Dan Luo

Dongwen Luo

Power grid load scheduling is a critical task that ensures the balance between electricity generation and consumption while minimizing operational costs and maintaining grid stability. Traditional optimization methods often struggle with the dynamic and stochastic nature of power systems, especially when faced with renewable energy sources and fluctuating demand. This paper proposes a reinforcement learning (RL) approach using a Markov Decision Process (MDP) framework to address the challenges of dynamic load scheduling. The MDP is defined by a state space representing grid conditions, an action space covering control operations like generator adjustments and storage management, and a reward function balancing economic efficiency and system reliability. We investigate the application of various RL algorithms, from basic Q-Learning to more advanced Deep Q-Networks (DQN) and Actor-Critic methods, to determine optimal scheduling policies. The proposed approach is evaluated through a simulated power grid environment, demonstrating its potential to improve scheduling efficiency and adapt to variable demand patterns. Our results show that the RL-based method provides a robust and scalable solution for real-time load scheduling, contributing to the efficient management of modern power grids.

Jinming Xing, Dongwen Luo, Qisen Cheng et al.

Fuzzy Graph Attention Network (FGAT), which combines Fuzzy Rough Sets and Graph Attention Networks, has shown promise in tasks requiring robust graph-based learning. However, existing models struggle to effectively capture dependencies from multiple perspectives, limiting their ability to model complex data. To address this gap, we propose the Multi-view Fuzzy Graph Attention Network (MFGAT), a novel framework that constructs and aggregates multi-view information using a specially designed Transformation Block. This block dynamically transforms data from multiple aspects and aggregates the resulting representations via a weighted sum mechanism, enabling comprehensive multi-view modeling. The aggregated information is fed into FGAT to enhance fuzzy graph convolutions. Additionally, we introduce a simple yet effective learnable global pooling mechanism for improved graph-level understanding. Extensive experiments on graph classification tasks demonstrate that MFGAT outperforms state-of-the-art baselines, underscoring its effectiveness and versatility.

Dan Luo, Jinyu Zhou, Le Xu et al.

Predicting drug-target binding affinity (DTA) is essential for identifying potential therapeutic candidates in drug discovery. However, most existing models rely heavily on static protein structures, often overlooking the dynamic nature of proteins, which is crucial for capturing conformational flexibility that will be beneficial for protein binding interactions. We introduce DynamicDTA, an innovative deep learning framework that incorporates static and dynamic protein features to enhance DTA prediction. The proposed DynamicDTA takes three types of inputs, including drug sequence, protein sequence, and dynamic descriptors. A molecular graph representation of the drug sequence is generated and subsequently processed through graph convolutional network, while the protein sequence is encoded using dilated convolutions. Dynamic descriptors, such as root mean square fluctuation, are processed through a multi-layer perceptron. These embedding features are fused with static protein features using cross-attention, and a tensor fusion network integrates all three modalities for DTA prediction. Extensive experiments on three datasets demonstrate that DynamicDTA achieves by at least 3.4% improvement in RMSE score with comparison to seven state-of-the-art baseline methods. Additionally, predicting novel drugs for Human Immunodeficiency Virus Type 1 and visualizing the docking complexes further demonstrates the reliability and biological relevance of DynamicDTA.