Daniel O’Neill

Marco Levorato, Daniel O'Neill, Andrea Goldsmith et al.

We study optimal transmission strategies in interfering wireless networks, under Quality of Service constraints. A buffered, dynamic network with multiple sources is considered, and sources use a retransmission strategy in order to improve packet delivery probability. The optimization problem is formulated as a Markov Decision Process, where constraints and objective functions are ratios of time-averaged cost functions. The optimal strategy is found as the solution of a Linear Fractional Program, where the optimization variables are the steady-state probability of state-action pairs. Numerical results illustrate the dependence of optimal transmission/interference strategies on the constraints imposed on the network.

Allan Zhou, Nicholas C. Landolfi, Daniel C. O'Neill

There is considerable interest in predicting the pathogenicity of protein variants in human genes. Due to the sparsity of high quality labels, recent approaches turn to \textit{unsupervised} learning, using Multiple Sequence Alignments (MSAs) to train generative models of natural sequence variation within each gene. These generative models then predict variant likelihood as a proxy to evolutionary fitness. In this work we instead combine this evolutionary principle with pretrained protein language models (LMs), which have already shown promising results in predicting protein structure and function. Instead of training separate models per-gene, we find that a single protein LM trained on broad sequence datasets can score pathogenicity for any gene variant zero-shot, without MSAs or finetuning. We call this unsupervised approach \textbf{VELM} (Variant Effect via Language Models), and show that it achieves scoring performance comparable to the state of the art when evaluated on clinically labeled variants of disease-related genes.

Zheng Wen, Daniel O'Neill, Hamid Reza Maei

Demand response (DR) for residential and small commercial buildings is estimated to account for as much as 65% of the total energy savings potential of DR, and previous work shows that a fully automated Energy Management System (EMS) is a necessary prerequisite to DR in these areas. In this paper, we propose a novel EMS formulation for DR problems in these sectors. Specifically, we formulate a fully automated EMS's rescheduling problem as a reinforcement learning (RL) problem, and argue that this RL problem can be approximately solved by decomposing it over device clusters. Compared with existing formulations, our new formulation (1) does not require explicitly modeling the user's dissatisfaction on job rescheduling, (2) enables the EMS to self-initiate jobs, (3) allows the user to initiate more flexible requests and (4) has a computational complexity linear in the number of devices. We also demonstrate the simulation results of applying Q-learning, one of the most popular and classical RL algorithms, to a representative example.