Neguine Rezaii

Rui He, Claudio Palominos, Samuele Vallisa et al.

Isolated word meanings are inherently uncertain. This uncertainty reduces when they are combined and anchored in context. We propose that grammar compresses meaning uncertainty cross-linguistically, which is reflected in brain and selectively disrupted in disorders. Compression was operationalized as the relative difference between non-contextual surprisal estimated from lexical frequency, and contextual surprisal from grammar-sensitive models. In narratives from 20 languages, contextual surprisal reduced frequency-based surprisal. This reduction closely tracked the surprisal cost of reversing word order, and scaled with richer, non-redundant lexis as organized by more complex but optimal dependency structure. During fMRI, surprisal and its reduction explained BOLD activity for comprehension and production in overlapping but distinct regions. Uncertainty reduction was significantly attenuated in aphasia, dementia, and schizophrenia, but remained intact where primary deficit is not language. These findings position uncertainty reduction via grammar as a foundational concept that illuminates principles, brain basis, and disruptions of language.

Neguine Rezaii

As speakers turn their thoughts into sentences, they maintain a balance between the complexity of words and syntax. However, it is unclear whether this syntax-lexicon tradeoff is unique to the spoken language production that is under the pressure of rapid online processing. Alternatively, it is possible that the tradeoff is a basic property of language irrespective of the modality of production. This work evaluates the relationship between the complexity of words and syntactic rules in the written language of neurotypical individuals on three different topics. We found that similar to speaking, constructing sentences in writing involves a tradeoff between the complexity of the lexical and syntactic items. We also show that the reduced online processing demands during writing allows for retrieving more complex words at the cost of incorporating simpler syntax. This work further highlights the role of accessibility of the elements of a sentence as the driving force in the emergence of the syntax-lexicon tradeoff.

Pedram Fard, Alaleh Azhir, Neguine Rezaii et al.

Artificial intelligence in medicine is built to serve the average patient. By minimizing error across large datasets, most systems deliver strong aggregate accuracy yet falter at the margins: patients with rare variants, multimorbidity, or underrepresented demographics. This average patient fallacy erodes both equity and trust. We propose a different design: a multi-agent ecosystem for N-of-1 decision support. In this environment, agents clustered by organ systems, patient populations, and analytic modalities draw on a shared library of models and evidence synthesis tools. Their results converge in a coordination layer that weighs reliability, uncertainty, and data density before presenting the clinician with a decision-support packet: risk estimates bounded by confidence ranges, outlier flags, and linked evidence. Validation shifts from population averages to individual reliability, measured by error in low-density regions, calibration in the small, and risk--coverage trade-offs. Anticipated challenges include computational demands, automation bias, and regulatory fit, addressed through caching strategies, consensus checks, and adaptive trial frameworks. By moving from monolithic models to orchestrated intelligence, this approach seeks to align medical AI with the first principle of medicine: care that is transparent, equitable, and centered on the individual.