Zhen Chen

Hu Xu, Zhaolong Xing, Congcong Liu et al.

Post-training pruning compresses large language models to high sparsity using a small unlabelled calibration set, and recent work has concluded that the choice of calibration source has only modest impact on averaged post-pruning accuracy. We ask whether this conclusion survives once calibration impact is evaluated separately across distinct capability dimensions rather than aggregated. Decomposing post-pruning capability into General, Commonsense, Code, and Math, and analysing $n{=}15$ calibration sources via Spearman correlations between OIT information metrics and per-dimension retention, we uncover an opposite-sign trade-off: calibration perplexity correlates positively with General retention ($ρ{=}{+}0.71$) but negatively with Math and Code retention ($ρ{=}{-}0.53,\,{-}0.59$; $p{<}0.05$), so no single source can preserve all capabilities. We respond with multi-source calibration mixing, and propose IGSP, an information-guided self-calibration protocol that automates multi-source construction without capability-aligned corpora by minimising 4-gram aggregation and balancing perplexity across dimensions. On LLaMA-3.1-8B at SparseGPT 60% sparsity, a uniform multi-source mix reaches 58.8% total retention, outperforming the best single source (MetaMath, 50.0%) by $+8.8$ and the C4 default (40.0%) by $+18.8$; IGSP improves over Self-Cal by $+2.4$ and SGS by $+4.8$.

Jiaxing Wang, Deping Xiang, Jin Xu et al.

The capabilities of large language models (LLMs) significantly depend on training data drawn from various domains. Optimizing domain-specific mixture ratios can be modeled as a bi-level optimization problem, which we simplify into a single-level penalized form and solve with twin networks: a proxy model trained on primary data and a dynamically updated reference model trained with additional data. Our proposed method, Twin Networks for bi-level DatA mixturE optiMization (TANDEM), measures the data efficacy through the difference between the twin models and up-weights domains that benefit more from the additional data. TANDEM provides theoretical guarantees and wider applicability, compared to prior approaches. Furthermore, our bi-level perspective suggests new settings to study domain reweighting such as data-restricted scenarios and supervised fine-tuning, where optimized mixture ratios significantly improve the performance. Extensive experiments validate TANDEM's effectiveness in all scenarios.

Yi Zhang, Zhen Chen, Chih-Hong Cheng et al.

Text-to-Image (T2I) Diffusion Models (DMs) have garnered widespread attention for their impressive advancements in image generation. However, their growing popularity has raised ethical and social concerns related to key non-functional properties of trustworthiness, such as robustness, fairness, security, privacy, factuality, and explainability, similar to those in traditional deep learning (DL) tasks. Conventional approaches for studying trustworthiness in DL tasks often fall short due to the unique characteristics of T2I DMs, e.g., the multi-modal nature. Given the challenge, recent efforts have been made to develop new methods for investigating trustworthiness in T2I DMs via various means, including falsification, enhancement, verification \& validation and assessment. However, there is a notable lack of in-depth analysis concerning those non-functional properties and means. In this survey, we provide a timely and focused review of the literature on trustworthy T2I DMs, covering a concise-structured taxonomy from the perspectives of property, means, benchmarks and applications. Our review begins with an introduction to essential preliminaries of T2I DMs, and then we summarise key definitions/metrics specific to T2I tasks and analyses the means proposed in recent literature based on these definitions/metrics. Additionally, we review benchmarks and domain applications of T2I DMs. Finally, we highlight the gaps in current research, discuss the limitations of existing methods, and propose future research directions to advance the development of trustworthy T2I DMs. Furthermore, we keep up-to-date updates in this field to track the latest developments and maintain our GitHub repository at: https://github.com/wellzline/Trustworthy_T2I_DMs

Zhenye Lou, Qing Xu, Zekun Jiang et al.

Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the Segment Anything Model (SAM) has made great success in universal image segmentation by interactive prompt modes (e.g., point and box). Despite its strengths, the original SAM presents limited adaptation to medical images. Moreover, SAM requires providing manual bounding box prompts for each object to produce satisfactory segmentation masks, so it is laborious in nuclei segmentation scenarios. To address these limitations, we propose a domain-generalizable framework for nuclei image segmentation, abbreviated to NuSegDG. Specifically, we first devise a Heterogeneous Space Adapter (HS-Adapter) to learn multi-dimensional feature representations of different nuclei domains by injecting a small number of trainable parameters into the image encoder of SAM. To alleviate the labor-intensive requirement of manual prompts, we introduce a Gaussian-Kernel Prompt Encoder (GKP-Encoder) to generate density maps driven by a single point, which guides segmentation predictions by mixing position prompts and semantic prompts. Furthermore, we present a Two-Stage Mask Decoder (TSM-Decoder) to effectively convert semantic masks to instance maps without the manual demand for morphological shape refinement. Based on our experimental evaluations, the proposed NuSegDG demonstrates state-of-the-art performance in nuclei instance segmentation, exhibiting superior domain generalization capabilities. The source code is available at https://github.com/xq141839/NuSegDG.

Zhen Chen, Zongming Zhang, Wenwu Guo et al.

Surgical instrument segmentation is crucial in surgical scene understanding, thereby facilitating surgical safety. Existing algorithms directly detected all instruments of pre-defined categories in the input image, lacking the capability to segment specific instruments according to the surgeon's intention. During different stages of surgery, surgeons exhibit varying preferences and focus toward different surgical instruments. Therefore, an instrument segmentation algorithm that adheres to the surgeon's intention can minimize distractions from irrelevant instruments and assist surgeons to a great extent. The recent Segment Anything Model (SAM) reveals the capability to segment objects following prompts, but the manual annotations for prompts are impractical during the surgery. To address these limitations in operating rooms, we propose an audio-driven surgical instrument segmentation framework, named ASI-Seg, to accurately segment the required surgical instruments by parsing the audio commands of surgeons. Specifically, we propose an intention-oriented multimodal fusion to interpret the segmentation intention from audio commands and retrieve relevant instrument details to facilitate segmentation. Moreover, to guide our ASI-Seg segment of the required surgical instruments, we devise a contrastive learning prompt encoder to effectively distinguish the required instruments from the irrelevant ones. Therefore, our ASI-Seg promotes the workflow in the operating rooms, thereby providing targeted support and reducing the cognitive load on surgeons. Extensive experiments are performed to validate the ASI-Seg framework, which reveals remarkable advantages over classical state-of-the-art and medical SAMs in both semantic segmentation and intention-oriented segmentation. The source code is available at https://github.com/Zonmgin-Zhang/ASI-Seg.

Zhen Chen, Xingjian Luo, Jinlin Wu et al.

Surgical phase recognition is critical for assisting surgeons in understanding surgical videos. Existing studies focused more on online surgical phase recognition, by leveraging preceding frames to predict the current frame. Despite great progress, they formulated the task as a series of frame-wise classification, which resulted in a lack of global context of the entire procedure and incoherent predictions. Moreover, besides online analysis, accurate offline surgical phase recognition is also in significant clinical need for retrospective analysis, and existing online algorithms do not fully analyze the entire video, thereby limiting accuracy in offline analysis. To overcome these challenges and enhance both online and offline inference capabilities, we propose a universal Surgical Phase Localization Network, named SurgPLAN++, with the principle of temporal detection. To ensure a global understanding of the surgical procedure, we devise a phase localization strategy for SurgPLAN++ to predict phase segments across the entire video through phase proposals. For online analysis, to generate high-quality phase proposals, SurgPLAN++ incorporates a data augmentation strategy to extend the streaming video into a pseudo-complete video through mirroring, center-duplication, and down-sampling. For offline analysis, SurgPLAN++ capitalizes on its global phase prediction framework to continuously refine preceding predictions during each online inference step, thereby significantly improving the accuracy of phase recognition. We perform extensive experiments to validate the effectiveness, and our SurgPLAN++ achieves remarkable performance in both online and offline modes, which outperforms state-of-the-art methods. The source code is available at https://github.com/franciszchen/SurgPLAN-Plus.

