Gianluca Scarpellini

Francesco Giuliari, Gianluca Scarpellini, Stuart James et al.

Positional reasoning is the process of ordering unsorted parts contained in a set into a consistent structure. We present Positional Diffusion, a plug-and-play graph formulation with Diffusion Probabilistic Models to address positional reasoning. We use the forward process to map elements' positions in a set to random positions in a continuous space. Positional Diffusion learns to reverse the noising process and recover the original positions through an Attention-based Graph Neural Network. We conduct extensive experiments with benchmark datasets including two puzzle datasets, three sentence ordering datasets, and one visual storytelling dataset, demonstrating that our method outperforms long-lasting research on puzzle solving with up to +18% compared to the second-best deep learning method, and performs on par against the state-of-the-art methods on sentence ordering and visual storytelling. Our work highlights the suitability of diffusion models for ordering problems and proposes a novel formulation and method for solving various ordering tasks. Project website at https://iit-pavis.github.io/Positional_Diffusion/

Gianluca Scarpellini, Stefano Rosa, Pietro Morerio et al.

When an object detector is deployed in a novel setting it often experiences a drop in performance. This paper studies how an embodied agent can automatically fine-tune a pre-existing object detector while exploring and acquiring images in a new environment without relying on human intervention, i.e., a fully self-supervised approach. In our setting, an agent initially learns to explore the environment using a pre-trained off-the-shelf detector to locate objects and associate pseudo-labels. By assuming that pseudo-labels for the same object must be consistent across different views, we learn the exploration policy Look Around to mine hard samples, and we devise a novel mechanism called Disagreement Reconciliation for producing refined pseudo-labels from the consensus among observations. We implement a unified benchmark of the current state-of-the-art and compare our approach with pre-existing exploration policies and perception mechanisms. Our method is shown to outperform existing approaches, improving the object detector by 6.2% in a simulated scenario, a 3.59% advancement over other state-of-the-art methods, and by 9.97% in the real robotic test without relying on ground-truth. Code for the proposed approach and baselines are available at https://iit-pavis.github.io/Look_Around_And_Learn/.

Gianluca Scarpellini, Stefano Rosa, Pietro Morerio et al.

Object detectors often experience a drop in performance when new environmental conditions are insufficiently represented in the training data. This paper studies how to automatically fine-tune a pre-existing object detector while exploring and acquiring images in a new environment without relying on human intervention, i.e., in a self-supervised fashion. In our setting, an agent initially explores the environment using a pre-trained off-the-shelf detector to locate objects and associate pseudo-labels. By assuming that pseudo-labels for the same object must be consistent across different views, we devise a novel mechanism for producing refined predictions from the consensus among observations. Our approach improves the off-the-shelf object detector by 2.66% in terms of mAP and outperforms the current state of the art without relying on ground-truth annotations.

Gianluca Scarpellini, Ksenia Konyushkova, Claudio Fantacci et al.

This paper describes $\pi2\text{vec}$, a method for representing behaviors of black box policies as feature vectors. The policy representations capture how the statistics of foundation model features change in response to the policy behavior in a task agnostic way, and can be trained from offline data, allowing them to be used in offline policy selection. This work provides a key piece of a recipe for fusing together three modern lines of research: Offline policy evaluation as a counterpart to offline RL, foundation models as generic and powerful state representations, and efficient policy selection in resource constrained environments.

Gianluca Scarpellini, Stefano Fiorini, Francesco Giuliari et al.

Reassembly tasks play a fundamental role in many fields and multiple approaches exist to solve specific reassembly problems. In this context, we posit that a general unified model can effectively address them all, irrespective of the input data type (images, 3D, etc.). We introduce DiffAssemble, a Graph Neural Network (GNN)-based architecture that learns to solve reassembly tasks using a diffusion model formulation. Our method treats the elements of a set, whether pieces of 2D patch or 3D object fragments, as nodes of a spatial graph. Training is performed by introducing noise into the position and rotation of the elements and iteratively denoising them to reconstruct the coherent initial pose. DiffAssemble achieves state-of-the-art (SOTA) results in most 2D and 3D reassembly tasks and is the first learning-based approach that solves 2D puzzles for both rotation and translation. Furthermore, we highlight its remarkable reduction in run-time, performing 11 times faster than the quickest optimization-based method for puzzle solving. Code available at https://github.com/IIT-PAVIS/DiffAssemble

