Michael J. Wan

Shaotong Zhu, Michael Wan, Elaheh Hatamimajoumerd et al.

We present an end-to-end computer vision pipeline to detect non-nutritive sucking (NNS) -- an infant sucking pattern with no nutrition delivered -- as a potential biomarker for developmental delays, using off-the-shelf baby monitor video footage. One barrier to clinical (or algorithmic) assessment of NNS stems from its sparsity, requiring experts to wade through hours of footage to find minutes of relevant activity. Our NNS activity segmentation algorithm solves this problem by identifying periods of NNS with high certainty -- up to 94.0\% average precision and 84.9\% average recall across 30 heterogeneous 60 s clips, drawn from our manually annotated NNS clinical in-crib dataset of 183 hours of overnight baby monitor footage from 19 infants. Our method is based on an underlying NNS action recognition algorithm, which uses spatiotemporal deep learning networks and infant-specific pose estimation, achieving 94.9\% accuracy in binary classification of 960 2.5 s balanced NNS vs. non-NNS clips. Tested on our second, independent, and public NNS in-the-wild dataset, NNS recognition classification reaches 92.3\% accuracy, and NNS segmentation achieves 90.8\% precision and 84.2\% recall.

Xiaofei Huang, Michael Wan, Lingfei Luan et al.

Bilateral postural symmetry plays a key role as a potential risk marker for autism spectrum disorder (ASD) and as a symptom of congenital muscular torticollis (CMT) in infants, but current methods of assessing symmetry require laborious clinical expert assessments. In this paper, we develop a computer vision based infant symmetry assessment system, leveraging 3D human pose estimation for infants. Evaluation and calibration of our system against ground truth assessments is complicated by our findings from a survey of human ratings of angle and symmetry, that such ratings exhibit low inter-rater reliability. To rectify this, we develop a Bayesian estimator of the ground truth derived from a probabilistic graphical model of fallible human raters. We show that the 3D infant pose estimation model can achieve 68% area under the receiver operating characteristic curve performance in predicting the Bayesian aggregate labels, compared to only 61% from a 2D infant pose estimation model and 60% from a 3D adult pose estimation model, highlighting the importance of 3D poses and infant domain knowledge in assessing infant body symmetry. Our survey analysis also suggests that human ratings are susceptible to higher levels of bias and inconsistency, and hence our final 3D pose-based symmetry assessment system is calibrated but not directly supervised by Bayesian aggregate human ratings, yielding higher levels of consistency and lower levels of inter-limb assessment bias.

Michael Wan, Xiaofei Huang, Bethany Tunik et al.

We apply computer vision pose estimation techniques developed expressly for the data-scarce infant domain to the study of torticollis, a common condition in infants for which early identification and treatment is critical. Specifically, we use a combination of facial landmark and body joint estimation techniques designed for infants to estimate a range of geometric measures pertaining to face and upper body symmetry, drawn from an array of sources in the physical therapy and ophthalmology research literature in torticollis. We gauge performance with a range of metrics and show that the estimates of most these geometric measures are successful, yielding strong to very strong Spearman's $ρ$ correlation with ground truth values. Furthermore, we show that these estimates, derived from pose estimation neural networks designed for the infant domain, cleanly outperform estimates derived from more widely known networks designed for the adult domain

Sai Kumar Reddy Manne, Brendan Martin, Tyler Roy et al.

Osteoclast cell image analysis plays a key role in osteoporosis research, but it typically involves extensive manual image processing and hand annotations by a trained expert. In the last few years, a handful of machine learning approaches for osteoclast image analysis have been developed, but none have addressed the full instance segmentation task required to produce the same output as that of the human expert led process. Furthermore, none of the prior, fully automated algorithms have publicly available code, pretrained models, or annotated datasets, inhibiting reproduction and extension of their work. We present a new dataset with ~2*10^5 expert annotated mouse osteoclast masks, together with a deep learning instance segmentation method which works for both in vitro mouse osteoclast cells on plastic tissue culture plates and human osteoclast cells on bone chips. To our knowledge, this is the first work to automate the full osteoclast instance segmentation task. Our method achieves a performance of 0.82 mAP_0.5 (mean average precision at intersection-over-union threshold of 0.5) in cross validation for mouse osteoclasts. We present a novel nuclei-aware osteoclast instance segmentation training strategy (NOISe) based on the unique biology of osteoclasts, to improve the model's generalizability and boost the mAP_0.5 from 0.60 to 0.82 on human osteoclasts. We publish our annotated mouse osteoclast image dataset, instance segmentation models, and code at github.com/michaelwwan/noise to enable reproducibility and to provide a public tool to accelerate osteoporosis research.