Mingye Gao

Tianhua Zhang, Jiaxin Ge, Hongyin Luo et al. · mit

How can we perform computations over natural language representations to solve tasks that require symbolic and numeric reasoning? We propose natural language embedded programs (NLEP) as a unifying framework for addressing math/symbolic reasoning, natural language understanding, and instruction following tasks. Our approach prompts a language model to generate full Python programs that define functions over data structures which contain natural language representations of structured knowledge. A Python interpreter then executes the generated code and prints the output. Despite using a task-general prompt, we find that this approach can improve upon strong baselines across a range of different tasks including math and symbolic reasoning, text classification, question answering, and instruction following. We found that the generated programs are interpretable since they outline the exact reasoning process followed by the program interpreter.

Shan Chen, Mingye Gao, Kuleen Sasse et al. · harvard

Background: Large language models (LLMs) are trained to follow directions, but this introduces a vulnerability to blindly comply with user requests even if they generate wrong information. In medicine, this could accelerate the generation of misinformation that impacts human well-being. Objectives/Methods: We analyzed compliance to requests to generate misleading content about medications in settings where models know the request is illogical. We investigated whether in-context directions and instruction-tuning of LLMs to prioritize logical reasoning over compliance reduced misinformation risk. Results: While all frontier LLMs complied with misinformation requests, both prompt-based and parameter-based approaches can improve the detection of logic flaws in requests and prevent the dissemination of medical misinformation. Conclusion: Shifting LLMs to prioritize logic over compliance could reduce risks of exploitation for medical misinformation.

Jack Gallifant, Shan Chen, Pedro Moreira et al.

Medical knowledge is context-dependent and requires consistent reasoning across various natural language expressions of semantically equivalent phrases. This is particularly crucial for drug names, where patients often use brand names like Advil or Tylenol instead of their generic equivalents. To study this, we create a new robustness dataset, RABBITS, to evaluate performance differences on medical benchmarks after swapping brand and generic drug names using physician expert annotations. We assess both open-source and API-based LLMs on MedQA and MedMCQA, revealing a consistent performance drop ranging from 1-10\%. Furthermore, we identify a potential source of this fragility as the contamination of test data in widely used pre-training datasets. All code is accessible at https://github.com/BittermanLab/RABBITS, and a HuggingFace leaderboard is available at https://huggingface.co/spaces/AIM-Harvard/rabbits-leaderboard.

Zhantao Chen, Cong Wang, Mingye Gao et al.

The development of X-ray Free Electron Lasers (XFELs) has opened numerous opportunities to probe atomic structure and ultrafast dynamics of various materials. Single Particle Imaging (SPI) with XFELs enables the investigation of biological particles in their natural physiological states with unparalleled temporal resolution, while circumventing the need for cryogenic conditions or crystallization. However, reconstructing real-space structures from reciprocal-space x-ray diffraction data is highly challenging due to the absence of phase and orientation information, which is further complicated by weak scattering signals and considerable fluctuations in the number of photons per pulse. In this work, we present an end-to-end, self-supervised machine learning approach to recover particle orientations and estimate reciprocal space intensities from diffraction images only. Our method demonstrates great robustness under demanding experimental conditions with significantly enhanced reconstruction capabilities compared with conventional algorithms, and signifies a paradigm shift in SPI as currently practiced at XFELs.

Mahsa Khoshnoodi, Vinija Jain, Mingye Gao et al.

Despite the crucial importance of accelerating text generation in large language models (LLMs) for efficiently producing content, the sequential nature of this process often leads to high inference latency, posing challenges for real-time applications. Various techniques have been proposed and developed to address these challenges and improve efficiency. This paper presents a comprehensive survey of accelerated generation techniques in autoregressive language models, aiming to understand the state-of-the-art methods and their applications. We categorize these techniques into several key areas: speculative decoding, early exiting mechanisms, and non-autoregressive methods. We discuss each category's underlying principles, advantages, limitations, and recent advancements. Through this survey, we aim to offer insights into the current landscape of techniques in LLMs and provide guidance for future research directions in this critical area of natural language processing.

Xiaomin Li, Mingye Gao, Zhiwei Zhang et al.

Reinforcement Learning from Human Feedback (RLHF) is commonly employed to tailor models to human preferences, especially to improve the safety of outputs from large language models (LLMs). Traditionally, this method depends on selecting preferred responses from pairs. However, due to the variability in human opinions and the challenges in directly comparing two responses, there is an increasing trend towards fine-grained annotation approaches that evaluate responses using multiple targeted metrics or rules. The challenge lies in efficiently choosing and applying these rules to handle the diverse range of preference data. In this paper, we propose a dynamic method that adaptively selects the most important rules for each response pair. We introduce a mathematical framework that utilizes the maximum discrepancy across paired responses and demonstrate theoretically that this approach maximizes the mutual information between the rule-based annotations and the underlying true preferences. We then train an 8B reward model using this adaptively labeled preference dataset and assess its efficacy using RewardBench. As of January 25, 2025, our model achieved the highest safety performance on the leaderboard, surpassing various larger models.

