Ky Luu

Manuel Serna-Aguilera, Raegan Anderes, Page Dobbs et al.

The nicotine addiction public health crisis continues to be pervasive. In this century alone, the tobacco industry has released and marketed new products in an aggressive effort to lure new and young customers for life. Such innovations and product development, namely flavored nicotine or tobacco such as nicotine pouches, have undone years of anti-tobacco campaign work. Past work is limited both in scope and in its ability to connect large-scale data points. Thus, we introduce the Nicotine Innovation Counter-Offensive (NICO) Dataset to provide public health researchers with over 200,000 multimodal samples, including images and text descriptions, on 55 tobacco and nicotine product brands. In addition, to provide public health researchers with factual connections across a large-scale dataset, we propose NICO-RAG, a retrieval-augmented generation (RAG) framework that can retrieve image features without incurring the high-cost of language models, as well as the added cost of processing image tokens with large-scale datasets such as NICO. At construction time, NICO-RAG organizes image- and text-extracted entities and relations into hypergraphs to produce as factual responses as possible. This joint multimodal knowledge representation enables NICO-RAG to retrieve images for query answering not only by visual similarity but also by the semantic similarity of image descriptions. Experimentals show that without needing to process additional tokens from images for over 100 questions, NICO-RAG performs comparably to the state-of-the-art RAG method adapted for images.

Thanh-Dat Truong, Huu-Thien Tran, Jackson Cothren et al.

Fairness in Continual Learning for Large Multimodal Models (LMMs) is an emerging yet underexplored challenge, particularly in the presence of imbalanced data distributions that can lead to biased model updates and suboptimal performance across tasks. While recent continual learning studies have made progress in addressing catastrophic forgetting, the problem of fairness caused the imbalanced data remains largely underexplored. This paper presents a novel Fairness Direct Preference Optimization (FaiDPO or $φ$-DPO) framework for continual learning in LMMs. In particular, we first propose a new continual learning paradigm based on Direct Preference Optimization (DPO) to mitigate catastrophic forgetting by aligning learning with pairwise preference signals. Then, we identify the limitations of conventional DPO in imbalanced data and present a new $φ$-DPO loss that explicitly addresses distributional biases. We provide a comprehensive theoretical analysis demonstrating that our approach addresses both forgetting and data imbalance. Additionally, to enable $φ$-DPO-based continual learning, we construct pairwise preference annotations for existing benchmarks in the context of continual learning. Extensive experiments and ablation studies show the proposed $φ$-DPO achieves State-of-the-Art performance across multiple benchmarks, outperforming prior continual learning methods of LMMs.

Hoang-Quan Nguyen, Sankalp Pandey, Khoa Luu

Modeling long-range dependencies in sequential data remains a central challenge in machine learning. Transformers address this challenge through attention mechanisms, but their quadratic complexity with respect to sequence length limits scalability to long contexts. State-space models (SSMs) provide an efficient alternative with linear-time computation by evolving a latent state through recurrent updates, but their memory is typically formed via additive or linear transitions, which can limit their ability to capture complex global interactions across tokens. In this work, we introduce one of the first studies to leverage the superposition property of quantum systems to enhance state-based sequence modeling. In particular, we propose Quantum Long-Attention Memory (QLAM), a hybrid quantum-classical memory mechanism that can be viewed as a quantum extension of state-space models. Instead of maintaining a classical latent state updated through additive dynamics, QLAM represents the hidden state as a quantum state whose amplitudes encode a superposition of historical information. The state evolves through parameterized quantum circuits conditioned on the input, enabling a non-classical, globally update mechanism. In this way, QLAM preserves the recurrent and linear-time structure of SSMs while fundamentally enriching the memory representation through quantum superposition. Unlike attention mechanisms that explicitly compute pairwise interactions, QLAM implicitly captures global dependencies through the evolution of the quantum state, and retrieves task-relevant information via query-dependent measurements. We evaluate QLAM on sequential variants of standard image classification benchmarks, including sMNIST, sFashion-MNIST, and sCIFAR-10, where images are flattened into token sequences. Across all tasks, QLAM consistently improves over recurrent baselines and transformer-based models.

Manuel Serna-Aguilera, Vanshika Jindal, Fiona L. Goggin et al.

Understanding which genes control which traits in an organism remains one of the central challenges in biology. Despite significant advances in data collection technology, our ability to map genes to traits is still limited. This genome-to-phenome (G2P) challenge spans several problem domains, including plant breeding, and requires methods capable of reasoning over high-dimensional, heterogeneous, and biologically structured data. Current datasets and data repositories, however, are not well-equipped for this task. Current studies do not link gene expression and trait data, and most focus on very specific traits, limiting the breadth of possible correlations. To address this gap, we present the novel Gene-Graph Regression for Arabidopsis Functional Traits (GRAFT) dataset, a curated multi-modal dataset linking gene expression profiles with phenotypic trait measurements in Arabidopsis thaliana, a model organism in plant biology. GRAFT supports tasks such as phenotype prediction and interpretable graph learning. In addition, we benchmark conventional regression and explanatory baselines, including a biologically-informed hypergraph baseline, to validate gene-trait associations. To the best of our knowledge, this is the first dataset to provide multimodal gene information and heterogeneous trait or phenotype data for the same Arabidopsis thaliana specimens. With GRAFT, we aim to foster research to accurately understand the relationship between genotypes and phenotypes using gene information, higher-order gene pairings, and trait data from multiple sources.