Rajvinder Singh

Yu Tian, Guansong Pang, Yuyuan Liu et al.

Unsupervised anomaly detection (UAD) aims to find anomalous images by optimising a detector using a training set that contains only normal images. UAD approaches can be based on reconstruction methods, self-supervised approaches, and Imagenet pre-trained models. Reconstruction methods, which detect anomalies from image reconstruction errors, are advantageous because they do not rely on the design of problem-specific pretext tasks needed by self-supervised approaches, and on the unreliable translation of models pre-trained from non-medical datasets. However, reconstruction methods may fail because they can have low reconstruction errors even for anomalous images. In this paper, we introduce a new reconstruction-based UAD approach that addresses this low-reconstruction error issue for anomalous images. Our UAD approach, the memory-augmented multi-level cross-attentional masked autoencoder (MemMC-MAE), is a transformer-based approach, consisting of a novel memory-augmented self-attention operator for the encoder and a new multi-level cross-attention operator for the decoder. MemMCMAE masks large parts of the input image during its reconstruction, reducing the risk that it will produce low reconstruction errors because anomalies are likely to be masked and cannot be reconstructed. However, when the anomaly is not masked, then the normal patterns stored in the encoder's memory combined with the decoder's multi-level cross attention will constrain the accurate reconstruction of the anomaly. We show that our method achieves SOTA anomaly detection and localisation on colonoscopy, pneumonia, and covid-19 chest x-ray datasets.

Yu Tian, Fengbei Liu, Guansong Pang et al.

Unsupervised anomaly detection (UAD) methods are trained with normal (or healthy) images only, but during testing, they are able to classify normal and abnormal (or disease) images. UAD is an important medical image analysis (MIA) method to be applied in disease screening problems because the training sets available for those problems usually contain only normal images. However, the exclusive reliance on normal images may result in the learning of ineffective low-dimensional image representations that are not sensitive enough to detect and segment unseen abnormal lesions of varying size, appearance, and shape. Pre-training UAD methods with self-supervised learning, based on computer vision techniques, can mitigate this challenge, but they are sub-optimal because they do not explore domain knowledge for designing the pretext tasks, and their contrastive learning losses do not try to cluster the normal training images, which may result in a sparse distribution of normal images that is ineffective for anomaly detection. In this paper, we propose a new self-supervised pre-training method for MIA UAD applications, named Pseudo Multi-class Strong Augmentation via Contrastive Learning (PMSACL). PMSACL consists of a novel optimisation method that contrasts a normal image class from multiple pseudo classes of synthesised abnormal images, with each class enforced to form a dense cluster in the feature space. In the experiments, we show that our PMSACL pre-training improves the accuracy of SOTA UAD methods on many MIA benchmarks using colonoscopy, fundus screening and Covid-19 Chest X-ray datasets. The code is made publicly available via https://github.com/tianyu0207/PMSACL.

Yu Tian, Guansong Pang, Fengbei Liu et al.

Unsupervised anomaly detection (UAD) learns one-class classifiers exclusively with normal (i.e., healthy) images to detect any abnormal (i.e., unhealthy) samples that do not conform to the expected normal patterns. UAD has two main advantages over its fully supervised counterpart. Firstly, it is able to directly leverage large datasets available from health screening programs that contain mostly normal image samples, avoiding the costly manual labelling of abnormal samples and the subsequent issues involved in training with extremely class-imbalanced data. Further, UAD approaches can potentially detect and localise any type of lesions that deviate from the normal patterns. One significant challenge faced by UAD methods is how to learn effective low-dimensional image representations to detect and localise subtle abnormalities, generally consisting of small lesions. To address this challenge, we propose a novel self-supervised representation learning method, called Constrained Contrastive Distribution learning for anomaly detection (CCD), which learns fine-grained feature representations by simultaneously predicting the distribution of augmented data and image contexts using contrastive learning with pretext constraints. The learned representations can be leveraged to train more anomaly-sensitive detection models. Extensive experiment results show that our method outperforms current state-of-the-art UAD approaches on three different colonoscopy and fundus screening datasets. Our code is available at https://github.com/tianyu0207/CCD.

Yu Tian, Guansong Pang, Yuanhong Chen et al.

Anomaly detection with weakly supervised video-level labels is typically formulated as a multiple instance learning (MIL) problem, in which we aim to identify snippets containing abnormal events, with each video represented as a bag of video snippets. Although current methods show effective detection performance, their recognition of the positive instances, i.e., rare abnormal snippets in the abnormal videos, is largely biased by the dominant negative instances, especially when the abnormal events are subtle anomalies that exhibit only small differences compared with normal events. This issue is exacerbated in many methods that ignore important video temporal dependencies. To address this issue, we introduce a novel and theoretically sound method, named Robust Temporal Feature Magnitude learning (RTFM), which trains a feature magnitude learning function to effectively recognise the positive instances, substantially improving the robustness of the MIL approach to the negative instances from abnormal videos. RTFM also adapts dilated convolutions and self-attention mechanisms to capture long- and short-range temporal dependencies to learn the feature magnitude more faithfully. Extensive experiments show that the RTFM-enabled MIL model (i) outperforms several state-of-the-art methods by a large margin on four benchmark data sets (ShanghaiTech, UCF-Crime, XD-Violence and UCSD-Peds) and (ii) achieves significantly improved subtle anomaly discriminability and sample efficiency. Code is available at https://github.com/tianyu0207/RTFM.

Lokesha Rasanjalee, Jin Lin Tan, Dileepa Pitawela et al.

