Tingwei Quan

Hongtao Kang, Die Luo, Li Chen et al.

In practice, digital pathology images are often affected by various factors, resulting in very large differences in color and brightness. Stain normalization can effectively reduce the differences in color and brightness of digital pathology images, thus improving the performance of computer-aided diagnostic systems. Conventional stain normalization methods rely on one or several reference images, but one or several images may not adequately represent the entire dataset. Although learning-based stain normalization methods are a general approach, they use complex deep networks, which not only greatly reduce computational efficiency, but also risk introducing artifacts. Some studies use specialized network structures to enhance computational efficiency and reliability, but these methods are difficult to apply to multi-to-one stain normalization due to insufficient network capacity. In this study, we introduced dynamic-parameter network and proposed a novel method for stain normalization, called ParamNet. ParamNet addresses the challenges of limited network capacity and computational efficiency by introducing dynamic parameters (weights and biases of convolutional layers) into the network design. By effectively leveraging these parameters, ParamNet achieves superior performance in stain normalization while maintaining computational efficiency. Results show ParamNet can normalize one whole slide image (WSI) of 100,000x100,000 within 25s. The code is available at: https://github.com/khtao/ParamNet.

Fengchen He, Dayang Zhao, Hao Xu et al.

Many studies utilize dual-pixel (DP) sensor phase characteristics for various applications, such as depth estimation and deblurring. However, since the DP image features are entirely determined by the camera hardware, DP-depth paired datasets are very scarce, especially when performing depth estimation on customized cameras. To overcome this, studies simulate DP images using ideal optical system models. However, these simulations often violate real optical propagation laws,leading to poor generalization to real DP data. To address this, we investigate the domain gap between simulated and real DP data, and propose solutions using the Simulating DP images from ray tracing (Sdirt) scheme. The Sdirt generates realistic DP images via ray tracing and integrates them into the depth estimation training pipeline. Experimental results show that models trained with Sdirt-simulated images generalize better to real DP data.

Hongtao Kang, Die Luo, Weihua Feng et al.

Stain normalization often refers to transferring the color distribution of the source image to that of the target image and has been widely used in biomedical image analysis. The conventional stain normalization is regarded as constructing a pixel-by-pixel color mapping model, which only depends on one reference image, and can not accurately achieve the style transformation between image datasets. In principle, this style transformation can be well solved by the deep learning-based methods due to its complicated network structure, whereas, its complicated structure results in the low computational efficiency and artifacts in the style transformation, which has restricted the practical application. Here, we use distillation learning to reduce the complexity of deep learning methods and a fast and robust network called StainNet to learn the color mapping between the source image and target image. StainNet can learn the color mapping relationship from a whole dataset and adjust the color value in a pixel-to-pixel manner. The pixel-to-pixel manner restricts the network size and avoids artifacts in the style transformation. The results on the cytopathology and histopathology datasets show that StainNet can achieve comparable performance to the deep learning-based methods. Computation results demonstrate StainNet is more than 40 times faster than StainGAN and can normalize a 100,000x100,000 whole slide image in 40 seconds.