Yuxiang Li

Haoran Wang, Xuanyi Zhang, Shuangsang Fang et al.

Recent advancements in single-cell multi-omics, particularly RNA-seq, have provided profound insights into cellular heterogeneity and gene regulation. While pre-trained language model (PLM) paradigm based single-cell foundation models have shown promise, they remain constrained by insufficient integration of in-depth individual profiles and neglecting the influence of noise within multi-modal data. To address both issues, we propose an Open-world Language Knowledge-Aided Robust Single-Cell Foundation Model (OKR-CELL). It is built based on a cross-modal Cell-Language pre-training framework, which comprises two key innovations: (1) leveraging Large Language Models (LLMs) based workflow with retrieval-augmented generation (RAG) enriches cell textual descriptions using open-world knowledge; (2) devising a Cross-modal Robust Alignment (CRA) objective that incorporates sample reliability assessment, curriculum learning, and coupled momentum contrastive learning to strengthen the model's resistance to noisy data. After pretraining on 32M cell-text pairs, OKR-CELL obtains cutting-edge results across 6 evaluation tasks. Beyond standard benchmarks such as cell clustering, cell-type annotation, batch-effect correction, and few-shot annotation, the model also demonstrates superior performance in broader multi-modal applications, including zero-shot cell-type annotation and bidirectional cell-text retrieval.

Yuxiang Li, Kun Chen, Jiancheng Wang et al.

Heterogeneous multi-robot systems feature significant adaptability for complex environments. However, effective collaboration that fully exploits the robots' potential remains a core challenge. This paper proposes a decentralized collaborative framework for heterogeneous multi-robot systems to autonomously explore indoor and outdoor 3D environments. First, a basic perception map that integrates terrain and observation metrics is designed. Improved supervoxel segmentation is developed to simplify the map structure and form a high-level representation that supports lightweight communication. Second, the traversal and observation capabilities of heterogeneous robots are modeled to evaluate the requirements of task views derived from incomplete supervoxels. These task views are grouped by requirements and clustered to streamline assignment. Subsequently, the view-cluster assignment is formulated as a heterogeneous multi-depot multi-traveling salesman problem (HMDMTSP) that incorporates constraints between view-cluster requirements and robot capabilities. An improved genetic algorithm is developed to efficiently solve this problem while ensuring global consistency. Based on the assignments, redundant views within clusters are eliminated to refine exploration routes. Finally, conflicts between robots' motion paths are resolved. Simulations and field experiments in cluttered indoor and outdoor environments demonstrate that our approach effectively coordinates exploration tasks among heterogeneous robots, achieving superior exploration efficiency and communication savings compared to state-of-the-art approaches.

Xi Cheng, Weijie Shen, Haoming Chen et al.

Time series forecasting and anomaly detection are common tasks for practitioners in industries such as retail, manufacturing, advertising and energy. Two unique challenges stand out: (1) efficiently and accurately forecasting time series or detecting anomalies in large volumes automatically; and (2) ensuring interpretability of results to effectively incorporate business insights. We present ARIMA_PLUS, a novel framework to overcome these two challenges by a unique combination of (a) accurate and interpretable time series models and (b) scalable and fully managed system infrastructure. The model has a sequential and modular structure to handle different components of the time series, including holiday effects, seasonality, trend, and anomalies, which enables high interpretability of the results. Novel enhancements are made to each module, and a unified framework is established to address both forecasting and anomaly detection tasks simultaneously. In terms of accuracy, its comprehensive benchmark on the 42 public datasets in the Monash forecasting repository shows superior performance over not only well-established statistical alternatives (such as ETS, ARIMA, TBATS, Prophet) but also newer neural network models (such as DeepAR, N-BEATS, PatchTST, TimeMixer). In terms of infrastructure, it is directly built into the query engine of BigQuery in Google Cloud. It uses a simple SQL interface and automates tedious technicalities such as data cleaning and model selection. It automatically scales with managed cloud computational and storage resources, making it possible to forecast 100 million time series using only 1.5 hours with a throughput of more than 18000 time series per second. In terms of interpretability, we present several case studies to demonstrate time series insights it generates and customizability it offers.

Yuanhe Tian, Junjie Liu, Zhizhou Kou et al.

Building high-quality data resources is crucial for advancing artificial intelligence research and applications in specific domains, particularly in the Chinese medical domain. Existing Chinese medical datasets are limited in size and narrow in domain coverage, falling short of the diverse corpora required for effective pre-training. Moreover, most datasets are designed solely for LLM fine-tuning and do not support pre-training and reinforcement learning from human feedback (RLHF). In this paper, we propose a Chinese medical dataset named ChiMed 2.0, which extends our previous work ChiMed, and covers data collected from Chinese medical online platforms and generated by LLMs. ChiMed 2.0 contains 204.4M Chinese characters covering both traditional Chinese medicine classics and modern general medical data, where there are 164.8K documents for pre-training, 351.6K question-answering pairs for supervised fine-tuning (SFT), and 41.7K preference data tuples for RLHF. To validate the effectiveness of our approach for training a Chinese medical LLM, we conduct further pre-training, SFT, and RLHF experiments on representative general domain LLMs and evaluate their performance on medical benchmark datasets. The results show performance gains across different model scales, validating the dataset's effectiveness and applicability.

Jiayuan Chen, Yuxiang Li, Changyan Yi et al.

In this paper, we investigate a quality of experience (QoE)-aware resource allocation problem for reconfigurable intelligent surface (RIS)-assisted digital twin (DT) interaction with uncertain evolution. In the considered system, mobile users are expected to interact with a DT model maintained on a DT server that is deployed on a base station, via effective uplink and downlink channels assisted by an RIS. Our goal is to maximize the sum of all mobile users' joint subjective and objective QoE in DT interactions across various DT scenes, by jointly optimizing phase shift matrix, receive/transmit beamforming matrix, rendering resolution configuration and computing resource allocation. While solving this problem is challenging mainly due to the uncertain evolution of the DT model, which leads to multiple scene-specific problems, and require us to constantly re-solve each of them whenever DT model evolves. To this end, leveraging the dynamic optimization capabilities of decision transformers and the generalization strengths of generative artificial intelligence (GAI), we propose a novel GAI-aided approach, called the prompt-guided decision transformer integrated with zero-forcing optimization (PG-ZFO). Simulations are conducted to evaluate the proposed PG-ZFO, demonstrating its effectiveness and superiority over counterparts.

Bei Liu, Tieyun Qian, Bing Liu et al.

The wide spread of location-based social networks brings about a huge volume of user check-in data, which facilitates the recommendation of points of interest (POIs). Recent advances on distributed representation shed light on learning low dimensional dense vectors to alleviate the data sparsity problem. Current studies on representation learning for POI recommendation embed both users and POIs in a common latent space, and users' preference is inferred based on the distance/similarity between a user and a POI. Such an approach is not in accordance with the semantics of users and POIs as they are inherently different objects. In this paper, we present a novel spatiotemporal aware (STA) representation, which models the spatial and temporal information as \emph{a relationship connecting users and POIs}. Our model generalizes the recent advances in knowledge graph embedding. The basic idea is that the embedding of a $<$time, location$>$ pair corresponds to a translation from embeddings of users to POIs. Since the POI embedding should be close to the user embedding plus the relationship vector, the recommendation can be performed by selecting the top-\emph{k} POIs similar to the translated POI, which are all of the same type of objects. We conduct extensive experiments on two real-world datasets. The results demonstrate that our STA model achieves the state-of-the-art performance in terms of high recommendation accuracy, robustness to data sparsity and effectiveness in handling cold start problem.