Synthetic datasets are used for evaluating the patch matching performance of the learnt descriptors while the Strecha dataset is used to evaluate the 3D reconstruction task. Experiments show that the proposed descriptor outperforms the current state-of-the-art descriptors in both the evaluation tasks.