Jyothi Rikhab Chand

Jyothi Rikhab Chand, Mathews Jacob

Solving inverse problems in imaging requires models that support efficient inference, uncertainty quantification, and principled probabilistic reasoning. Energy-Based Models (EBMs), with their interpretable energy landscapes and compositional structure, are well-suited for this task but have historically suffered from high computational costs and training instability. To overcome the historical shortcomings of EBMs, we introduce a fast distillation strategy to transfer the strengths of pre-trained diffusion models into multi-scale EBMs. These distilled EBMs enable efficient sampling and preserve the interpretability and compositionality inherent to potential-based frameworks. Leveraging EBM compositionality, we propose Annealed Langevin Posterior Sampling (ALPS) algorithm for Maximum-A-Posteriori (MAP), Minimum Mean Square Error (MMSE), and uncertainty estimates for inverse problems in imaging. Unlike diffusion models that use complex guidance strategies for latent variables, we perform annealing on static posterior distributions that are well-defined and composable. Experiments on image inpainting and MRI reconstruction demonstrate that our method matches or surpasses diffusion-based baselines in both accuracy and efficiency, while also supporting MAP recovery. Overall, our framework offers a scalable and principled solution for inverse problems in imaging, with potential for practical deployment in scientific and clinical settings. ALPS code is available at the GitHub repository \href{https://github.com/JyoChand/ALPS}{ALPS}.

Jyothi Rikhab Chand, Mathews Jacob

End-to-End (E2E) unrolled optimization frameworks show promise for Magnetic Resonance (MR) image recovery, but suffer from high memory usage during training. In addition, these deterministic approaches do not offer opportunities for sampling from the posterior distribution. In this paper, we introduce a memory-efficient approach for E2E learning of the posterior distribution. We represent this distribution as the combination of a data-consistency-induced likelihood term and an energy model for the prior, parameterized by a Convolutional Neural Network (CNN). The CNN weights are learned from training data in an E2E fashion using maximum likelihood optimization. The learned model enables the recovery of images from undersampled measurements using the Maximum A Posteriori (MAP) optimization. In addition, the posterior model can be sampled to derive uncertainty maps about the reconstruction. Experiments on parallel MR image reconstruction show that our approach performs comparable to the memory-intensive E2E unrolled algorithm, performs better than its memory-efficient counterpart, and can provide uncertainty maps. Our framework paves the way towards MR image reconstruction in 3D and higher dimensions

Jyothi Rikhab Chand, Mathews Jacob

Current end-to-end (E2E) and plug-and-play (PnP) image reconstruction algorithms approximate the maximum a posteriori (MAP) estimate but cannot offer sampling from the posterior distribution, like diffusion models. By contrast, it is challenging for diffusion models to be trained in an E2E fashion. This paper introduces a Deep End-to-End Posterior ENergy (DEEPEN) framework, which enables MAP estimation as well as sampling. We learn the parameters of the posterior, which is the sum of the data consistency error and the negative log-prior distribution, using maximum likelihood optimization in an E2E fashion. The proposed approach does not require algorithm unrolling, and hence has a smaller computational and memory footprint than current E2E methods, while it does not require contraction constraints typically needed by current PnP methods. Our results demonstrate that DEEPEN offers improved performance than current E2E and PnP models in the MAP setting, while it also offers faster sampling compared to diffusion models. In addition, the learned energy-based model is observed to be more robust to changes in image acquisition settings.

Jyothi Rikhab Chand, Mathews Jacob

We propose a multi-scale deep energy model that is strongly convex in the local neighbourhood around the data manifold to represent its probability density, with application in inverse problems. In particular, we represent the negative log-prior as a multi-scale energy model parameterized by a Convolutional Neural Network (CNN). We restrict the gradient of the CNN to be locally monotone, which constrains the model as a Locally Convex Multi-Scale Energy (LC-MuSE). We use the learned energy model in image-based inverse problems, where the formulation offers several desirable properties: i) uniqueness of the solution, ii) convergence guarantees to a minimum of the inverse problem, and iii) robustness to input perturbations. In the context of parallel Magnetic Resonance (MR) image reconstruction, we show that the proposed method performs better than the state-of-the-art convex regularizers, while the performance is comparable to plug-and-play regularizers and end-to-end trained methods.

Reza Ghorbani, Jyothi Rikhab Chand, Chu-Yu Lee et al.

Three-dimensional (3D) multi-slab acquisition is a technique frequently employed in high-resolution diffusion-weighted MRI in order to achieve the best signal-to-noise ratio (SNR) efficiency. However, this technique is limited by slab boundary artifacts that cause intensity fluctuations and aliasing between slabs which reduces the accuracy of anatomical imaging. Addressing this issue is crucial for advancing diffusion MRI quality and making high-resolution imaging more feasible for clinical and research applications. In this work, we propose a regularized slab profile encoding (PEN) method within a Plug-and-Play ADMM framework, incorporating multi-scale energy (MuSE) regularization to effectively improve the slab combined reconstruction. Experimental results demonstrate that the proposed method significantly improves image quality compared to non-regularized and TV-regularized PEN approaches. The regularized PEN framework provides a more robust and efficient solution for high-resolution 3D diffusion MRI, potentially enabling clearer, more reliable anatomical imaging across various applications.