Qing Xu, Jiaxuan Li, Xiangjian He et al.

The universality of deep neural networks across different modalities and their generalization capabilities to unseen domains play an essential role in medical image segmentation. The recent segment anything model (SAM) has demonstrated strong adaptability across diverse natural scenarios. However, the huge computational costs, demand for manual annotations as prompts and conflict-prone decoding process of SAM degrade its generalization capabilities in medical scenarios. To address these limitations, we propose a modality-decoupled lightweight SAM for domain-generalized medical image segmentation, named De-LightSAM. Specifically, we first devise a lightweight domain-controllable image encoder (DC-Encoder) that produces discriminative visual features for diverse modalities. Further, we introduce the self-patch prompt generator (SP-Generator) to automatically generate high-quality dense prompt embeddings for guiding segmentation decoding. Finally, we design the query-decoupled modality decoder (QM-Decoder) that leverages a one-to-one strategy to provide an independent decoding channel for every modality, preventing mutual knowledge interference of different modalities. Moreover, we design a multi-modal decoupled knowledge distillation (MDKD) strategy to leverage robust common knowledge to complement domain-specific medical feature representations. Extensive experiments indicate that De-LightSAM outperforms state-of-the-arts in diverse medical imaging segmentation tasks, displaying superior modality universality and generalization capabilities. Especially, De-LightSAM uses only 2.0% parameters compared to SAM-H. The source code is available at https://github.com/xq141839/De-LightSAM.

Qingyao Tian, Zhen Chen, Huai Liao et al.

Single-image depth estimation is essential for endoscopy tasks such as localization, reconstruction, and augmented reality. Most existing methods in surgical scenes focus on in-domain depth estimation, limiting their real-world applicability. This constraint stems from the scarcity and inferior labeling quality of medical data for training. In this work, we present EndoOmni, the first foundation model for zero-shot cross-domain depth estimation for endoscopy. To harness the potential of diverse training data, we refine the advanced self-learning paradigm that employs a teacher model to generate pseudo-labels, guiding a student model trained on large-scale labeled and unlabeled data. To address training disturbance caused by inherent noise in depth labels, we propose a robust training framework that leverages both depth labels and estimated confidence from the teacher model to jointly guide the student model training. Moreover, we propose a weighted scale-and-shift invariant loss to adaptively adjust learning weights based on label confidence, thus imposing learning bias towards cleaner label pixels while reducing the influence of highly noisy pixels. Experiments on zero-shot relative depth estimation show that our EndoOmni improves state-of-the-art methods in medical imaging for 33\% and existing foundation models for 34\% in terms of absolute relative error on specific datasets. Furthermore, our model provides strong initialization for fine-tuning metric depth estimation, maintaining superior performance in both in-domain and out-of-domain scenarios. The source code is publicly available at https://github.com/TianCuteQY/EndoOmni.

Xinyu Liu, Zhen Chen, Wuyang Li et al.

Transformers have shown remarkable performance in 3D medical image segmentation, but their high computational requirements and need for large amounts of labeled data limit their applicability. To address these challenges, we consider two crucial aspects: model efficiency and data efficiency. Specifically, we propose Light-UNETR, a lightweight transformer designed to achieve model efficiency. Light-UNETR features a Lightweight Dimension Reductive Attention (LIDR) module, which reduces spatial and channel dimensions while capturing both global and local features via multi-branch attention. Additionally, we introduce a Compact Gated Linear Unit (CGLU) to selectively control channel interaction with minimal parameters. Furthermore, we introduce a Contextual Synergic Enhancement (CSE) learning strategy, which aims to boost the data efficiency of Transformers. It first leverages the extrinsic contextual information to support the learning of unlabeled data with Attention-Guided Replacement, then applies Spatial Masking Consistency that utilizes intrinsic contextual information to enhance the spatial context reasoning for unlabeled data. Extensive experiments on various benchmarks demonstrate the superiority of our approach in both performance and efficiency. For example, with only 10% labeled data on the Left Atrial Segmentation dataset, our method surpasses BCP by 1.43% Jaccard while drastically reducing the FLOPs by 90.8% and parameters by 85.8%. Code is released at https://github.com/CUHK-AIM-Group/Light-UNETR.

Joey Chan, Zhen Chen, Ershun Pan

With the rapid proliferation of electric vehicles, the safety and reliability of lithium-ion batteries have become critical concerns. Effective anomaly detection is essential for ensuring safe battery operation. However, as battery systems and operating scenarios become increasingly complex, battery fault diagnosis and maintenance require stronger cross-domain adaptability and human-AI collaboration. Traditional fault detection and diagnosis methods are usually designed for specific scenarios and predefined workflows, making them less effective in complex real-world applications. To address the scarcity of open-source battery fault report corpora and the lack of unified maintenance knowledge representation, this study proposes a descriptive text modeling approach for battery signal reports. Monitoring signals, statistical features, anomaly records, and state assessment results are transformed into structured and readable natural language descriptions, forming a language corpus for battery health diagnosis and maintenance. Based on this corpus, we propose VBFDD-Agent, a vehicle battery fault detection and diagnosis agent for automotive-grade battery systems. VBFDD-Agent integrates descriptive battery-state texts, historical case retrieval, local maintenance manuals, and large language model reasoning to generate structured diagnostic results and maintenance recommendations. Experiments show that the proposed framework can accurately perform anomaly monitoring based on descriptive textual representations and provide flexible, efficient, and actionable maintenance suggestions. Expert evaluation further confirms the practical value of the generated recommendations. Overall, VBFDD-Agent extends traditional battery diagnosis from label prediction to interpretable and maintenance-oriented decision support.

Yan Zheng, Lemeng Wu, Xingchao Liu et al.

Deep generative models have shown success in generating 3D shapes with different representations. In this work, we propose Neural Volumetric Mesh Generator(NVMG) which can generate novel and high-quality volumetric meshes. Unlike the previous 3D generative model for point cloud, voxel, and implicit surface, the volumetric mesh representation is a ready-to-use representation in industry with details on both the surface and interior. Generating this such highly-structured data thus brings a significant challenge. We first propose a diffusion-based generative model to tackle this problem by generating voxelized shapes with close-to-reality outlines and structures. We can simply obtain a tetrahedral mesh as a template with the voxelized shape. Further, we use a voxel-conditional neural network to predict the smooth implicit surface conditioned on the voxels, and progressively project the tetrahedral mesh to the predicted surface under regularizations. The regularization terms are carefully designed so that they can (1) get rid of the defects like flipping and high distortion; (2) force the regularity of the interior and surface structure during the deformation procedure for a high-quality final mesh. As shown in the experiments, our pipeline can generate high-quality artifact-free volumetric and surface meshes from random noise or a reference image without any post-processing. Compared with the state-of-the-art voxel-to-mesh deformation method, we show more robustness and better performance when taking generated voxels as input.

Victor Churchill, Steve Manns, Zhen Chen et al.

Recent work has focused on data-driven learning of the evolution of unknown systems via deep neural networks (DNNs), with the goal of conducting long time prediction of the evolution of the unknown system. Training a DNN with low generalization error is a particularly important task in this case as error is accumulated over time. Because of the inherent randomness in DNN training, chiefly in stochastic optimization, there is uncertainty in the resulting prediction, and therefore in the generalization error. Hence, the generalization error can be viewed as a random variable with some probability distribution. Well-trained DNNs, particularly those with many hyperparameters, typically result in probability distributions for generalization error with low bias but high variance. High variance causes variability and unpredictably in the results of a trained DNN. This paper presents a computational technique which decreases the variance of the generalization error, thereby improving the reliability of the DNN model to generalize consistently. In the proposed ensemble averaging method, multiple models are independently trained and model predictions are averaged at each time step. A mathematical foundation for the method is presented, including results regarding the distribution of the local truncation error. In addition, three time-dependent differential equation problems are considered as numerical examples, demonstrating the effectiveness of the method to decrease variance of DNN predictions generally.

Adrito Das, Danyal Z. Khan, Dimitrios Psychogyios et al.

