Yaowei Wang

Xianchao Guan, Zhiyuan Fan, Yifeng Wang et al.

The development of clinical-grade artificial intelligence in pathology is limited by the scarcity of diverse, high-quality annotated datasets. Generative models offer a potential solution but suffer from semantic instability and morphological hallucinations that compromise diagnostic reliability. To address this challenge, we introduce a Correlation-Regulated Alignment Framework for Tissue Synthesis (CRAFTS), the first generative foundation model for pathology-specific text-to-image synthesis. By leveraging a dual-stage training strategy on approximately 2.8 million image-caption pairs, CRAFTS incorporates a novel alignment mechanism that suppresses semantic drift to ensure biological accuracy. This model generates diverse pathological images spanning 30 cancer types, with quality rigorously validated by objective metrics and pathologist evaluations. Furthermore, CRAFTS-augmented datasets enhance the performance across various clinical tasks, including classification, cross-modal retrieval, self-supervised learning, and visual question answering. In addition, coupling CRAFTS with ControlNet enables precise control over tissue architecture from inputs such as nuclear segmentation masks and fluorescence images. By overcoming the critical barriers of data scarcity and privacy concerns, CRAFTS provides a limitless source of diverse, annotated histology data, effectively unlocking the creation of robust diagnostic tools for rare and complex cancer phenotypes.

Zijie Wang, Weiming Zhang, Wei Zhang et al.

Centerline graphs, crucial for path planning in autonomous driving, are traditionally learned using deterministic methods. However, these methods often lack spatial reasoning and struggle with occluded or invisible centerlines. Generative approaches, despite their potential, remain underexplored in this domain. We introduce LaneDiffusion, a novel generative paradigm for centerline graph learning. LaneDiffusion innovatively employs diffusion models to generate lane centerline priors at the Bird's Eye View (BEV) feature level, instead of directly predicting vectorized centerlines. Our method integrates a Lane Prior Injection Module (LPIM) and a Lane Prior Diffusion Module (LPDM) to effectively construct diffusion targets and manage the diffusion process. Furthermore, vectorized centerlines and topologies are then decoded from these prior-injected BEV features. Extensive evaluations on the nuScenes and Argoverse2 datasets demonstrate that LaneDiffusion significantly outperforms existing methods, achieving improvements of 4.2%, 4.6%, 4.7%, 6.4% and 1.8% on fine-grained point-level metrics (GEO F1, TOPO F1, JTOPO F1, APLS and SDA) and 2.3%, 6.4%, 6.8% and 2.1% on segment-level metrics (IoU, mAP_cf, DET_l and TOP_ll). These results establish state-of-the-art performance in centerline graph learning, offering new insights into generative models for this task.