Yuhe Gao

Runxue Bao, Yiming Sun, Yuhe Gao et al.

The application of transfer learning, leveraging knowledge from source domains to enhance model performance in a target domain, has significantly grown, supporting diverse real-world applications. Its success often relies on shared knowledge between domains, typically required in these methodologies. Commonly, methods assume identical feature and label spaces in both domains, known as homogeneous transfer learning. However, this is often impractical as source and target domains usually differ in these spaces, making precise data matching challenging and costly. Consequently, heterogeneous transfer learning (HTL), which addresses these disparities, has become a vital strategy in various tasks. In this paper, we offer an extensive review of over 60 HTL methods, covering both data-based and model-based approaches. We describe the key assumptions and algorithms of these methods and systematically categorize them into instance-based, feature representation-based, parameter regularization, and parameter tuning techniques. Additionally, we explore applications in natural language processing, computer vision, multimodal learning, and biomedicine, aiming to deepen understanding and stimulate further research in these areas. Our paper includes recent advancements in HTL, such as the introduction of transformer-based models and multimodal learning techniques, ensuring the review captures the latest developments in the field. We identify key limitations in current HTL studies and offer systematic guidance for future research, highlighting areas needing further exploration and suggesting potential directions for advancing the field.

Yuelyu Ji, Yuhe Gao, Runxue Bao et al.

The coronavirus disease 2019 (COVID-19) has led to a global pandemic of significant severity. In addition to its high level of contagiousness, COVID-19 can have a heterogeneous clinical course, ranging from asymptomatic carriers to severe and potentially life-threatening health complications. Many patients have to revisit the emergency room (ER) within a short time after discharge, which significantly increases the workload for medical staff. Early identification of such patients is crucial for helping physicians focus on treating life-threatening cases. In this study, we obtained Electronic Health Records (EHRs) of 3,210 encounters from 13 affiliated ERs within the University of Pittsburgh Medical Center between March 2020 and January 2021. We leveraged a Natural Language Processing technique, ScispaCy, to extract clinical concepts and used the 1001 most frequent concepts to develop 7-day revisit models for COVID-19 patients in ERs. The research data we collected from 13 ERs may have distributional differences that could affect the model development. To address this issue, we employed a classic deep transfer learning method called the Domain Adversarial Neural Network (DANN) and evaluated different modeling strategies, including the Multi-DANN algorithm, the Single-DANN algorithm, and three baseline methods. Results showed that the Multi-DANN models outperformed the Single-DANN models and baseline models in predicting revisits of COVID-19 patients to the ER within 7 days after discharge. Notably, the Multi-DANN strategy effectively addressed the heterogeneity among multiple source domains and improved the adaptation of source data to the target domain. Moreover, the high performance of Multi-DANN models indicates that EHRs are informative for developing a prediction model to identify COVID-19 patients who are very likely to revisit an ER within 7 days after discharge.

Yuhe Gao, Chengchun Shi, Rui Song

Dynamic treatment regimes assign personalized treatments to patients sequentially over time based on their baseline information and time-varying covariates. In mobile health applications, these covariates are typically collected at different frequencies over a long time horizon. In this paper, we propose a deep spectral Q-learning algorithm, which integrates principal component analysis (PCA) with deep Q-learning to handle the mixed frequency data. In theory, we prove that the mean return under the estimated optimal policy converges to that under the optimal one and establish its rate of convergence. The usefulness of our proposal is further illustrated via simulations and an application to a diabetes dataset.