The field of computer vision applied to videos of minimally invasive surgery is ever-growing. Workflow recognition pertains to the automated recognition of various aspects of a surgery: including which surgical steps are performed; and which surgical instruments are used. This information can later be used to assist clinicians when learning the surgery; during live surgery; and when writing operation notes. The Pituitary Vision (PitVis) 2023 Challenge tasks the community to step and instrument recognition in videos of endoscopic pituitary surgery. This is a unique task when compared to other minimally invasive surgeries due to the smaller working space, which limits and distorts vision; and higher frequency of instrument and step switching, which requires more precise model predictions. Participants were provided with 25-videos, with results presented at the MICCAI-2023 conference as part of the Endoscopic Vision 2023 Challenge in Vancouver, Canada, on 08-Oct-2023. There were 18-submissions from 9-teams across 6-countries, using a variety of deep learning models. A commonality between the top performing models was incorporating spatio-temporal and multi-task methods, with greater than 50% and 10% macro-F1-score improvement over purely spacial single-task models in step and instrument recognition respectively. The PitVis-2023 Challenge therefore demonstrates state-of-the-art computer vision models in minimally invasive surgery are transferable to a new dataset, with surgery specific techniques used to enhance performance, progressing the field further. Benchmark results are provided in the paper, and the dataset is publicly available at: https://doi.org/10.5522/04/26531686.

Zhen Chen, Yibing Liu, Weihao Xie et al.

Retrieval-augmented generation (RAG) systems expose numerous design choices spanning query rewriting, chunking, retrieval depth, reranking, and context compression. In practice, these choices are often configured through heuristics, hindering systematic evaluation and reproducibility across settings. We argue that this challenge is best formulated as RAG architecture search. To support controlled and reproducible study of this problem, we introduce the RAG Intelligence Search Engine (RAISE), a comprehensive framework and benchmark for RAG hyperparameter optimization, which evaluates optimization methods for RAG pipelines under standardized search spaces and budgets. RAISE implements 13 search algorithms and evaluates them across seven public text and multimodal datasets using three random seeds. Our experiments show that optimization performance is highly task-dependent: methods that perform strongly on one dataset may not generalize consistently across others, cautioning against interpreting aggregate rankings as evidence of universally superior strategies. RAISE provides a common experimental substrate for fair, reproducible, and systematic research on RAG hyperparameter optimization.

Wenwu Guo, Jinlin Wu, Zhen Chen et al.

Vision-based surgical navigation has received increasing attention due to its non-invasive, cost-effective, and flexible advantages. In particular, a critical element of the vision-based navigation system is tracking surgical instruments. Compared with 2D instrument tracking methods, 3D instrument tracking has broader value in clinical practice, but is also more challenging due to weak texture, occlusion, and lack of Computer-Aided Design (CAD) models for 3D registration. To solve these challenges, we propose the SurgTrack, a two-stage 3D instrument tracking method for CAD-free and robust real-world applications. In the first registration stage, we incorporate an Instrument Signed Distance Field (SDF) modeling the 3D representation of instruments, achieving CAD-freed 3D registration. Due to this, we can obtain the location and orientation of instruments in the 3D space by matching the video stream with the registered SDF model. In the second tracking stage, we devise a posture graph optimization module, leveraging the historical tracking results of the posture memory pool to optimize the tracking results and improve the occlusion robustness. Furthermore, we collect the Instrument3D dataset to comprehensively evaluate the 3D tracking of surgical instruments. The extensive experiments validate the superiority and scalability of our SurgTrack, by outperforming the state-of-the-arts with a remarkable improvement. The code and dataset are available at https://github.com/wenwucode/SurgTrack.

Rongfeng Wei, Jinlin Wu, Xuexue Bai et al.

In minimally invasive surgery, surgical instrument localization is a crucial task for endoscopic videos, which enables various applications for improving surgical outcomes. However, annotating the instrument localization in endoscopic videos is tedious and labor-intensive. In contrast, obtaining the category information is easy and efficient in real-world applications. To fully utilize the category information and address the localization problem, we propose a weakly supervised localization framework named WS-YOLO for surgical instruments. By leveraging the instrument category information as the weak supervision, our WS-YOLO framework adopts an unsupervised multi-round training strategy for the localization capability training. We validate our WS-YOLO framework on the Endoscopic Vision Challenge 2023 dataset, which achieves remarkable performance in the weakly supervised surgical instrument localization. The source code is available at https://github.com/Breezewrf/WS-YOLO.

Li Pan, Yupei Zhang, Qiushi Yang et al.

Recently, multimodal deep learning, which integrates histopathology slides and molecular biomarkers, has achieved a promising performance in glioma grading. Despite great progress, due to the intra-modality complexity and inter-modality heterogeneity, existing studies suffer from inadequate histopathology representation learning and inefficient molecular-pathology knowledge alignment. These two issues hinder existing methods to precisely interpret diagnostic molecular-pathology features, thereby limiting their grading performance. Moreover, the real-world applicability of existing multimodal approaches is significantly restricted as molecular biomarkers are not always available during clinical deployment. To address these problems, we introduce a novel Focus on Focus (FoF) framework with paired pathology-genomic training and applicable pathology-only inference, enhancing molecular-pathology representation effectively. Specifically, we propose a Focus-oriented Representation Learning (FRL) module to encourage the model to identify regions positively or negatively related to glioma grading and guide it to focus on the diagnostic areas with a consistency constraint. To effectively link the molecular biomarkers to morphological features, we propose a Multi-view Cross-modal Alignment (MCA) module that projects histopathology representations into molecular subspaces, aligning morphological features with corresponding molecular biomarker status by supervised contrastive learning. Experiments on the TCGA GBM-LGG dataset demonstrate that our FoF framework significantly improves the glioma grading. Remarkably, our FoF achieves superior performance using only histopathology slides compared to existing multimodal methods. The source code is available at https://github.com/peterlipan/FoF.

Qing Xu, Kun Yuan, Yuxiang Luo et al.

Surgical segmentation is pivotal for scene understanding yet remains hindered by annotation scarcity and semantic inconsistency across diverse procedures. Existing approaches typically fine-tune natural foundation models (e.g., SAM) with limited supervision, functioning merely as domain adapters rather than surgical foundation models. Consequently, they struggle to generalize across the vast variability of surgical targets. To bridge this gap, we present LapFM, a foundation model designed to evolve robust segmentation capabilities from massive unlabeled surgical images. Distinct from medical foundation models relying on inefficient self-supervised proxy tasks, LapFM leverages a Hierarchical Concept Evolving Pre-training paradigm. First, we establish a Laparoscopic Concept Hierarchy (LCH) via a hierarchical mask decoder with parent-child query embeddings, unifying diverse entities (i.e., Anatomy, Tissue, and Instrument) into a scalable knowledge structure with cross-granularity semantic consistency. Second, we propose a Confidence-driven Evolving Labeling that iteratively generates and filters pseudo-labels based on hierarchical consistency, progressively incorporating reliable samples from unlabeled images into training. This process yields LapBench-114K, a large-scale benchmark comprising 114K image-mask pairs. Extensive experiments demonstrate that LapFM significantly outperforms state-of-the-art methods, establishing new standards for granularity-adaptive generalization in universal laparoscopic segmentation. The source code is available at https://github.com/xq141839/LapFM.

Qi Chen, Xiaohan Xing, Zhen Chen et al.