Xiaomin Li, Xupeng Chen, Jingxuan Fan et al.

The safety alignment of large language models (LLMs) often relies on reinforcement learning from human feedback (RLHF), which requires human annotations to construct preference datasets. Given the challenge of assigning overall quality scores to data, recent works increasingly adopt fine-grained ratings based on multiple safety rules. In this paper, we discover a robust phenomenon: Rules with higher rating entropy tend to have lower accuracy in distinguishing human-preferred responses. Exploiting this insight, we propose ENCORE, a simple entropy-guided method to compose multi-head rewards by penalizing rules with high rating entropy. Theoretically, we show that such rules yield negligible weights under the Bradley-Terry loss during weight optimization, naturally justifying their penalization. Empirically, ENCORE consistently outperforms strong baselines, including random and uniform weighting, single-head Bradley-Terry, and LLM-as-a-judge, etc. on RewardBench safety tasks. Our method is completely training-free, generally applicable across datasets, and retains interpretability, making it a practical and effective approach for multi-attribute reward modeling.

Mingye Gao, Aman Varshney, Shan Chen et al.

Cancer clinical trials often face challenges in recruitment and engagement due to a lack of participant-facing informational and educational resources. This study investigated the potential of Large Language Models (LLMs), specifically GPT4, in generating patient-friendly educational content from clinical trial informed consent forms. Using data from ClinicalTrials.gov, we employed zero-shot learning for creating trial summaries and one-shot learning for developing multiple-choice questions, evaluating their effectiveness through patient surveys and crowdsourced annotation. Results showed that GPT4-generated summaries were both readable and comprehensive, and may improve patients' understanding and interest in clinical trials. The multiple-choice questions demonstrated high accuracy and agreement with crowdsourced annotators. For both resource types, hallucinations were identified that require ongoing human oversight. The findings demonstrate the potential of LLMs "out-of-the-box" to support the generation of clinical trial education materials with minimal trial-specific engineering, but implementation with a human-in-the-loop is still needed to avoid misinformation risks.

Shan Chen, Jack Gallifant, Mingye Gao et al.

Large language models (LLMs) are increasingly essential in processing natural languages, yet their application is frequently compromised by biases and inaccuracies originating in their training data. In this study, we introduce Cross-Care, the first benchmark framework dedicated to assessing biases and real world knowledge in LLMs, specifically focusing on the representation of disease prevalence across diverse demographic groups. We systematically evaluate how demographic biases embedded in pre-training corpora like $ThePile$ influence the outputs of LLMs. We expose and quantify discrepancies by juxtaposing these biases against actual disease prevalences in various U.S. demographic groups. Our results highlight substantial misalignment between LLM representation of disease prevalence and real disease prevalence rates across demographic subgroups, indicating a pronounced risk of bias propagation and a lack of real-world grounding for medical applications of LLMs. Furthermore, we observe that various alignment methods minimally resolve inconsistencies in the models' representation of disease prevalence across different languages. For further exploration and analysis, we make all data and a data visualization tool available at: www.crosscare.net.

Yung-Sung Chuang, Mingye Gao, Hongyin Luo et al.

Automatic detection of toxic language plays an essential role in protecting social media users, especially minority groups, from verbal abuse. However, biases toward some attributes, including gender, race, and dialect, exist in most training datasets for toxicity detection. The biases make the learned models unfair and can even exacerbate the marginalization of people. Considering that current debiasing methods for general natural language understanding tasks cannot effectively mitigate the biases in the toxicity detectors, we propose to use invariant rationalization (InvRat), a game-theoretic framework consisting of a rationale generator and a predictor, to rule out the spurious correlation of certain syntactic patterns (e.g., identity mentions, dialect) to toxicity labels. We empirically show that our method yields lower false positive rate in both lexical and dialectal attributes than previous debiasing methods.

Hongyin Luo, Shang-Wen Li, Mingye Gao et al.

Pretrained language models have significantly improved the performance of downstream language understanding tasks, including extractive question answering, by providing high-quality contextualized word embeddings. However, training question answering models still requires large amounts of annotated data for specific domains. In this work, we propose a cooperative self-training framework, RGX, for automatically generating more non-trivial question-answer pairs to improve model performance. RGX is built upon a masked answer extraction task with an interactive learning environment containing an answer entity Recognizer, a question Generator, and an answer eXtractor. Given a passage with a masked entity, the generator generates a question around the entity, and the extractor is trained to extract the masked entity with the generated question and raw texts. The framework allows the training of question generation and answering models on any text corpora without annotation. Experiment results show that RGX outperforms the state-of-the-art (SOTA) pretrained language models and transfer learning approaches on standard question-answering benchmarks, and yields the new SOTA performance under given model size and transfer learning settings.