Letian Gao

Letian Gao, Zhi John Lu

RNA plays a pivotal role in diverse biological processes, ranging from gene regulation to catalysis. Recent advances in RNA design, such as RfamGen, Ribodiffusion and RDesign, have demonstrated promising results, with successful designs of functional sequences. However, RNA design remains challenging due to the inherent flexibility of RNA molecules and the scarcity of experimental data on tertiary and secondary structures compared to proteins. These limitations highlight the need for a more universal and comprehensive approach to RNA design that integrates diverse annotation information at the sequence level. To address these challenges, we propose RNACG (RNA Conditional Generator), a universal framework for RNA sequence design based on flow matching. RNACG supports diverse conditional inputs, including structural, functional, and family-specific annotations, and offers a modular design that allows users to customize the encoding network for specific tasks. By unifying sequence generation under a single framework, RNACG enables the integration of multiple RNA design paradigms, from family-specific generation to tertiary structure inverse folding.

Jiahao Chen, Letian Gao, Yanhao Zhu et al.

Recent advances in generative modeling have enabled significant progress in structure-based drug design (SBDD). Existing methods typically condition molecule generation on empty binding pockets from holo complexes, overlooking informative components such as the filler (ligands and solvent). Here, we leverage low-resolution electron density (ED) derived from the filler as a physically grounded condition for \textit{de novo} drug design. We consider two types of ED, calculated and cryo-EM/X-ray, obtainable from computational or experimental sources, supporting unified pre-training and experimental integration. Compared with rigid pocket representations, experimental ED naturally captures conformational flexibility and provides a more faithful description of the binding environment. Based on this, we introduce EDMolGPT, a decoder-only autoregressive framework that generates molecules from low-resolution ED point clouds. By grounding generation in physically meaningful density signals, EDMolGPT mitigates structural bias and produces molecules with 3D conformations. Evaluations on 101 biological targets verify the effectiveness. Our project page: https://jiahaochen1.github.io/EDMolGPT_Page/.

Hao Xiang, Zhaoliang Zheng, Xin Xia et al.

Recent advancements in Vehicle-to-Everything (V2X) technologies have enabled autonomous vehicles to share sensing information to see through occlusions, greatly boosting the perception capability. However, there are no real-world datasets to facilitate the real V2X cooperative perception research -- existing datasets either only support Vehicle-to-Infrastructure cooperation or Vehicle-to-Vehicle cooperation. In this paper, we present V2X-Real, a large-scale dataset that includes a mixture of multiple vehicles and smart infrastructure to facilitate the V2X cooperative perception development with multi-modality sensing data. Our V2X-Real is collected using two connected automated vehicles and two smart infrastructure, which are all equipped with multi-modal sensors including LiDAR sensors and multi-view cameras. The whole dataset contains 33K LiDAR frames and 171K camera data with over 1.2M annotated bounding boxes of 10 categories in very challenging urban scenarios. According to the collaboration mode and ego perspective, we derive four types of datasets for Vehicle-Centric, Infrastructure-Centric, Vehicle-to-Vehicle, and Infrastructure-to-Infrastructure cooperative perception. Comprehensive multi-class multi-agent benchmarks of SOTA cooperative perception methods are provided. The V2X-Real dataset and codebase are available at https://mobility-lab.seas.ucla.edu/v2x-real.

Hao Xiang, Zhaoliang Zheng, Xin Xia et al.

Cooperative perception enabled by Vehicle-to-Everything (V2X) communication holds significant promise for enhancing the perception capabilities of autonomous vehicles, allowing them to overcome occlusions and extend their field of view. However, existing research predominantly relies on simulated environments or static datasets, leaving the feasibility and effectiveness of V2X cooperative perception especially for intermediate fusion in real-world scenarios largely unexplored. In this work, we introduce V2X-ReaLO, an open online cooperative perception framework deployed on real vehicles and smart infrastructure that integrates early, late, and intermediate fusion methods within a unified pipeline and provides the first practical demonstration of online intermediate fusion's feasibility and performance under genuine real-world conditions. Additionally, we present an open benchmark dataset specifically designed to assess the performance of online cooperative perception systems. This new dataset extends V2X-Real dataset to dynamic, synchronized ROS bags and provides 25,028 test frames with 6,850 annotated key frames in challenging urban scenarios. By enabling real-time assessments of perception accuracy and communication lantency under dynamic conditions, V2X-ReaLO sets a new benchmark for advancing and optimizing cooperative perception systems in real-world applications. The codes and datasets will be released to further advance the field.