Ruiyang Zhang

Jianing Qiu, Lin Li, Jiankai Sun et al.

Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive performance in various downstream tasks. A prime example is ChatGPT, whose capability has compelled people's imagination about the far-reaching influence that large AI models can have and their potential to transform different domains of our lives. In health informatics, the advent of large AI models has brought new paradigms for the design of methodologies. The scale of multi-modal data in the biomedical and health domain has been ever-expanding especially since the community embraced the era of deep learning, which provides the ground to develop, validate, and advance large AI models for breakthroughs in health-related areas. This article presents a comprehensive review of large AI models, from background to their applications. We identify seven key sectors in which large AI models are applicable and might have substantial influence, including 1) bioinformatics; 2) medical diagnosis; 3) medical imaging; 4) medical informatics; 5) medical education; 6) public health; and 7) medical robotics. We examine their challenges, followed by a critical discussion about potential future directions and pitfalls of large AI models in transforming the field of health informatics.

Ruiyang Zhang, Hu Zhang, Hang Yu et al.

The unsupervised 3D object detection is to accurately detect objects in unstructured environments with no explicit supervisory signals. This task, given sparse LiDAR point clouds, often results in compromised performance for detecting distant or small objects due to the inherent sparsity and limited spatial resolution. In this paper, we are among the early attempts to integrate LiDAR data with 2D images for unsupervised 3D detection and introduce a new method, dubbed LiDAR-2D Self-paced Learning (LiSe). We argue that RGB images serve as a valuable complement to LiDAR data, offering precise 2D localization cues, particularly when scarce LiDAR points are available for certain objects. Considering the unique characteristics of both modalities, our framework devises a self-paced learning pipeline that incorporates adaptive sampling and weak model aggregation strategies. The adaptive sampling strategy dynamically tunes the distribution of pseudo labels during training, countering the tendency of models to overfit easily detected samples, such as nearby and large-sized objects. By doing so, it ensures a balanced learning trajectory across varying object scales and distances. The weak model aggregation component consolidates the strengths of models trained under different pseudo label distributions, culminating in a robust and powerful final model. Experimental evaluations validate the efficacy of our proposed LiSe method, manifesting significant improvements of +7.1% AP$_{BEV}$ and +3.4% AP$_{3D}$ on nuScenes, and +8.3% AP$_{BEV}$ and +7.4% AP$_{3D}$ on Lyft compared to existing techniques.

Ruiyang Zhang, Hu Zhang, Hang Yu et al.

Unsupervised 3D object detection aims to identify objects of interest from unlabeled raw data, such as LiDAR points. Recent approaches usually adopt pseudo 3D bounding boxes (3D bboxes) from clustering algorithm to initialize the model training. However, pseudo bboxes inevitably contain noise, and such inaccuracies accumulate to the final model, compromising the performance. Therefore, in an attempt to mitigate the negative impact of inaccurate pseudo bboxes, we introduce a new uncertainty-aware framework for unsupervised 3D object detection, dubbed UA3D. In particular, our method consists of two phases: uncertainty estimation and uncertainty regularization. (1) In the uncertainty estimation phase, we incorporate an extra auxiliary detection branch alongside the original primary detector. The prediction disparity between the primary and auxiliary detectors could reflect fine-grained uncertainty at the box coordinate level. (2) Based on the assessed uncertainty, we adaptively adjust the weight of every 3D bbox coordinate via uncertainty regularization, refining the training process on pseudo bboxes. For pseudo bbox coordinate with high uncertainty, we assign a relatively low loss weight. Extensive experiments verify that the proposed method is robust against the noisy pseudo bboxes, yielding substantial improvements on nuScenes and Lyft compared to existing approaches, with increases of +6.9% AP$_{BEV}$ and +2.5% AP$_{3D}$ on nuScenes, and +4.1% AP$_{BEV}$ and +2.0% AP$_{3D}$ on Lyft.

Xixi Wu, Yanchao Tan, Nan Hou et al.