Accurate annotation of endoscopic videos is essential yet time-consuming, particularly for challenging datasets such as dysplasia in Barrett's esophagus, where the affected regions are irregular and lack clear boundaries. Semi-automatic tools like Segment Anything Model 2 (SAM2) can ease this process by propagating annotations across frames, but small errors often accumulate and reduce accuracy, requiring expert review and correction. To address this, we systematically study how annotation errors propagate across different prompt types, namely masks, boxes, and points, and propose Learning-to-Re-Prompt (L2RP), a cost-aware framework that learns when and where to seek expert input. By tuning a human-cost parameter, our method balances annotation effort and segmentation accuracy. Experiments on a private Barrett's dysplasia dataset and the public SUN-SEG benchmark demonstrate improved temporal consistency and superior performance over baseline strategies.

Hsiang-Ting Chen, Yuan Zhang, Gustavo Carneiro et al.

While AI-assisted colonoscopy promises improved colorectal cancer screening, its success relies on effective integration into clinical practice, not just algorithmic accuracy. This paper, based on an Australian field study (observations and gastroenterologist interviews), highlights a critical disconnect: current development prioritizes machine learning model performance, overlooking essential aspects of user interface design, workflow integration, and overall user experience. Industry interactions reveal a similar emphasis on data and algorithms. To realize AI's full potential, the HCI community must champion user-centered design, ensuring these systems are usable, support endoscopist expertise, and enhance patient outcomes.

David Butler, Yuan Zhang, Tim Chen et al.

Real-time and robust automatic detection of polyps from colonoscopy videos are essential tasks to help improve the performance of doctors during this exam. The current focus of the field is on the development of accurate but inefficient detectors that will not enable a real-time application. We advocate that the field should instead focus on the development of simple and efficient detectors that an be combined with effective trackers to allow the implementation of real-time polyp detectors. In this paper, we propose a Kalman filtering tracker that can work together with powerful, but efficient detectors, enabling the implementation of real-time polyp detectors. In particular, we show that the combination of our Kalman filtering with the detector PP-YOLO shows state-of-the-art (SOTA) detection accuracy and real-time processing. More specifically, our approach has SOTA results on the CVC-ClinicDB dataset, with a recall of 0.740, precision of 0.869, $F_1$ score of 0.799, an average precision (AP) of 0.837, and can run in real time (i.e., 30 frames per second). We also evaluate our method on a subset of the Hyper-Kvasir annotated by our clinical collaborators, resulting in SOTA results, with a recall of 0.956, precision of 0.875, $F_1$ score of 0.914, AP of 0.952, and can run in real time.

Yu Tian, Leonardo Zorron Cheng Tao Pu, Yuyuan Liu et al.

In this paper, we propose and analyse a system that can automatically detect, localise and classify polyps from colonoscopy videos. The detection of frames with polyps is formulated as a few-shot anomaly classification problem, where the training set is highly imbalanced with the large majority of frames consisting of normal images and a small minority comprising frames with polyps. Colonoscopy videos may contain blurry images and frames displaying feces and water jet sprays to clean the colon -- such frames can mistakenly be detected as anomalies, so we have implemented a classifier to reject these two types of frames before polyp detection takes place. Next, given a frame containing a polyp, our method localises (with a bounding box around the polyp) and classifies it into five different classes. Furthermore, we study a method to improve the reliability and interpretability of the classification result using uncertainty estimation and classification calibration. Classification uncertainty and calibration not only help improve classification accuracy by rejecting low-confidence and high-uncertain results, but can be used by doctors to decide how to decide on the classification of a polyp. All the proposed detection, localisation and classification methods are tested using large data sets and compared with relevant baseline approaches.

Yu Tian, Gabriel Maicas, Leonardo Zorron Cheng Tao Pu et al.

Anomaly detection methods generally target the learning of a normal image distribution (i.e., inliers showing healthy cases) and during testing, samples relatively far from the learned distribution are classified as anomalies (i.e., outliers showing disease cases). These approaches tend to be sensitive to outliers that lie relatively close to inliers (e.g., a colonoscopy image with a small polyp). In this paper, we address the inappropriate sensitivity to outliers by also learning from inliers. We propose a new few-shot anomaly detection method based on an encoder trained to maximise the mutual information between feature embeddings and normal images, followed by a few-shot score inference network, trained with a large set of inliers and a substantially smaller set of outliers. We evaluate our proposed method on the clinical problem of detecting frames containing polyps from colonoscopy video sequences, where the training set has 13350 normal images (i.e., without polyps) and less than 100 abnormal images (i.e., with polyps). The results of our proposed model on this data set reveal a state-of-the-art detection result, while the performance based on different number of anomaly samples is relatively stable after approximately 40 abnormal training images.

Yuyuan Liu, Yu Tian, Gabriel Maicas et al.

The automatic detection of frames containing polyps from a colonoscopy video sequence is an important first step for a fully automated colonoscopy analysis tool. Typically, such detection system is built using a large annotated data set of frames with and without polyps, which is expensive to be obtained. In this paper, we introduce a new system that detects frames containing polyps as anomalies from a distribution of frames from exams that do not contain any polyps. The system is trained using a one-class training set consisting of colonoscopy frames without polyps -- such training set is considerably less expensive to obtain, compared to the 2-class data set mentioned above. During inference, the system is only able to reconstruct frames without polyps, and when it tries to reconstruct a frame with polyp, it automatically removes (i.e., photoshop) it from the frame -- the difference between the input and reconstructed frames is used to detect frames with polyps. We name our proposed model as anomaly detection generative adversarial network (ADGAN), comprising a dual GAN with two generators and two discriminators. We show that our proposed approach achieves the state-of-the-art result on this data set, compared with recently proposed anomaly detection systems.