To accelerate Magnetic Resonance (MR) imaging procedures, Multi-Contrast MR Reconstruction (MCMR) has become a prevalent trend that utilizes an easily obtainable modality as an auxiliary to support high-quality reconstruction of the target modality with under-sampled k-space measurements. The exploration of global dependency and complementary information across different modalities is essential for MCMR. However, existing methods either struggle to capture global dependency due to the limited receptive field or suffer from quadratic computational complexity. To tackle this dilemma, we propose a novel Frequency and Spatial Mutual Learning Network (FSMNet), which efficiently explores global dependencies across different modalities. Specifically, the features for each modality are extracted by the Frequency-Spatial Feature Extraction (FSFE) module, featuring a frequency branch and a spatial branch. Benefiting from the global property of the Fourier transform, the frequency branch can efficiently capture global dependency with an image-size receptive field, while the spatial branch can extract local features. To exploit complementary information from the auxiliary modality, we propose a Cross-Modal Selective fusion (CMS-fusion) module that selectively incorporate the frequency and spatial features from the auxiliary modality to enhance the corresponding branch of the target modality. To further integrate the enhanced global features from the frequency branch and the enhanced local features from the spatial branch, we develop a Frequency-Spatial fusion (FS-fusion) module, resulting in a comprehensive feature representation for the target modality. Extensive experiments on the BraTS and fastMRI datasets demonstrate that the proposed FSMNet achieves state-of-the-art performance for the MCMR task with different acceleration factors. The code is available at: https://github.com/qic999/FSMNet.

Yixuan Zhang, Qing Xu, Yue Li et al.

Ultrasound image segmentation is pivotal for clinical diagnosis, yet challenged by speckle noise and imaging artifacts. Recently, DINOv3 has shown remarkable promise in medical image segmentation with its powerful representation capabilities. However, DINOv3, pre-trained on natural images, lacks sensitivity to ultrasound-specific boundary degradation. To address this limitation, we propose FreqDINO, a frequency-guided segmentation framework that enhances boundary perception and structural consistency. Specifically, we devise a Multi-scale Frequency Extraction and Alignment (MFEA) strategy to separate low-frequency structures and multi-scale high-frequency boundary details, and align them via learnable attention. We also introduce a Frequency-Guided Boundary Refinement (FGBR) module that extracts boundary prototypes from high-frequency components and refines spatial features. Furthermore, we design a Multi-task Boundary-Guided Decoder (MBGD) to ensure spatial coherence between boundary and semantic predictions. Extensive experiments demonstrate that FreqDINO surpasses state-of-the-art methods with superior achieves remarkable generalization capability. The code is at https://github.com/MingLang-FD/FreqDINO.

Cheng Feng, Congxuan Zhang, Zhen Chen et al.

Depth sensing is of paramount importance for unmanned aerial and autonomous vehicles. Nonetheless, contemporary monocular depth estimation methods employing complex deep neural networks within Convolutional Neural Networks are inadequately expedient for real-time inference on embedded platforms. This paper endeavors to surmount this challenge by proposing two efficient and lightweight architectures, RT-MonoDepth and RT-MonoDepth-S, thereby mitigating computational complexity and latency. Our methodologies not only attain accuracy comparable to prior depth estimation methods but also yield faster inference speeds. Specifically, RT-MonoDepth and RT-MonoDepth-S achieve frame rates of 18.4&30.5 FPS on NVIDIA Jetson Nano and 253.0&364.1 FPS on Jetson AGX Orin, utilizing a single RGB image of resolution 640x192. The experimental results underscore the superior accuracy and faster inference speed of our methods in comparison to existing fast monocular depth estimation methodologies on the KITTI dataset.

Yaxuan Jiao, Qing Xu, Yuxiang Luo et al.

Medical image segmentation is essential for clinical diagnosis and treatment planning. Although transformer-based methods have achieved remarkable results, their high computational cost hinders clinical deployment. To address this issue, we propose TM-UNet, a novel lightweight framework that integrates token sequence modeling with an efficient memory mechanism for efficient medical segmentation. Specifically, we introduce a multi-scale token-memory (MSTM) block that transforms 2D spatial features into token sequences through strategic spatial scanning, leveraging matrix memory cells to selectively retain and propagate discriminative contextual information across tokens. This novel token-memory mechanism acts as a dynamic knowledge store that captures long-range dependencies with linear complexity, enabling efficient global reasoning without redundant computation. Our MSTM block further incorporates exponential gating to identify token effectiveness and multi-scale contextual extraction via parallel pooling operations, enabling hierarchical representation learning without computational overhead. Extensive experiments demonstrate that TM-UNet outperforms state-of-the-art methods across diverse medical segmentation tasks with substantially reduced computation cost. The code is available at https://github.com/xq141839/TM-UNet.

Xingjian Luo, You Pang, Zhen Chen et al.

Surgical phase recognition is crucial to providing surgery understanding in smart operating rooms. Despite great progress in automatic surgical phase recognition, most existing methods are still restricted by two problems. First, these methods cannot capture discriminative visual features for each frame and motion information with simple 2D networks. Second, the frame-by-frame recognition paradigm degrades the performance due to unstable predictions within each phase, termed as phase shaking. To address these two challenges, we propose a Surgical Phase LocAlization Network, named SurgPLAN, to facilitate a more accurate and stable surgical phase recognition with the principle of temporal detection. Specifically, we first devise a Pyramid SlowFast (PSF) architecture to serve as the visual backbone to capture multi-scale spatial and temporal features by two branches with different frame sampling rates. Moreover, we propose a Temporal Phase Localization (TPL) module to generate the phase prediction based on temporal region proposals, which ensures accurate and consistent predictions within each surgical phase. Extensive experiments confirm the significant advantages of our SurgPLAN over frame-by-frame approaches in terms of both accuracy and stability.

Qingyao Tian, Zhen Chen, Huai Liao et al.

Accurate bronchoscope localization is essential for pulmonary interventions, by providing six degrees of freedom (DOF) in airway navigation. However, the robustness of current vision-based methods is often compromised in clinical practice, and they struggle to perform in real-time and to generalize across cases unseen during training. To overcome these challenges, we propose a novel Probabilistic Airway Navigation System (PANS), leveraging Monte-Carlo method with pose hypotheses and likelihoods to achieve robust and real-time bronchoscope localization. Specifically, our PANS incorporates diverse visual representations (\textit{e.g.}, odometry and landmarks) by leveraging two key modules, including the Depth-based Motion Inference (DMI) and the Bronchial Semantic Analysis (BSA). To generate the pose hypotheses of bronchoscope for PANS, we devise the DMI to accurately propagate the estimation of pose hypotheses over time. Moreover, to estimate the accurate pose likelihood, we devise the BSA module by effectively distinguishing between similar bronchial regions in endoscopic images, along with a novel metric to assess the congruence between estimated depth maps and the segmented airway structure. Under this probabilistic formulation, our PANS is capable of achieving the 6-DOF bronchoscope localization with superior accuracy and robustness. Extensive experiments on the collected pulmonary intervention dataset comprising 10 clinical cases confirm the advantage of our PANS over state-of-the-arts, in terms of both robustness and generalization in localizing deeper airway branches and the efficiency of real-time inference. The proposed PANS reveals its potential to be a reliable tool in the operating room, promising to enhance the quality and safety of pulmonary interventions.

Joey Chan, Huan Wang, Haoyu Pan et al.

Accurate forecasting of battery capacity fade is essential for the safety, reliability, and long-term efficiency of energy storage systems. However, the strong heterogeneity across cell chemistries, form factors, and operating conditions makes it difficult to build a single model that generalizes beyond its training domain. This work proposes a unified capacity forecasting framework that maintains robust performance across diverse chemistries and usage scenarios. We curate 20 public aging datasets into a large-scale corpus covering 1,704 cells and 3,961,195 charge-discharge cycle segments, spanning temperatures from $-5\,^{\circ}\mathrm{C}$ to $45\,^{\circ}\mathrm{C}$, multiple C-rates, and application-oriented profiles such as fast charging and partial cycling. On this corpus, we adopt a Time-Series Foundation Model (TSFM) backbone and apply parameter-efficient Low-Rank Adaptation (LoRA) together with physics-guided contrastive representation learning to capture shared degradation patterns. Experiments on both seen and deliberately held-out unseen datasets show that a single unified model achieves competitive or superior accuracy compared with strong per-dataset baselines, while retaining stable performance on chemistries, capacity scales, and operating conditions excluded from training. These results demonstrate the potential of TSFM-based architectures as a scalable and transferable solution for capacity degradation forecasting in real battery management systems.

