Nicholas Summerfield

Qisheng He, Nicholas Summerfield, Ming Dong et al.

Medical image segmentation of tumors and organs at risk is a time-consuming yet critical process in the clinic that utilizes multi-modality imaging (e.g, different acquisitions, data types, and sequences) to increase segmentation precision. In this paper, we propose a novel framework, Modality-Agnostic learning through Multi-modality Self-dist-illation (MAG-MS), to investigate the impact of input modalities on medical image segmentation. MAG-MS distills knowledge from the fusion of multiple modalities and applies it to enhance representation learning for individual modalities. Thus, it provides a versatile and efficient approach to handle limited modalities during testing. Our extensive experiments on benchmark datasets demonstrate the high efficiency of MAG-MS and its superior segmentation performance than current state-of-the-art methods. Furthermore, using MAG-MS, we provide valuable insight and guidance on selecting input modalities for medical image segmentation tasks.

Nicholas Summerfield, Qisheng He, Alex Kuo et al.

Cardiac substructure delineation is emerging in treatment planning to minimize the risk of radiation-induced heart disease. Deep learning offers efficient methods to reduce contouring burden but currently lacks generalizability across different modalities and overlapping structures. This work introduces and validates a Modality-AGnostic Image Cascade (MAGIC) deep-learning pipeline for comprehensive and multi-modal cardiac substructure segmentation. MAGIC is implemented through replicated encoding and decoding branches of an nnU-Net backbone to handle multi-modality inputs and overlapping labels. First benchmarked on the multi-modality whole-heart segmentation (MMWHS) dataset including cardiac CT-angiography (CCTA) and MR modalities, twenty cardiac substructures (heart, chambers, great vessels (GVs), valves, coronary arteries (CAs), and conduction nodes) from clinical simulation CT (Sim-CT), low-field MR-Linac, and cardiac CT-angiography (CCTA) modalities were delineated to train semi-supervised (n=151), validate (n=15), and test (n=30) MAGIC. For comparison, fourteen single-modality comparison models (two MMWHS modalities and four subgroups across three clinical modalities) were trained. Methods were evaluated for efficiency and against reference contours through the Dice similarity coefficient (DSC) and two-tailed Wilcoxon Signed-Rank test (p<0.05). Average MMWHS DSC scores across CCTA and MR inputs were 0.88(0.08) and 0.87(0.04) respectively with significant improvement over unimodal baselines. Average 20-structure DSC scores were 0.75(0.16) for Sim-CT, 0.68(0.21) for MR-Linac, and 0.80(0.16) for CCTA. Furthermore, >80% and >70% reductions in training time and parameters were achieved, respectively. MAGIC offers an efficient, lightweight solution capable of segmenting multiple image modalities and overlapping structures in a single model without compromising segmentation accuracy.

Qisheng He, Nicholas Summerfield, Peiyong Wang et al.

Recent studies have shown that diffusion models produce superior synthetic images when compared to Generative Adversarial Networks (GANs). However, their outputs are often non-deterministic and lack high fidelity to the ground truth due to the inherent randomness. In this paper, we propose a novel High-fidelity Brownian bridge model (HiFi-BBrg) for deterministic medical image translations. Our model comprises two distinct yet mutually beneficial mappings: a generation mapping and a reconstruction mapping. The Brownian bridge training process is guided by the fidelity loss and adversarial training in the reconstruction mapping. This ensures that translated images can be accurately reversed to their original forms, thereby achieving consistent translations with high fidelity to the ground truth. Our extensive experiments on multiple datasets show HiFi-BBrg outperforms state-of-the-art methods in multi-modal image translation and multi-image super-resolution.