Document Understanding is a foundational AI capability with broad applications, and Document Question Answering (DocQA) is a key evaluation task. Traditional methods convert the document into text for processing by Large Language Models (LLMs), but this process strips away critical multi-modal information like figures. While Large Vision-Language Models (LVLMs) address this limitation, their constrained input size makes multi-page document comprehension infeasible. Retrieval-augmented generation (RAG) methods mitigate this by selecting relevant pages, but they rely solely on semantic relevance, ignoring logical connections between pages and the query, which is essential for reasoning. To this end, we propose MoLoRAG, a logic-aware retrieval framework for multi-modal, multi-page document understanding. By constructing a page graph that captures contextual relationships between pages, a lightweight VLM performs graph traversal to retrieve relevant pages, including those with logical connections often overlooked. This approach combines semantic and logical relevance to deliver more accurate retrieval. After retrieval, the top-$K$ pages are fed into arbitrary LVLMs for question answering. To enhance flexibility, MoLoRAG offers two variants: a training-free solution for easy deployment and a fine-tuned version to improve logical relevance checking. Experiments on four DocQA datasets demonstrate average improvements of 9.68% in accuracy over LVLM direct inference and 7.44% in retrieval precision over baselines. Codes and datasets are released at https://github.com/WxxShirley/MoLoRAG.

Xixi Wu, Qianguo Sun, Ruiyang Zhang et al.

Reinforcement Learning (RL) is essential for evolving Large Language Models (LLMs) into autonomous agents capable of long-horizon planning, yet a practical recipe for scaling RL in complex, multi-turn environments remains elusive. This paper presents a systematic empirical study using TravelPlanner, a challenging testbed requiring tool orchestration to satisfy multifaceted constraints. We decompose the agentic RL design space along 5 axes: reward shaping, model scaling, data composition, algorithm selection, and environmental stability. Our controlled experiments yield 7 key takeaways, e.g., (1) reward and algorithm choices are scale-dependent as smaller models benefit from staged rewards and enhanced exploration, whereas larger models converge efficiently with simpler dense rewards, (2) ~ 1K training samples with a balanced difficulty mixture mark a sweet spot for both in-domain and out-of-domain performance, and (3) environmental stability is critical to prevent policy degradation. Based on our distilled recipe, our RL-trained models achieve state-of-the-art performance on TravelPlanner, significantly outperforming leading LLMs.

Ruiyang Zhang, Qianguo Sun, Chao Song et al.

Large models are increasingly becoming autonomous agents that interact with real-world environments and use external tools to augment their static capabilities. However, most recent progress has focused on text-only large language models, which are limited to a single modality and therefore have narrower application scenarios. On the other hand, multimodal large models, while offering stronger perceptual capabilities, remain limited to static knowledge and lack the ability to access and leverage up-to-date web information. In this paper, we propose VSearcher, turning static multimodal model into multimodal search agent capable of long-horizon, multi-turn tool use in real-world web environments, including text search, image search, and web browsing, via reinforcement learning. Specifically, we introduce Iterative Injection Data Synthesis pipeline to generate large-scale, complex multimodal QA questions, which are further filtered with comprehensive metrics to ensure high quality and sufficient difficulty. We then adopt an SFT-then-RL training pipeline to turn base multimodal models to agent capable of multi-turn tool calling in real-world web environments. Besides, we propose a multimodal search benchmark MM-SearchExam dedicated to evaluating search capabilities of multimodal search agents, which proves highly challenging for recent proprietary models. Extensive evaluations across multiple multimodal search benchmarks reveal effectiveness of our method. VSearcher achieves superior performance compared to recent multimodal search agents and even surpasses several proprietary models on multimodal web search tasks.

