Viswam Nathan

Hao Zhou, Simon A. Lee, Cyrus Tanade et al.

Biosignals acquired from different locations on the body often provide temporally ordered views of the same underlying physiological process. However, most existing self supervised learning methods treat these signals as interchangeable views, overlooking the directional temporal dynamics that link them. A canonical example is the relationship between electrocardiography (ECG), which captures the electrical activation initiating each heartbeat, and photoplethysmography (PPG), which records the resulting peripheral pulse delayed by vascular dynamics. To capture this structured relationship, we introduce xMAE, a biosignal pretraining framework that leverages masked cross modal reconstruction across temporally ordered biosignals as a training time constraint to encourage physiologically meaningful timing structure in the learned representations. We show that pretraining with xMAE yields representations that outperform both unimodal and multimodal baselines on 15 of 19 downstream tasks, including cardiovascular outcome prediction, abnormal laboratory test detection, sleep staging, and demographic inference, while generalizing across devices, body locations, and acquisition settings. Further analysis suggests that the ECG PPG timing structure is reflected in the learned PPG representations. More broadly, xMAE demonstrates the effectiveness of incorporating temporal structure into multimodal pretraining when signals observe different stages of a shared underlying process. Code is available at https://github.com/hzhou3/xMAE.

Yunsung Chung, Keum San Chun, Migyeong Gwak et al.

Advances in wearable computing and AI have increased interest in leveraging PPG for health monitoring over the past decade. One of the biggest challenges in developing health algorithms based on such biosignals is the sparsity of clinical labels, which makes biosignals temporally distant from lab draws less reliable for supervision. To address this problem, we introduce a simple training strategy that learns a biomarker-specific decay of sample weight over the time gap between a segment and its ground truth label and uses this weight in the loss with a regularizer to prevent trivial solutions. On smartwatch PPG from 450 participants across 10 biomarkers, the approach improves over baselines. In the subject-wise setting, the proposed approach averages 0.715 AUPRC, compared to 0.674 for a fine-tuned self-supervised baseline and 0.626 for a feature-based Random Forest. A comparison of four decay families shows that a simple linear decay function is most robust on average. Beyond accuracy, the learned decay rates summarize how quickly each biomarker's PPG evidence becomes stale, providing an interpretable view of temporal sensitivity.

Simon A. Lee, Cyrus Tanade, Hao Zhou et al.

Wearable sensors provide abundant physiological time series, yet the principles governing their predictive utility remain unclear. We hypothesize that temporal resolution is a fundamental axis of representation learning, with different clinical and behavioral outcomes relying on structure at distinct scales. To test this resolution hypothesis, we introduce HiMAE (Hierarchical Masked Autoencoder), a self supervised framework that combines masked autoencoding with a hierarchical convolutional encoder decoder. HiMAE produces multi resolution embeddings that enable systematic evaluation of which temporal scales carry predictive signal, transforming resolution from a hyperparameter into a probe for interpretability. Across classification, regression, and generative benchmarks, HiMAE consistently outperforms state of the art foundation models that collapse scale, while being orders of magnitude smaller. HiMAE is an efficient representation learner compact enough to run entirely on watch, achieving sub millisecond inference on smartwatch class CPUs for true edge inference. Together, these contributions position HiMAE as both an efficient self supervised learning method and a discovery tool for scale sensitive structure in wearable health.