Yuxuan Zheng

Yangqing Zheng, Shunqi Mao, Dingxin Zhang et al.

In the realm of embodied intelligence, the evolution of large language models (LLMs) has markedly enhanced agent decision making. Consequently, researchers have begun exploring agent performance in dynamically changing high-risk scenarios, i.e., fire, flood, and wind scenarios in the HAZARD benchmark. Under these extreme conditions, the delay in decision making emerges as a crucial yet insufficiently studied issue. We propose a Time Conversion Mechanism (TCM) that translates inference delays in decision-making into equivalent simulation frames, thus aligning cognitive and physical costs under a single FPS-based metric. By extending HAZARD with Respond Latency (RL) and Latency-to-Action Ratio (LAR), we deliver a fully latency-aware evaluation protocol. Moreover, we present the Rapid-Reflex Async-Reflect Agent (RRARA), which couples a lightweight LLM-guided feedback module with a rule-based agent to enable immediate reactive behaviors and asynchronous reflective refinements in situ. Experiments on HAZARD show that RRARA substantially outperforms existing baselines in latency-sensitive scenarios.

Shentong Mo, Xi Fu, Chenyang Hong et al.

In the genome biology research, regulatory genome modeling is an important topic for many regulatory downstream tasks, such as promoter classification, transaction factor binding sites prediction. The core problem is to model how regulatory elements interact with each other and its variability across different cell types. However, current deep learning methods often focus on modeling genome sequences of a fixed set of cell types and do not account for the interaction between multiple regulatory elements, making them only perform well on the cell types in the training set and lack the generalizability required in biological applications. In this work, we propose a simple yet effective approach for pre-training genome data in a multi-modal and self-supervised manner, which we call GeneBERT. Specifically, we simultaneously take the 1d sequence of genome data and a 2d matrix of (transcription factors x regions) as the input, where three pre-training tasks are proposed to improve the robustness and generalizability of our model. We pre-train our model on the ATAC-seq dataset with 17 million genome sequences. We evaluate our GeneBERT on regulatory downstream tasks across different cell types, including promoter classification, transaction factor binding sites prediction, disease risk estimation, and splicing sites prediction. Extensive experiments demonstrate the effectiveness of multi-modal and self-supervised pre-training for large-scale regulatory genomics data.