Michael Margaliot

Michael Margaliot, Samuel Coogan

We consider contractive systems whose trajectories evolve on a compact and convex state-space. It is well-known that if the time-varying vector field of the system is periodic then the system admits a unique globally asymptotically stable periodic solution. Obtaining explicit information on this periodic solution and its dependence on various parameters is important both theoretically and in numerous applications. We develop an approach for approximating such a periodic trajectory using the periodic trajectory of a simpler system (e.g. an LTI system). Our approximation includes an error bound that is based on the input-to-state stability property of contractive systems. We show that in some cases this error bound can be computed explicitly. We also use the bound to derive a new theoretical result, namely, that a contractive system with an additive periodic input behaves like a low pass filter. We demonstrate our results using several examples from systems biology.

Ron Teichner, Ron Meir, Michael Margaliot

Given a time-series of noisy measured outputs of a dynamical system z[k], k=1...N, the Identifying Regulation with Adversarial Surrogates (IRAS) algorithm aims to find a non-trivial first integral of the system, namely, a scalar function g() such that g(z[i]) = g(z[j]), for all i,j. IRAS has been suggested recently and was used successfully in several learning tasks in models from biology and physics. Here, we give the first rigorous analysis of this algorithm in a specific setting. We assume that the observations admit a linear first integral and that they are contaminated by Gaussian noise. We show that in this case the IRAS iterations are closely related to the self-consistent-field (SCF) iterations for solving a generalized Rayleigh quotient minimization problem. Using this approach, we derive several sufficient conditions guaranteeing local convergence of IRAS to the correct first integral.