Dingyu Wang

Kang Yu, Dingyu Wang, Zimu Yuan et al.

Musculoskeletal disorders represent a leading cause of global disability, creating an urgent demand for precise interpretation of medical imaging. Current artificial intelligence (AI) approaches in orthopedics predominantly rely on task-specific, supervised learning paradigms. These methods are inherently fragmented, require extensive annotated datasets, and often lack generalizability across different modalities and clinical scenarios. The development of foundation models in this field has been constrained by the scarcity of large-scale, curated, and open-source musculoskeletal datasets. To address these challenges, we introduce OrthoFoundation, a multimodal vision foundation model optimized for musculoskeletal pathology. We constructed a pre-training dataset of 1.2 million unlabeled knee X-ray and MRI images from internal and public databases. Utilizing a Dinov3 backbone, the model was trained via self-supervised contrastive learning to capture robust radiological representations. OrthoFoundation achieves state-of-the-art (SOTA) performance across 14 downstream tasks. It attained superior accuracy in X-ray osteoarthritis diagnosis and ranked first in MRI structural injury detection. The model demonstrated remarkable label efficiency, matching supervised baselines using only 50% of labeled data. Furthermore, despite being pre-trained on knee images, OrthoFoundation exhibited exceptional cross-anatomy generalization to the hip, shoulder, and ankle. OrthoFoundation represents a significant advancement toward general-purpose AI for musculoskeletal imaging. By learning fundamental, joint-agnostic radiological semantics from large-scale multimodal data, it overcomes the limitations of conventional models, which provides a robust framework for reducing annotation burdens and enhancing diagnostic accuracy in clinical practice.

Jiachen Ye, Dingyu Wang, Shaocheng Jia et al.

Real-time estimation of vehicle locations and speeds is crucial for developing many beneficial transportation applications in traffic management and control, e.g., adaptive signal control. Recent advances in communication technologies facilitate the emergence of connected vehicles (CVs), which can share traffic information with nearby CVs or infrastructures. At the early stage of connectivity, only a portion of vehicles are CVs. The locations and speeds for those non-CVs (NCs) are not accessible and must be estimated to obtain the full traffic information. To address the above problem, this paper proposes a novel CV-based Vehicle Location and Speed estimation network, CVVLSNet, to simultaneously estimate the vehicle locations and speeds exclusively using partial CV trajectory data. A road cell occupancy (RCO) method is first proposed to represent the variable vehicle state information. Spatiotemporal interactions can be integrated by simply fusing the RCO representations. Then, CVVLSNet, taking the Coding-RAte TransformEr (CRATE) network as a backbone, is introduced to estimate the vehicle locations and speeds. Moreover, physical vehicle size constraints are also considered in loss functions. Extensive experiments indicate that the proposed method significantly outperformed the existing method under various CV penetration rates, signal timings, and volume-to-capacity ratios.

Tian Lan, Lei Xu, Zimu Yuan et al.

Musculoskeletal disorders represent a significant global health burden and are a leading cause of disability worldwide. While MRI is essential for accurate diagnosis, its interpretation remains exceptionally challenging. Radiologists must identify multiple potential abnormalities within complex anatomical structures across different imaging planes, a process that requires significant expertise and is prone to variability. We developed OrthoDiffusion, a unified diffusion-based foundation model designed for multi-task musculoskeletal MRI interpretation. The framework utilizes three orientation-specific 3D diffusion models, pre-trained in a self-supervised manner on 15,948 unlabeled knee MRI scans, to learn robust anatomical features from sagittal, coronal, and axial views. These view-specific representations are integrated to support diverse clinical tasks, including anatomical segmentation and multi-label diagnosis. Our evaluation demonstrates that OrthoDiffusion achieves excellent performance in the segmentation of 11 knee structures and the detection of 8 knee abnormalities. The model exhibited remarkable robustness across different clinical centers and MRI field strengths, consistently outperforming traditional supervised models. Notably, in settings where labeled data was scarce, OrthoDiffusion maintained high diagnostic precision using only 10\% of training labels. Furthermore, the anatomical representations learned from knee imaging proved highly transferable to other joints, achieving strong diagnostic performance across 11 diseases of the ankle and shoulder. These findings suggest that diffusion-based foundation models can serve as a unified platform for multi-disease diagnosis and anatomical segmentation, potentially improving the efficiency and accuracy of musculoskeletal MRI interpretation in real-world clinical workflows.