Zhen Chen, Qing Xu, Xinyu Liu et al.

In digital pathology, precise nuclei segmentation is pivotal yet challenged by the diversity of tissue types, staining protocols, and imaging conditions. Recently, the segment anything model (SAM) revealed overwhelming performance in natural scenarios and impressive adaptation to medical imaging. Despite these advantages, the reliance of labor-intensive manual annotation as segmentation prompts severely hinders their clinical applicability, especially for nuclei image analysis containing massive cells where dense manual prompts are impractical. To overcome the limitations of current SAM methods while retaining the advantages, we propose the Universal prompt-free SAM framework for Nuclei segmentation (UN-SAM), by providing a fully automated solution with remarkable generalization capabilities. Specifically, to eliminate the labor-intensive requirement of per-nuclei annotations for prompt, we devise a multi-scale Self-Prompt Generation (SPGen) module to revolutionize clinical workflow by automatically generating high-quality mask hints to guide the segmentation tasks. Moreover, to unleash the generalization capability of SAM across a variety of nuclei images, we devise a Domain-adaptive Tuning Encoder (DT-Encoder) to seamlessly harmonize visual features with domain-common and domain-specific knowledge, and further devise a Domain Query-enhanced Decoder (DQ-Decoder) by leveraging learnable domain queries for segmentation decoding in different nuclei domains. Extensive experiments prove that UN-SAM with exceptional performance surpasses state-of-the-arts in nuclei instance and semantic segmentation, especially the generalization capability in zero-shot scenarios. The source code is available at https://github.com/CUHK-AIM-Group/UN-SAM.

Kun Yuan, Min Woo Sun, Zhen Chen et al.

There is a growing interest in developing strong biomedical vision-language models. A popular approach to achieve robust representations is to use web-scale scientific data. However, current biomedical vision-language pretraining typically compresses rich scientific figures and text into coarse figure-level pairs, discarding the fine-grained correspondences that clinicians actually rely on when zooming into local structures. To tackle this issue, we introduce Panel2Patch, a novel data pipeline that mines hierarchical structure from existing biomedical scientific literature, i.e., multi-panel, marker-heavy figures and their surrounding text, and converts them into multi-granular supervision. Given scientific figures and captions, Panel2Patch parses layouts, panels, and visual markers, then constructs hierarchical aligned vision-language pairs at the figure, panel, and patch levels, preserving local semantics instead of treating each figure as a single data sample. Built on this hierarchical corpus, we develop a granularity-aware pretraining strategy that unifies heterogeneous objectives from coarse didactic descriptions to fine region-focused phrases. By applying Panel2Patch to only a small set of the literature figures, we extract far more effective supervision than prior pipelines, enabling substantially better performance with less pretraining data.

Zhen Chen, Yuhao Zhai, Jun Zhang et al.

To assist surgeons in the operating theatre, surgical phase recognition is critical for developing computer-assisted surgical systems, which requires comprehensive understanding of surgical videos. Although existing studies made great progress, there are still two significant limitations worthy of improvement. First, due to the compromise of resource consumption, frame-wise visual features are extracted by 2D networks and disregard spatial and temporal knowledge of surgical actions, which hinders subsequent inter-frame modeling for phase prediction. Second, these works simply utilize ordinary classification loss with one-hot phase labels to optimize the phase predictions, and cannot fully explore surgical videos under inadequate supervision. To overcome these two limitations, we propose a Surgical Temporal Action-aware Network with sequence Regularization, named STAR-Net, to recognize surgical phases more accurately from input videos. Specifically, we propose an efficient multi-scale surgical temporal action (MS-STA) module, which integrates visual features with spatial and temporal knowledge of surgical actions at the cost of 2D networks. Moreover, we devise the dual-classifier sequence regularization (DSR) to facilitate the training of STAR-Net by the sequence guidance of an auxiliary classifier with a smaller capacity. Our STAR-Net with MS-STA and DSR can exploit visual features of surgical actions with effective regularization, thereby leading to the superior performance of surgical phase recognition. Extensive experiments on a large-scale gastrectomy surgery dataset and the public Cholec80 benchmark prove that our STAR-Net significantly outperforms state-of-the-arts of surgical phase recognition.

Jirong Yi, Qiaosheng Zhang, Zhen Chen et al.

As one of the central tasks in machine learning, regression finds lots of applications in different fields. An existing common practice for solving regression problems is the mean square error (MSE) minimization approach or its regularized variants which require prior knowledge about the models. Recently, Yi et al., proposed a mutual information based supervised learning framework where they introduced a label entropy regularization which does not require any prior knowledge. When applied to classification tasks and solved via a stochastic gradient descent (SGD) optimization algorithm, their approach achieved significant improvement over the commonly used cross entropy loss and its variants. However, they did not provide a theoretical convergence analysis of the SGD algorithm for the proposed formulation. Besides, applying the framework to regression tasks is nontrivial due to the potentially infinite support set of the label. In this paper, we investigate the regression under the mutual information based supervised learning framework. We first argue that the MSE minimization approach is equivalent to a conditional entropy learning problem, and then propose a mutual information learning formulation for solving regression problems by using a reparameterization technique. For the proposed formulation, we give the convergence analysis of the SGD algorithm for solving it in practice. Finally, we consider a multi-output regression data model where we derive the generalization performance lower bound in terms of the mutual information associated with the underlying data distribution. The result shows that the high dimensionality can be a bless instead of a curse, which is controlled by a threshold. We hope our work will serve as a good starting point for further research on the mutual information based regression.

Zhen Sun, Huan Xu, Jinlin Wu et al.

In surgical procedures, correct instrument counting is essential. Instance segmentation is a location method that locates not only an object's bounding box but also each pixel's specific details. However, obtaining mask-level annotations is labor-intensive in instance segmentation. To address this issue, we propose a novel yet effective weakly-supervised surgical instrument instance segmentation approach, named Point-based Weakly-supervised Instance Segmentation (PWISeg). PWISeg adopts an FCN-based architecture with point-to-box and point-to-mask branches to model the relationships between feature points and bounding boxes, as well as feature points and segmentation masks on FPN, accomplishing instrument detection and segmentation jointly in a single model. Since mask level annotations are hard to available in the real world, for point-to-mask training, we introduce an unsupervised projection loss, utilizing the projected relation between predicted masks and bboxes as supervision signal. On the other hand, we annotate a few pixels as the key pixel for each instrument. Based on this, we further propose a key pixel association loss and a key pixel distribution loss, driving the point-to-mask branch to generate more accurate segmentation predictions. To comprehensively evaluate this task, we unveil a novel surgical instrument dataset with manual annotations, setting up a benchmark for further research. Our comprehensive research trial validated the superior performance of our PWISeg. The results show that the accuracy of surgical instrument segmentation is improved, surpassing most methods of instance segmentation via weakly supervised bounding boxes. This improvement is consistently observed in our proposed dataset and when applied to the public HOSPI-Tools dataset.

Jirong Yi, Qiaosheng Zhang, Zhen Chen et al.

Deep learning systems have been reported to acheive state-of-the-art performances in many applications, and one of the keys for achieving this is the existence of well trained classifiers on benchmark datasets which can be used as backbone feature extractors in downstream tasks. As a main-stream loss function for training deep neural network (DNN) classifiers, the cross entropy loss can easily lead us to find models which demonstrate severe overfitting behavior when no other techniques are used for alleviating it such as data augmentation. In this paper, we prove that the existing cross entropy loss minimization for training DNN classifiers essentially learns the conditional entropy of the underlying data distribution of the dataset, i.e., the information or uncertainty remained in the labels after revealing the input. In this paper, we propose a mutual information learning framework where we train DNN classifiers via learning the mutual information between the label and input. Theoretically, we give the population error probability lower bound in terms of the mutual information. In addition, we derive the mutual information lower and upper bounds for a concrete binary classification data model in $\mbR^n$, and also the error probability lower bound in this scenario. Besides, we establish the sample complexity for accurately learning the mutual information from empirical data samples drawn from the underlying data distribution. Empirically, we conduct extensive experiments on several benchmark datasets to support our theory. Without whistles and bells, the proposed mutual information learned classifiers (MILCs) acheive far better generalization performances than the state-of-the-art classifiers with an improvement which can exceed more than 10\% in testing accuracy.

