Xuan Guo

Jingfen Zhang, Xuan Guo, Sravan Bodapati et al.

Accurate spelling correction is a critical step in modern search interfaces, especially in an era of mobile devices and speech-to-text interfaces. For services that are deployed around the world, this poses a significant challenge for multilingual NLP: spelling errors need to be caught and corrected in all languages, and even in queries that use multiple languages. In this paper, we tackle this challenge using multi-teacher distillation. On our approach, a monolingual teacher model is trained for each language/locale, and these individual models are distilled into a single multilingual student model intended to serve all languages/locales. In experiments using open-source data as well as user data from a worldwide search service, we show that this leads to highly effective spelling correction models that can meet the tight latency requirements of deployed services.

Shiva Ebrahimi, Xuan Guo

Tandem mass spectrometry (MS/MS) stands as the predominant high-throughput technique for comprehensively analyzing protein content within biological samples. This methodology is a cornerstone driving the advancement of proteomics. In recent years, substantial strides have been made in Data-Independent Acquisition (DIA) strategies, facilitating impartial and non-targeted fragmentation of precursor ions. The DIA-generated MS/MS spectra present a formidable obstacle due to their inherent high multiplexing nature. Each spectrum encapsulates fragmented product ions originating from multiple precursor peptides. This intricacy poses a particularly acute challenge in de novo peptide/protein sequencing, where current methods are ill-equipped to address the multiplexing conundrum. In this paper, we introduce DiaTrans, a deep-learning model based on transformer architecture. It deciphers peptide sequences from DIA mass spectrometry data. Our results show significant improvements over existing STOA methods, including DeepNovo-DIA and PepNet. Casanovo-DIA enhances precision by 15.14% to 34.8%, recall by 11.62% to 31.94% at the amino acid level, and boosts precision by 59% to 81.36% at the peptide level. Integrating DIA data and our DiaTrans model holds considerable promise to uncover novel peptides and more comprehensive profiling of biological samples. Casanovo-DIA is freely available under the GNU GPL license at https://github.com/Biocomputing-Research-Group/DiaTrans.

Xuan Guo, Rohit Patki, Dante Everaert et al.

The rapid introduction of new brand names into everyday language poses a unique challenge for e-commerce spelling correction services, which must distinguish genuine misspellings from novel brand names that use unconventional spelling. We seek to address this challenge via Retrieval Augmented Generation (RAG). On this approach, product names are retrieved from a catalog and incorporated into the context used by a large language model (LLM) that has been fine-tuned to do contextual spelling correction. Through quantitative evaluation and qualitative error analyses, we find improvements in spelling correction utilizing the RAG framework beyond a stand-alone LLM. We also demonstrate the value of additional finetuning of the LLM to incorporate retrieved context.

Seyedroohollah Hosseini, Xuan Guo

Mind wandering (MW) is a ubiquitous phenomenon which reflects a shift in attention from task-related to task-unrelated thoughts. There is a need for intelligent interfaces that can reorient attention when MW is detected due to its detrimental effects on performance and productivity. In this paper, we propose a deep learning model for MW detection using Electroencephalogram (EEG) signals. Specifically, we develop a channel-wise deep convolutional neural network (CNN) model to classify the features of focusing state and MW extracted from EEG signals. This is the first study that employs CNN to automatically detect MW using only EEG data. The experimental results on the collected dataset demonstrate promising performance with 91.78% accuracy, 92.84% sensitivity, and 90.73% specificity.