Qiang Su

Letian Yi, Tingpeng Zhang, Mingyuan Zhou et al.

Reconstructing full fields from extremely sparse and random measurements is a longstanding ill-posed inverse problem. A powerful framework for addressing such challenges is hierarchical probabilistic modeling, where uncertainty is represented by intermediate variables and resolved through marginalization during inference. Inspired by this principle, we propose Cascaded Sensing (Cas-Sensing), a hierarchical reconstruction framework that integrates an autoencoder-diffusion cascade. First, a neural operator-based functional autoencoder reconstructs the dominant structures of the original field - including large-scale components and geometric boundaries - from arbitrary sparse inputs, serving as an intermediate variable. Then, a conditional diffusion model, trained with a mask-cascade strategy, generates fine-scale details conditioned on these large-scale structures. To further enhance fidelity, measurement consistency is enforced via the manifold constrained gradient based on Bayesian posterior sampling during the generation process. This cascaded pipeline substantially alleviates ill-posedness, delivering accurate and robust reconstructions. Experiments on both simulation and real-world datasets demonstrate that Cas-Sensing generalizes well across varying sensor configurations and geometric boundaries, making it a promising tool for practical deployment in scientific and engineering applications.

Yongping Zhai, Xiaoxi Fu, Qiang Su et al.

Autofocus is necessary for high-throughput and real-time scanning in microscopic imaging. Traditional methods rely on complex hardware or iterative hill-climbing algorithms. Recent learning-based approaches have demonstrated remarkable efficacy in a one-shot setting, avoiding hardware modifications or iterative mechanical lens adjustments. However, in this paper, we highlight a significant challenge that the richness of image content can significantly affect autofocus performance. When the image content is sparse, previous autofocus methods, whether traditional climbing-hill or learning-based, tend to fail. To tackle this, we propose a content-importance-based solution, named SparseFocus, featuring a novel two-stage pipeline. The first stage measures the importance of regions within the image, while the second stage calculates the defocus distance from selected important regions. To validate our approach and benefit the research community, we collect a large-scale dataset comprising millions of labelled defocused images, encompassing both dense, sparse and extremely sparse scenarios. Experimental results show that SparseFocus surpasses existing methods, effectively handling all levels of content sparsity. Moreover, we integrate SparseFocus into our Whole Slide Imaging (WSI) system that performs well in real-world applications. The code and dataset will be made available upon the publication of this paper.