Jirong Yi, Qiaosheng Zhang, Zhen Chen et al.

Deep learning systems have been reported to achieve state-of-the-art performances in many applications, and a key is the existence of well trained classifiers on benchmark datasets. As a main-stream loss function, the cross entropy can easily lead us to find models which demonstrate severe overfitting behavior. In this paper, we show that the existing cross entropy loss minimization problem essentially learns the label conditional entropy (CE) of the underlying data distribution of the dataset. However, the CE learned in this way does not characterize well the information shared by the label and the input. In this paper, we propose a mutual information learning framework where we train deep neural network classifiers via learning the mutual information between the label and the input. Theoretically, we give the population classification error lower bound in terms of the mutual information. In addition, we derive the mutual information lower and upper bounds for a concrete binary classification data model in $\mathbb{R}^n$, and also the error probability lower bound in this scenario. Empirically, we conduct extensive experiments on several benchmark datasets to support our theory. The mutual information learned classifiers (MILCs) achieve far better generalization performances than the conditional entropy learned classifiers (CELCs) with an improvement which can exceed more than 10\% in testing accuracy.

Yiming Huang, Beilei Cui, Long Bai et al.

Simultaneous Localization and Mapping (SLAM) is essential for precise surgical interventions and robotic tasks in minimally invasive procedures. While recent advancements in 3D Gaussian Splatting (3DGS) have improved SLAM with high-quality novel view synthesis and fast rendering, these systems struggle with accurate depth and surface reconstruction due to multi-view inconsistencies. Simply incorporating SLAM and 3DGS leads to mismatches between the reconstructed frames. In this work, we present Endo-2DTAM, a real-time endoscopic SLAM system with 2D Gaussian Splatting (2DGS) to address these challenges. Endo-2DTAM incorporates a surface normal-aware pipeline, which consists of tracking, mapping, and bundle adjustment modules for geometrically accurate reconstruction. Our robust tracking module combines point-to-point and point-to-plane distance metrics, while the mapping module utilizes normal consistency and depth distortion to enhance surface reconstruction quality. We also introduce a pose-consistent strategy for efficient and geometrically coherent keyframe sampling. Extensive experiments on public endoscopic datasets demonstrate that Endo-2DTAM achieves an RMSE of $1.87\pm 0.63$ mm for depth reconstruction of surgical scenes while maintaining computationally efficient tracking, high-quality visual appearance, and real-time rendering. Our code will be released at github.com/lastbasket/Endo-2DTAM.

Jinlin Wu, Xusheng Liang, Xuexue Bai et al.

Surgical interventions, particularly in neurology, represent complex and high-stakes scenarios that impose substantial cognitive burdens on surgical teams. Although deliberate education and practice can enhance cognitive capabilities, surgical training opportunities remain limited due to patient safety concerns. To address these cognitive challenges in surgical training and operation, we propose SurgBox, an agent-driven sandbox framework to systematically enhance the cognitive capabilities of surgeons in immersive surgical simulations. Specifically, our SurgBox leverages large language models (LLMs) with tailored Retrieval-Augmented Generation (RAG) to authentically replicate various surgical roles, enabling realistic training environments for deliberate practice. In particular, we devise Surgery Copilot, an AI-driven assistant to actively coordinate the surgical information stream and support clinical decision-making, thereby diminishing the cognitive workload of surgical teams during surgery. By incorporating a novel Long-Short Memory mechanism, our Surgery Copilot can effectively balance immediate procedural assistance with comprehensive surgical knowledge. Extensive experiments using real neurosurgical procedure records validate our SurgBox framework in both enhancing surgical cognitive capabilities and supporting clinical decision-making. By providing an integrated solution for training and operational support to address cognitive challenges, our SurgBox framework advances surgical education and practice, potentially transforming surgical outcomes and healthcare quality. The code is available at https://github.com/franciszchen/SurgBox.

Hui Shan, Keyang Luo, Ming Li et al.

Recent breakthroughs in 3D generation have enabled the synthesis of high-fidelity individual assets. However, generating 3D compositional objects from single images--particularly under occlusions--remains challenging. Existing methods often degrade geometric details in hidden regions and fail to preserve the underlying object-object spatial relationships (OOR). We present a novel framework Interact3D designed to generate physically plausible interacting 3D compositional objects. Our approach first leverages advanced generative priors to curate high-quality individual assets with a unified 3D guidance scene. To physically compose these assets, we then introduce a robust two-stage composition pipeline. Based on the 3D guidance scene, the primary object is anchored through precise global-to-local geometric alignment (registration), while subsequent geometries are integrated using a differentiable Signed Distance Field (SDF)-based optimization that explicitly penalizes geometry intersections. To reduce challenging collisions, we further deploy a closed-loop, agentic refinement strategy. A Vision-Language Model (VLM) autonomously analyzes multi-view renderings of the composed scene, formulates targeted corrective prompts, and guides an image editing module to iteratively self-correct the generation pipeline. Extensive experiments demonstrate that Interact3D successfully produces promising collsion-aware compositions with improved geometric fidelity and consistent spatial relationships.

Zhen Chen, Qing Xu, Jinlin Wu et al.

Foundation models in video generation are demonstrating remarkable capabilities as potential world models for simulating the physical world. However, their application in high-stakes domains like surgery, which demand deep, specialized causal knowledge rather than general physical rules, remains a critical unexplored gap. To systematically address this challenge, we present SurgVeo, the first expert-curated benchmark for video generation model evaluation in surgery, and the Surgical Plausibility Pyramid (SPP), a novel, four-tiered framework tailored to assess model outputs from basic appearance to complex surgical strategy. On the basis of the SurgVeo benchmark, we task the advanced Veo-3 model with a zero-shot prediction task on surgical clips from laparoscopic and neurosurgical procedures. A panel of four board-certified surgeons evaluates the generated videos according to the SPP. Our results reveal a distinct "plausibility gap": while Veo-3 achieves exceptional Visual Perceptual Plausibility, it fails critically at higher levels of the SPP, including Instrument Operation Plausibility, Environment Feedback Plausibility, and Surgical Intent Plausibility. This work provides the first quantitative evidence of the chasm between visually convincing mimicry and causal understanding in surgical AI. Our findings from SurgVeo and the SPP establish a crucial foundation and roadmap for developing future models capable of navigating the complexities of specialized, real-world healthcare domains.

Shengyuan Liu, Zhen Chen, Qiushi Yang et al.

Automated diagnostic systems (ADS) have shown significant potential in the early detection of polyps during endoscopic examinations, thereby reducing the incidence of colorectal cancer. However, due to high annotation costs and strict privacy concerns, acquiring high-quality endoscopic images poses a considerable challenge in the development of ADS. Despite recent advancements in generating synthetic images for dataset expansion, existing endoscopic image generation algorithms failed to accurately generate the details of polyp boundary regions and typically required medical priors to specify plausible locations and shapes of polyps, which limited the realism and diversity of the generated images. To address these limitations, we present Polyp-Gen, the first full-automatic diffusion-based endoscopic image generation framework. Specifically, we devise a spatial-aware diffusion training scheme with a lesion-guided loss to enhance the structural context of polyp boundary regions. Moreover, to capture medical priors for the localization of potential polyp areas, we introduce a hierarchical retrieval-based sampling strategy to match similar fine-grained spatial features. In this way, our Polyp-Gen can generate realistic and diverse endoscopic images for building reliable ADS. Extensive experiments demonstrate the state-of-the-art generation quality, and the synthetic images can improve the downstream polyp detection task. Additionally, our Polyp-Gen has shown remarkable zero-shot generalizability on other datasets. The source code is available at https://github.com/CUHK-AIM-Group/Polyp-Gen.

