Cristiana Baloescu

Julia Wolleb, Cristiana Baloescu, Alicia Durrer et al.

Implicit neural representations (INRs) have emerged as a powerful framework for continuous image representation learning. In Functa-based approaches, each image is encoded as a latent modulation vector that conditions a shared INR, enabling strong reconstruction performance. However, the structure and interpretability of the corresponding latent spaces remain largely unexplored. In this work, we investigate the latent space of Functa-based models for ultrasound videos and propose Low-Rank-Modulated Functa (LRM-Functa), a novel architecture that enforces a low-rank adaptation of modulation vectors in the time-resolved latent space. When applied to cardiac ultrasound, the resulting latent space exhibits clearly structured periodic trajectories, facilitating visualization and interpretability of temporal patterns. The latent space can be traversed to sample novel frames, revealing smooth transitions along the cardiac cycle, and enabling direct readout of end-diastolic (ED) and end-systolic (ES) frames without additional model training. We show that LRM-Functa outperforms prior methods in unsupervised ED and ES frame detection, while compressing each video frame to as low as rank k=2 without sacrificing competitive downstream performance on ejection fraction prediction. Evaluations on out-of-distribution frame selection in a cardiac point-of-care dataset, as well as on lung ultrasound for B-line classification, demonstrate the generalizability of our approach. Overall, LRM-Functa provides a compact, interpretable, and generalizable framework for ultrasound video analysis. The code is available at https://github.com/JuliaWolleb/LRM_Functa.

Yu-Cheng Chou, Gary Y. Li, Li Chen et al.

Developing reliable healthcare AI models requires training with representative and diverse data. In imbalanced datasets, model performance tends to plateau on the more prevalent classes while remaining low on less common cases. To overcome this limitation, we propose DiffUltra, the first generative AI technique capable of synthesizing realistic Lung Ultrasound (LUS) images with extensive lesion variability. Specifically, we condition the generative AI by the introduced Lesion-anatomy Bank, which captures the lesion's structural and positional properties from real patient data to guide the image synthesis.We demonstrate that DiffUltra improves consolidation detection by 5.6% in AP compared to the models trained solely on real patient data. More importantly, DiffUltra increases data diversity and prevalence of rare cases, leading to a 25% AP improvement in detecting rare instances such as large lung consolidations, which make up only 10% of the dataset.

Gary Y. Li, Li Chen, Bryson Hicks et al.

Computer-aided pathology detection algorithms for video-based imaging modalities must accurately interpret complex spatiotemporal information by integrating findings across multiple frames. Current state-of-the-art methods operate by classifying on video sub-volumes (tubelets), but they often lose global spatial context by focusing only on local regions within detection ROIs. Here we propose a lightweight framework for tubelet-based object detection and video classification that preserves both global spatial context and fine spatiotemporal features. To address the loss of global context, we embed tubelet location, size, and confidence as inputs to the classifier. Additionally, we use ROI-aligned feature maps from a pre-trained detection model, leveraging learned feature representations to increase the receptive field and reduce computational complexity. Our method is efficient, with the spatiotemporal tubelet classifier comprising only 0.4M parameters. We apply our approach to detect and classify lung consolidation and pleural effusion in ultrasound videos. Five-fold cross-validation on 14,804 videos from 828 patients shows our method outperforms previous tubelet-based approaches and is suited for real-time workflows.