H. Henry Guo

Cara Van Uden, Christian Bluethgen, Maayane Attias et al.

Interstitial lung diseases (ILD) present diagnostic challenges due to their varied manifestations and overlapping imaging features. To address this, we propose a machine learning approach that utilizes CLIP, a multimodal (image and text) self-supervised model, for ILD classification. We extensively integrate zero-shot CLIP throughout our workflow, starting from the initial extraction of image patches from volumetric CT scans and proceeding to ILD classification using "patch montages". Furthermore, we investigate how domain adaptive pretraining (DAPT) CLIP with task-specific images (CT "patch montages" extracted with ILD-specific prompts for CLIP) and/or text (lung-specific sections of radiology reports) affects downstream ILD classification performance. By leveraging CLIP-extracted "patch montages" and DAPT, we achieve strong zero-shot ILD classification results, including an AUROC of 0.893, without the need for any labeled training data. This work highlights the versatility and potential of multimodal models like CLIP for medical image classification tasks where labeled data is scarce.

Yi Jing, Zijun Yao, Hongzhu Guo et al. · tsinghua

Large language models (LLMs) demonstrate exceptional performance on tasks requiring complex linguistic abilities, such as reference disambiguation and metaphor recognition/generation. Although LLMs possess impressive capabilities, their internal mechanisms for processing and representing linguistic knowledge remain largely opaque. Prior research on linguistic mechanisms is limited by coarse granularity, limited analysis scale, and narrow focus. In this study, we propose LinguaLens, a systematic and comprehensive framework for analyzing the linguistic mechanisms of large language models, based on Sparse Auto-Encoders (SAEs). We extract a broad set of Chinese and English linguistic features across four dimensions (morphology, syntax, semantics, and pragmatics). By employing counterfactual methods, we construct a large-scale counterfactual dataset of linguistic features for mechanism analysis. Our findings reveal intrinsic representations of linguistic knowledge in LLMs, uncover patterns of cross-layer and cross-lingual distribution, and demonstrate the potential to control model outputs. This work provides a systematic suite of resources and methods for studying linguistic mechanisms, offers strong evidence that LLMs possess genuine linguistic knowledge, and lays the foundation for more interpretable and controllable language modeling in future research.