Yang Cheng, Zhen Chen, Daming Liu

Power line detection is a critical inspection task for electricity companies and is also useful in avoiding drone obstacles. Accurately separating power lines from the surrounding area in the aerial image is still challenging due to the intricate background and low pixel ratio. In order to properly capture the guidance of the spatial edge detail prior and line features, we offer PL-UNeXt, a power line segmentation model with a booster training strategy. We design edge detail heads computing the loss in edge space to guide the lower-level detail learning and line feature heads generating auxiliary segmentation masks to supervise higher-level line feature learning. Benefited from this design, our model can reach 70.6 F1 score (+1.9%) on TTPLA and 68.41 mIoU (+5.2%) on VITL (without utilizing IR images), while preserving a real-time performance due to few inference parameters.

Qing Xu, Yuxiang Luo, Wenting Duan et al.

Medical image analysis is critical yet challenged by the need of jointly segmenting organs or tissues, and numerous instances for anatomical structures and tumor microenvironment analysis. Existing studies typically formulated different segmentation tasks in isolation, which overlooks the fundamental interdependencies between these tasks, leading to suboptimal segmentation performance and insufficient medical image understanding. To address this issue, we propose a Co-Seg++ framework for versatile medical segmentation. Specifically, we introduce a novel co-segmentation paradigm, allowing semantic and instance segmentation tasks to mutually enhance each other. We first devise a spatio-temporal prompt encoder (STP-Encoder) to capture long-range spatial and temporal relationships between segmentation regions and image embeddings as prior spatial constraints. Moreover, we devise a multi-task collaborative decoder (MTC-Decoder) that leverages cross-guidance to strengthen the contextual consistency of both tasks, jointly computing semantic and instance segmentation masks. Extensive experiments on diverse CT and histopathology datasets demonstrate that the proposed Co-Seg++ outperforms state-of-the-arts in the semantic, instance, and panoptic segmentation of dental anatomical structures, histopathology tissues, and nuclei instances. The source code is available at https://github.com/xq141839/Co-Seg-Plus.

Zhida Jiang, Zhaolong Xing, Jiawei Lu et al.

Despite algorithm-level innovations for multi-agent reinforcement learning (MARL), the underlying networked infrastructure for large-scale MARL training remains underexplored. Existing training frameworks primarily optimize for single-agent scenarios and fail to address the unique system-level challenges of MARL, including rollout-training synchronization barriers, rollout load imbalance, and training resource underutilization. To bridge this gap, we propose FlexMARL, the first end-to-end training framework that holistically optimizes rollout, training, and their orchestration for large-scale LLM-based MARL. Specifically, FlexMARL introduces the joint orchestrator to manage data flow under the rollout-training disaggregated architecture. Building upon the experience store, a novel micro-batch driven asynchronous pipeline eliminates the synchronization barriers while providing strong consistency guarantees. Rollout engine adopts a parallel sampling scheme combined with hierarchical load balancing, which adapts to skewed inter/intra-agent request patterns. Training engine achieves on-demand hardware binding through agent-centric resource allocation. The training states of different agents are swapped via unified and location-agnostic communication. Empirical results on a large-scale production cluster demonstrate that FlexMARL achieves up to 7.3x speedup and improves hardware utilization by up to 5.6x compared to existing frameworks.

Zhen Chen, Weihao Xie, Peilin Chen et al.

Retrieval-Augmented Generation (RAG) has proven effective for knowledge synthesis, yet it encounters significant challenges in practical scenarios where data is inherently discrete and fragmented. In most environments, information is distributed across isolated files like reports and logs that lack explicit links. Standard search engines process files independently, ignoring the connections between them. Furthermore, manually building Knowledge Graphs is impractical for such vast data. To bridge this gap, we present Orion-RAG. Our core insight is simple yet effective: we do not need heavy algorithms to organize this data. Instead, we use a low-complexity strategy to extract lightweight paths that naturally link related concepts. We demonstrate that this streamlined approach suffices to transform fragmented documents into semi-structured data, enabling the system to link information across different files effectively. Extensive experiments demonstrate that Orion-RAG consistently outperforms mainstream frameworks across diverse domains, supporting real-time updates and explicit Human-in-the-Loop verification with high cost-efficiency. Experiments on FinanceBench demonstrate superior precision with a 25.2% relative improvement over strong baselines.

Yong Liu, Ximan Liu, Guoqing Yang et al.

LLMs and MLLMs have become indispensable tools across a wide range of applications. E-commerce, however, poses distinctive challenges -- including intricate domain knowledge, long-tail product evidence, heterogeneous visual data, and the interplay among multiple stakeholder roles -- that diverge substantially from the general world knowledge these models are primarily trained on, often causing a notable gap between their open-domain and e-commerce performance. To systematically quantify this gap, we introduce OxyEcomBench, a unified multimodal benchmark comprising approximately 6,300 high-quality instances for real-world bilingual Chinese--English e-commerce. Although several e-commerce benchmarks have been proposed, they typically adopt a single stakeholder perspective, target a narrow set of tasks, or address isolated challenges, making it difficult to holistically assess models' understanding of the full e-commerce pipeline. OxyEcomBench addresses these limitations by jointly covering platform operators, merchants, and customers across 6 capability aspects and 29 tasks, supporting text-only and mixed-modality inputs with single-image, multi-image, single-turn, and multi-turn configurations. All data is sourced from authentic e-commerce platforms and verified by domain experts. The benchmark further adopts a difficulty-aware design with a four-level P0--P3 rubric applied to all 29 tasks whose difficulty admits stable expert consensus, and rigorously prioritizes visually salient multimodal cases in which key evidence resides in images rather than text alone. Evaluations on 20 mainstream LLMs and MLLMs show that even the leading models attain modest performance and that performance gaps narrow on OxyEcomBench, suggesting that insufficient e-commerce-specific knowledge infusion mutes the advantages of advanced general-purpose models in this domain.

Qing Xu, Yanqian Wang, Xiangjian Hea et al.

Automated lesion detection in chest X-rays has demonstrated significant potential for improving clinical diagnosis by precisely localizing pathological abnormalities. While recent promptable detection frameworks have achieved remarkable accuracy in target localization, existing methods typically rely on manual annotations as prompts, which are labor-intensive and impractical for clinical applications. To address this limitation, we propose SP-Det, a novel self-prompted detection framework that automatically generates rich textual context to guide multi-label lesion detection without requiring expert annotations. Specifically, we introduce an expert-free dual-text prompt generator (DTPG) that leverages two complementary textual modalities: semantic context prompts that capture global pathological patterns and disease beacon prompts that focus on disease-specific manifestations. Moreover, we devise a bidirectional feature enhancer (BFE) that synergistically integrates comprehensive diagnostic context with disease-specific embeddings to significantly improve feature representation and detection accuracy. Extensive experiments on two chest X-ray datasets with diverse thoracic disease categories demonstrate that our SP-Det framework outperforms state-of-the-art detection methods while completely eliminating the dependency on expert-annotated prompts compared to existing promptable architectures.

Qing Xu, Wenting Duan, Zhen Chen

Histopathology image analysis is critical yet challenged by the demand of segmenting tissue regions and nuclei instances for tumor microenvironment and cellular morphology analysis. Existing studies focused on tissue semantic segmentation or nuclei instance segmentation separately, but ignored the inherent relationship between these two tasks, resulting in insufficient histopathology understanding. To address this issue, we propose a Co-Seg framework for collaborative tissue and nuclei segmentation. Specifically, we introduce a novel co-segmentation paradigm, allowing tissue and nuclei segmentation tasks to mutually enhance each other. To this end, we first devise a region-aware prompt encoder (RP-Encoder) to provide high-quality semantic and instance region prompts as prior constraints. Moreover, we design a mutual prompt mask decoder (MP-Decoder) that leverages cross-guidance to strengthen the contextual consistency of both tasks, collaboratively computing semantic and instance segmentation masks. Extensive experiments on the PUMA dataset demonstrate that the proposed Co-Seg surpasses state-of-the-arts in the semantic, instance and panoptic segmentation of tumor tissues and nuclei instances. The source code is available at https://github.com/xq141839/Co-Seg.

