Zijing Li

Zhongwei Yu, Rasul Tutunov, Alexandre Max Maraval et al.

Traditional scientific discovery relies on an iterative hypothesise-experiment-refine cycle that has driven progress for centuries, but its intuitive, ad-hoc implementation often wastes resources, yields inefficient designs, and misses critical insights. This tutorial presents Bayesian Optimisation (BO), a principled probability-driven framework that formalises and automates this core scientific cycle. BO uses surrogate models (e.g., Gaussian processes) to model empirical observations as evolving hypotheses, and acquisition functions to guide experiment selection, balancing exploitation of known knowledge and exploration of uncharted domains to eliminate guesswork and manual trial-and-error. We first frame scientific discovery as an optimisation problem, then unpack BO's core components, end-to-end workflows, and real-world efficacy via case studies in catalysis, materials science, organic synthesis, and molecule discovery. We also cover critical technical extensions for scientific applications, including batched experimentation, heteroscedasticity, contextual optimisation, and human-in-the-loop integration. Tailored for a broad audience, this tutorial bridges AI advances in BO with practical natural science applications, offering tiered content to empower cross-disciplinary researchers to design more efficient experiments and accelerate principled scientific discovery.

Ziqi Zhou, Yifan Hu, Yufei Song et al.

Recent studies reveal the vulnerability of the image segmentation foundation model SAM to adversarial examples. Its successor, SAM2, has attracted significant attention due to its strong generalization capability in video segmentation. However, its robustness remains unexplored, and it is unclear whether existing attacks on SAM can be directly transferred to SAM2. In this paper, we first analyze the performance gap of existing attacks between SAM and SAM2 and highlight two key challenges arising from their architectural differences: directional guidance from the prompt and semantic entanglement across consecutive frames. To address these issues, we propose UAP-SAM2, the first cross-prompt universal adversarial attack against SAM2 driven by dual semantic deviation. For cross-prompt transferability, we begin by designing a target-scanning strategy that divides each frame into k regions, each randomly assigned a prompt, to reduce prompt dependency during optimization. For effectiveness, we design a dual semantic deviation framework that optimizes a UAP by distorting the semantics within the current frame and disrupting the semantic consistency across consecutive frames. Extensive experiments on six datasets across two segmentation tasks demonstrate the effectiveness of the proposed method for SAM2. The comparative results show that UAP-SAM2 significantly outperforms state-of-the-art (SOTA) attacks by a large margin.