Ruiyang Zhang, Hu Zhang, Zhedong Zheng

Given the higher information load processed by large vision-language models (LVLMs) compared to single-modal LLMs, detecting LVLM hallucinations requires more human and time expense, and thus rise a wider safety concerns. In this paper, we introduce VL-Uncertainty, the first uncertainty-based framework for detecting hallucinations in LVLMs. Different from most existing methods that require ground-truth or pseudo annotations, VL-Uncertainty utilizes uncertainty as an intrinsic metric. We measure uncertainty by analyzing the prediction variance across semantically equivalent but perturbed prompts, including visual and textual data. When LVLMs are highly confident, they provide consistent responses to semantically equivalent queries. However, when uncertain, the responses of the target LVLM become more random. Considering semantically similar answers with different wordings, we cluster LVLM responses based on their semantic content and then calculate the cluster distribution entropy as the uncertainty measure to detect hallucination. Our extensive experiments on 10 LVLMs across four benchmarks, covering both free-form and multi-choice tasks, show that VL-Uncertainty significantly outperforms strong baseline methods in hallucination detection.

Shan He, Ruiyang Zhang

Accurate prediction of seismic responses and quantification of structural damage are critical in civil engineering. Traditional approaches such as finite element analysis could lack computational efficiency, especially for complex structural systems under extreme hazards. Recently, artificial intelligence has provided an alternative to efficiently model highly nonlinear behaviors. However, existing models face challenges in generalizing across diverse structural systems. This paper proposes a novel multi-channel gated recurrent unit (MC-GRU) network aimed at achieving generalized nonlinear structural response prediction for varying structures. The key concept lies in the integration of a multi-channel input mechanism to GRU with an extra input of structural information to the candidate hidden state, which enables the network to learn the dynamic characteristics of diverse structures and thus empower the generalizability and adaptiveness to unseen structures. The performance of the proposed MC-GRU is validated through a series of case studies, including a single-degree-of-freedom linear system, a hysteretic Bouc-Wen system, and a nonlinear reinforced concrete column from experimental testing. Results indicate that the proposed MC-GRU overcomes the major generalizability issues of existing methods, with capability of accurately inferring seismic responses of varying structures. Additionally, it demonstrates enhanced capabilities in representing nonlinear structural dynamics compared to traditional models such as GRU and LSTM.

Ruiyang Zhang, Jiahao Luo, Xiaoru Feng et al.

With the rapid advancement of text-to-image (T2I) models, ensuring their safety has become increasingly critical. Existing safety approaches can be categorized into training-time and inference-time methods. While inference-time methods are widely adopted due to their cost-effectiveness, they often suffer from limitations such as over-refusal and imbalance between safety and utility. To address these challenges, we propose a multi-round safety editing framework that functions as a model-agnostic, plug-and-play module, enabling efficient safety alignment for any text-to-image model. Central to this framework is MR-SafeEdit, a multi-round image-text interleaved dataset specifically constructed for safety editing in text-to-image generation. We introduce a post-hoc safety editing paradigm that mirrors the human cognitive process of identifying and refining unsafe content. To instantiate this paradigm, we develop SafeEditor, a unified MLLM capable of multi-round safety editing on generated images. Experimental results show that SafeEditor surpasses prior safety approaches by reducing over-refusal while achieving a more favorable safety-utility balance.

Ruiyang Zhang, Hu Zhang, Hao Fei et al.

Large Multimodal Models (LMMs), harnessing the complementarity among diverse modalities, are often considered more robust than pure Language Large Models (LLMs); yet do LMMs know what they do not know? There are three key open questions remaining: (1) how to evaluate the uncertainty of diverse LMMs in a unified manner, (2) how to prompt LMMs to show its uncertainty, and (3) how to quantify uncertainty for downstream tasks. In an attempt to address these challenges, we introduce Uncertainty-o: (1) a model-agnostic framework designed to reveal uncertainty in LMMs regardless of their modalities, architectures, or capabilities, (2) an empirical exploration of multimodal prompt perturbations to uncover LMM uncertainty, offering insights and findings, and (3) derive the formulation of multimodal semantic uncertainty, which enables quantifying uncertainty from multimodal responses. Experiments across 18 benchmarks spanning various modalities and 10 LMMs (both open- and closed-source) demonstrate the effectiveness of Uncertainty-o in reliably estimating LMM uncertainty, thereby enhancing downstream tasks such as hallucination detection, hallucination mitigation, and uncertainty-aware Chain-of-Thought reasoning.