Zhen Chen, Xingjian Luo, Kun Yuan et al.

Surgical video understanding is crucial for facilitating Computer-Assisted Surgery (CAS) systems. Despite significant progress in existing studies, two major limitations persist, including inadequate visual content perception and insufficient temporal awareness in surgical videos, and hinder the development of versatile CAS solutions. In this work, we propose the SurgLLM framework, an effective large multimodal model tailored for versatile surgical video understanding tasks with enhanced spatial focus and temporal awareness. Specifically, to empower the spatial focus of surgical videos, we first devise Surgical Context-aware Multimodal Pretraining (Surg-Pretrain) for the video encoder of SurgLLM, by performing instrument-centric Masked Video Reconstruction (MV-Recon) and subsequent multimodal alignment. To incorporate surgical temporal knowledge into SurgLLM, we further propose Temporal-aware Multimodal Tuning (TM-Tuning) to enhance temporal reasoning with interleaved multimodal embeddings. Moreover, to accommodate various understanding tasks of surgical videos without conflicts, we devise a Surgical Task Dynamic Ensemble to efficiently triage a query with optimal learnable parameters in our SurgLLM. Extensive experiments performed on diverse surgical video understanding tasks, including captioning, general VQA, and temporal VQA, demonstrate significant improvements over the state-of-the-art approaches, validating the effectiveness of our SurgLLM in versatile surgical video understanding. The source code is available at https://github.com/franciszchen/SurgLLM.

Tao Zhang, Jinyong Wen, Zhen Chen et al.

Pre-training techniques significantly enhance the performance of semantic segmentation tasks with limited training data. However, the efficacy under a large domain gap between pre-training (e.g. RGB) and fine-tuning (e.g. infrared) remains underexplored. In this study, we first benchmark the infrared semantic segmentation performance of various pre-training methods and reveal several phenomena distinct from the RGB domain. Next, our layerwise analysis of pre-trained attention maps uncovers that: (1) There are three typical attention patterns (local, hybrid, and global); (2) Pre-training tasks notably influence the pattern distribution across layers; (3) The hybrid pattern is crucial for semantic segmentation as it attends to both nearby and foreground elements; (4) The texture bias impedes model generalization in infrared tasks. Building on these insights, we propose UNIP, a UNified Infrared Pre-training framework, to enhance the pre-trained model performance. This framework uses the hybrid-attention distillation NMI-HAD as the pre-training target, a large-scale mixed dataset InfMix for pre-training, and a last-layer feature pyramid network LL-FPN for fine-tuning. Experimental results show that UNIP outperforms various pre-training methods by up to 13.5\% in average mIoU on three infrared segmentation tasks, evaluated using fine-tuning and linear probing metrics. UNIP-S achieves performance on par with MAE-L while requiring only 1/10 of the computational cost. Furthermore, UNIP significantly surpasses state-of-the-art (SOTA) infrared or RGB segmentation methods and demonstrates broad potential for application in other modalities, such as RGB and depth. Our code is available at https://github.com/casiatao/UNIP.

Lin Zhang, Yuteng Zhang, Dusit Niyato et al.

Generative AI (GenAI) has demonstrated remarkable capabilities in code generation, and its integration into complex product modeling and simulation code generation can significantly enhance the efficiency of the system design phase in Model-Based Systems Engineering (MBSE). In this study, we introduce a generative system design methodology framework for MBSE, offering a practical approach for the intelligent generation of simulation models for system physical properties. First, we employ inference techniques, generative models, and integrated modeling and simulation languages to construct simulation models for system physical properties based on product design documents. Subsequently, we fine-tune the language model used for simulation model generation on an existing library of simulation models and additional datasets generated through generative modeling. Finally, we introduce evaluation metrics for the generated simulation models for system physical properties. Our proposed approach to simulation model generation presents the innovative concept of scalable templates for simulation models. Using these templates, GenAI generates simulation models for system physical properties through code completion. The experimental results demonstrate that, for mainstream open-source Transformer-based models, the quality of the simulation model is significantly improved using the simulation model generation method proposed in this paper.

Li Pan, Yupei Zhang, Qiushi Yang et al.

Recently computer-aided diagnosis has demonstrated promising performance, effectively alleviating the workload of clinicians. However, the inherent sample imbalance among different diseases leads algorithms biased to the majority categories, leading to poor performance for rare categories. Existing works formulated this challenge as a long-tailed problem and attempted to tackle it by decoupling the feature representation and classification. Yet, due to the imbalanced distribution and limited samples from tail classes, these works are prone to biased representation learning and insufficient classifier calibration. To tackle these problems, we propose a new Long-tailed Medical Diagnosis (LMD) framework for balanced medical image classification on long-tailed datasets. In the initial stage, we develop a Relation-aware Representation Learning (RRL) scheme to boost the representation ability by encouraging the encoder to capture intrinsic semantic features through different data augmentations. In the subsequent stage, we propose an Iterative Classifier Calibration (ICC) scheme to calibrate the classifier iteratively. This is achieved by generating a large number of balanced virtual features and fine-tuning the encoder using an Expectation-Maximization manner. The proposed ICC compensates for minority categories to facilitate unbiased classifier optimization while maintaining the diagnostic knowledge in majority classes. Comprehensive experiments on three public long-tailed medical datasets demonstrate that our LMD framework significantly surpasses state-of-the-art approaches. The source code can be accessed at https://github.com/peterlipan/LMD.

Dongbo Xi, Zhen Chen, Yuexian Wang et al.

Feed recommendation is currently the mainstream mode for many real-world applications (e.g., TikTok, Dianping), it is usually necessary to model and predict user interests in multiple scenarios (domains) within and even outside the application. Multi-domain learning is a typical solution in this regard. While considerable efforts have been made in this regard, there are still two long-standing challenges: (1) Accurately depicting the differences among domains using domain features is crucial for enhancing the performance of each domain. However, manually designing domain features and models for numerous domains can be a laborious task. (2) Users typically have limited impressions in only a few domains. Extracting features automatically from other domains and leveraging them to improve the predictive capabilities of each domain has consistently posed a challenging problem. In this paper, we propose an Automatic Domain Feature Extraction and Personalized Integration (DFEI) framework for the large-scale multi-domain recommendation. The framework automatically transforms the behavior of each individual user into an aggregation of all user behaviors within the domain, which serves as the domain features. Unlike offline feature engineering methods, the extracted domain features are higher-order representations and directly related to the target label. Besides, by personalized integration of domain features from other domains for each user and the innovation in the training mode, the DFEI framework can yield more accurate conversion identification. Experimental results on both public and industrial datasets, consisting of over 20 domains, clearly demonstrate that the proposed framework achieves significantly better performance compared with SOTA baselines. Furthermore, we have released the source code of the proposed framework at https://github.com/xidongbo/DFEI.

Zhen Chen, Yi Zhang, Xiangyu Yin et al.

Personalized AI applications such as DreamBooth enable the generation of customized content from user images, but also raise significant privacy concerns, particularly the risk of facial identity leakage. Recent defense mechanisms like Anti-DreamBooth attempt to mitigate this risk by injecting adversarial perturbations into user photos to prevent successful personalization. However, we identify two critical yet overlooked limitations of these methods. First, the adversarial examples often exhibit perceptible artifacts such as conspicuous patterns or stripes, making them easily detectable as manipulated content. Second, the perturbations are highly fragile, as even a simple, non-learned filter can effectively remove them, thereby restoring the model's ability to memorize and reproduce user identity. To investigate this vulnerability, we propose a novel evaluation framework, AntiDB_Purify, to systematically evaluate existing defenses under realistic purification threats, including both traditional image filters and adversarial purification. Results reveal that none of the current methods maintains their protective effectiveness under such threats. These findings highlight that current defenses offer a false sense of security and underscore the urgent need for more imperceptible and robust protections to safeguard user identity in personalized generation.