Genesis Research Team, Alejandro Dobles, Nina Jovic et al. · cmu

Accurately predicting the three-dimensional structures of protein-ligand complexes remains a fundamental challenge in computational drug discovery that limits the pace and success of therapeutic design. Deep learning methods have recently shown strong potential as structural prediction tools, achieving promising accuracy across diverse biomolecular systems. However, their performance and utility are constrained by scarce experimental data, inefficient architectures, physically invalid poses, and the limited ability to exploit auxiliary information available at inference. To address these issues, we introduce Pearl (Placing Every Atom in the Right Location), a foundation model for protein-ligand cofolding at scale. Pearl addresses these challenges with three key innovations: (1) training recipes that include large-scale synthetic data to overcome data scarcity; (2) architectures that incorporate an SO(3)-equivariant diffusion module to inherently respect 3D rotational symmetries, improving generalization and sample efficiency, and (3) controllable inference, including a generalized multi-chain templating system supporting both protein and non-polymeric components as well as dual unconditional/conditional modes. Pearl establishes a new state-of-the-art performance in protein-ligand cofolding. On the key metric of generating accurate (RMSD < 2 Å) and physically valid poses, Pearl surpasses AlphaFold 3 and other open source baselines on the public Runs N' Poses and PoseBusters benchmarks, delivering 14.5% and 14.2% improvements, respectively, over the next best model. In the pocket-conditional cofolding regime, Pearl delivers $3.6\times$ improvement on a proprietary set of challenging, real-world drug targets at the more rigorous RMSD < 1 Å threshold. Finally, we demonstrate that model performance correlates directly with synthetic dataset size used in training.

Theodore Tsesmelis, Luca Palmieri, Marina Khoroshiltseva et al.

This paper proposes the RePAIR dataset that represents a challenging benchmark to test modern computational and data driven methods for puzzle-solving and reassembly tasks. Our dataset has unique properties that are uncommon to current benchmarks for 2D and 3D puzzle solving. The fragments and fractures are realistic, caused by a collapse of a fresco during a World War II bombing at the Pompeii archaeological park. The fragments are also eroded and have missing pieces with irregular shapes and different dimensions, challenging further the reassembly algorithms. The dataset is multi-modal providing high resolution images with characteristic pictorial elements, detailed 3D scans of the fragments and meta-data annotated by the archaeologists. Ground truth has been generated through several years of unceasing fieldwork, including the excavation and cleaning of each fragment, followed by manual puzzle solving by archaeologists of a subset of approx. 1000 pieces among the 16000 available. After digitizing all the fragments in 3D, a benchmark was prepared to challenge current reassembly and puzzle-solving methods that often solve more simplistic synthetic scenarios. The tested baselines show that there clearly exists a gap to fill in solving this computationally complex problem.

Jeffrey Ouyang-Zhang, Pranav Murugan, Daniel J. Diaz et al. · cmu

AlphaFold has transformed protein structure prediction, but emerging applications such as virtual ligand screening, proteome-wide folding, and de novo binder design demand predictions at a massive scale, where runtime and memory costs become prohibitive. A major bottleneck lies in the Pairformer backbone of AlphaFold3-style models, which relies on computationally expensive triangular primitives-especially triangle attention-for pairwise reasoning. We introduce Pairmixer, a streamlined alternative that eliminates triangle attention while preserving higher-order geometric reasoning capabilities that are critical for structure prediction. Pairmixer substantially improves computational efficiency, matching state-of-the-art structure predictors across folding and docking benchmarks, delivering up to 4x faster inference on long sequences while reducing training cost by 34%. Its efficiency alleviates the computational burden of downstream applications such as modeling large protein complexes, high-throughput ligand and binder screening, and hallucination-based design. Within BoltzDesign, for example, Pairmixer delivers over 2x faster sampling and scales to sequences ~30% longer than the memory limits of Pairformer.

Gianluca Scarpellini, Pietro Morerio, Alessio Del Bue

This paper presents a novel 3D human pose estimation approach using a single stream of asynchronous events as input. Most of the state-of-the-art approaches solve this task with RGB cameras, however struggling when subjects are moving fast. On the other hand, event-based 3D pose estimation benefits from the advantages of event-cameras, especially their efficiency and robustness to appearance changes. Yet, finding human poses in asynchronous events is in general more challenging than standard RGB pose estimation, since little or no events are triggered in static scenes. Here we propose the first learning-based method for 3D human pose from a single stream of events. Our method consists of two steps. First, we process the event-camera stream to predict three orthogonal heatmaps per joint; each heatmap is the projection of of the joint onto one orthogonal plane. Next, we fuse the sets of heatmaps to estimate 3D localisation of the body joints. As a further contribution, we make available a new, challenging dataset for event-based human pose estimation by simulating events from the RGB Human3.6m dataset. Experiments demonstrate that our method achieves solid accuracy, narrowing the performance gap between standard RGB and event-based vision. The code is freely available at https://iit-pavis.github.io/lifting_events_to_3d_hpe.