Dingyu Wang, Zimu Yuan, Jiajun Liu et al.

Background: The rapid integration of foundation models into clinical practice and public health necessitates a rigorous evaluation of their true clinical reasoning capabilities beyond narrow examination success. Current benchmarks, typically based on medical licensing exams or curated vignettes, fail to capture the integrated, multimodal reasoning essential for real-world patient care. Methods: We developed the Bones and Joints (B&J) Benchmark, a comprehensive evaluation framework comprising 1,245 questions derived from real-world patient cases in orthopedics and sports medicine. This benchmark assesses models across 7 tasks that mirror the clinical reasoning pathway, including knowledge recall, text and image interpretation, diagnosis generation, treatment planning, and rationale provision. We evaluated eleven vision-language models (VLMs) and six large language models (LLMs), comparing their performance against expert-derived ground truth. Results: Our results demonstrate a pronounced performance gap between task types. While state-of-the-art models achieved high accuracy, exceeding 90%, on structured multiple-choice questions, their performance markedly declined on open-ended tasks requiring multimodal integration, with accuracy scarcely reaching 60%. VLMs demonstrated substantial limitations in interpreting medical images and frequently exhibited severe text-driven hallucinations, often ignoring contradictory visual evidence. Notably, models specifically fine-tuned for medical applications showed no consistent advantage over general-purpose counterparts. Conclusions: Current artificial intelligence models are not yet clinically competent for complex, multimodal reasoning. Their safe deployment should currently be limited to supportive, text-based roles. Future advancement in core clinical tasks awaits fundamental breakthroughs in multimodal integration and visual understanding.

Seth Pettie, Dingyu Wang

In the $d$-dimensional turnstile streaming model, a frequency vector $\mathbf{x}=(\mathbf{x}(1),\ldots,\mathbf{x}(n))\in (\mathbb{R}^d)^n$ is updated entry-wisely over a stream. We consider the problem of $f$-moment estimation, where one wants to estimate $$f(\mathbf{x})=\sum_{v\in[n]}f(\mathbf{x}(v))$$ with a small-space sketch. In this work we present a simple and generic scheme to construct sketches with the novel idea of hashing indices to Lévy processes, from which one can estimate the $f$-moment $f(\mathbf{x})$ where $f$ is the characteristic exponent of the Lévy process. The fundamental Lévy-Khintchine representation theorem completely characterizes the space of all possible characteristic exponents, which in turn characterizes the set of $f$-moments that can be estimated by this generic scheme. The new scheme has strong explanatory power. It unifies the construction of many existing sketches and it implies the tractability of many nearly periodic functions that were previously unclassified. Furthermore, the scheme can be conveniently generalized to multidimensional cases ($d\geq 2$) by considering multidimensional Lévy processes and can be further generalized to estimate heterogeneous moments by projecting different indices with different Lévy processes. We conjecture that the set of tractable functions can be characterized using the Lévy-Khintchine representation theorem via what we called the Fourier-Hahn-Lévy method.

Duanrui Yu, Jing You, Xin Pei et al.

Collaborative perception allows real-time inter-agent information exchange and thus offers invaluable opportunities to enhance the perception capabilities of individual agents. However, limited communication bandwidth in practical scenarios restricts the inter-agent data transmission volume, consequently resulting in performance declines in collaborative perception systems. This implies a trade-off between perception performance and communication cost. To address this issue, we propose Which2comm, a novel multi-agent 3D object detection framework leveraging object-level sparse features. By integrating semantic information of objects into 3D object detection boxes, we introduce semantic detection boxes (SemDBs). Innovatively transmitting these information-rich object-level sparse features among agents not only significantly reduces the demanding communication volume, but also improves 3D object detection performance. Specifically, a fully sparse network is constructed to extract SemDBs from individual agents; a temporal fusion approach with a relative temporal encoding mechanism is utilized to obtain the comprehensive spatiotemporal features. Extensive experiments on the V2XSet and OPV2V datasets demonstrate that Which2comm consistently outperforms other state-of-the-art methods on both perception performance and communication cost, exhibiting better robustness to real-world latency. These results present that for multi-agent collaborative 3D object detection, transmitting only object-level sparse features is sufficient to achieve high-precision and robust performance.