Yunlong Zhao

Chengpeng Hu, Yunlong Zhao, Ziqi Wang et al.

Games have been the perfect test-beds for artificial intelligence research for the characteristics that widely exist in real-world scenarios. Learning and optimisation, decision making in dynamic and uncertain environments, game theory, planning and scheduling, design and education are common research areas shared between games and real-world problems. Numerous open-source games or game-based environments have been implemented for studying artificial intelligence. In addition to single- or multi-player, collaborative or adversarial games, there has also been growing interest in implementing platforms for creative design in recent years. Those platforms provide ideal benchmarks for exploring and comparing artificial intelligence ideas and techniques. This paper reviews the games and game-based platforms for artificial intelligence research, provides guidance on matching particular types of artificial intelligence with suitable games for testing and matching particular needs in games with suitable artificial intelligence techniques, discusses the research trend induced by the evolution of those games and platforms, and gives an outlook.

Qianqian Dong, Zhiying Huang, Qiao Tian et al.

We propose PolyVoice, a language model-based framework for speech-to-speech translation (S2ST) system. Our framework consists of two language models: a translation language model and a speech synthesis language model. We use discretized speech units, which are generated in a fully unsupervised way, and thus our framework can be used for unwritten languages. For the speech synthesis part, we adopt the existing VALL-E X approach and build a unit-based audio language model. This grants our framework the ability to preserve the voice characteristics and the speaking style of the original speech. We examine our system on Chinese $\rightarrow$ English and English $\rightarrow$ Spanish pairs. Experimental results show that our system can generate speech with high translation quality and audio quality. Speech samples are available at https://speechtranslation.github.io/polyvoice.

Kexin Wang, Yunlong Zhao, Qianqian Dong et al.

As a subjective metric to evaluate the quality of synthesized speech, Mean opinion score~(MOS) usually requires multiple annotators to score the same speech. Such an annotation approach requires a lot of manpower and is also time-consuming. MOS prediction model for automatic evaluation can significantly reduce labor cost. In previous works, it is difficult to accurately rank the quality of speech when the MOS scores are close. However, in practical applications, it is more important to correctly rank the quality of synthesis systems or sentences than simply predicting MOS scores. Meanwhile, as each annotator scores multiple audios during annotation, the score is probably a relative value based on the first or the first few speech scores given by the annotator. Motivated by the above two points, we propose a general framework for MOS prediction based on pair comparison (MOSPC), and we utilize C-Mixup algorithm to enhance the generalization performance of MOSPC. The experiments on BVCC and VCC2018 show that our framework outperforms the baselines on most of the correlation coefficient metrics, especially on the metric KTAU related to quality ranking. And our framework also surpasses the strong baseline in ranking accuracy on each fine-grained segment. These results indicate that our framework contributes to improving the ranking accuracy of speech quality.

Zhenqiao Song, Yunlong Zhao, Wenxian Shi et al.

Proteins are macromolecules responsible for essential functions in almost all living organisms. Designing reasonable proteins with desired functions is crucial. A protein's sequence and structure are strongly correlated and they together determine its function. In this paper, we propose NAEPro, a model to jointly design Protein sequence and structure based on automatically detected functional sites. NAEPro is powered by an interleaving network of attention and equivariant layers, which can capture global correlation in a whole sequence and local influence from nearest amino acids in three dimensional (3D) space. Such an architecture facilitates effective yet economic message passing at two levels. We evaluate our model and several strong baselines on two protein datasets, $β$-lactamase and myoglobin. Experimental results show that our model consistently achieves the highest amino acid recovery rate, TM-score, and the lowest RMSD among all competitors. These findings prove the capability of our model to design protein sequences and structures that closely resemble their natural counterparts. Furthermore, in-depth analysis further confirms our model's ability to generate highly effective proteins capable of binding to their target metallocofactors. We provide code, data and models in Github.

Zhenqiao Song, Yunlong Zhao, Yufei Song et al.

Designing novel proteins with desired functions is crucial in biology and chemistry. However, most existing work focus on protein sequence design, leaving protein sequence and structure co-design underexplored. In this paper, we propose GeoPro, a method to design protein backbone structure and sequence jointly. Our motivation is that protein sequence and its backbone structure constrain each other, and thus joint design of both can not only avoid nonfolding and misfolding but also produce more diverse candidates with desired functions. To this end, GeoPro is powered by an equivariant encoder for three-dimensional (3D) backbone structure and a protein sequence decoder guided by 3D geometry. Experimental results on two biologically significant metalloprotein datasets, including $β$-lactamases and myoglobins, show that our proposed GeoPro outperforms several strong baselines on most metrics. Remarkably, our method discovers novel $β$-lactamases and myoglobins which are not present in protein data bank (PDB) and UniProt. These proteins exhibit stable folding and active site environments reminiscent of those of natural proteins, demonstrating their excellent potential to be biologically functional.

Cong Wan, Xiangyang Luo, Hao Luo et al.

Visual generation has witnessed remarkable progress in single-image tasks, yet extending these capabilities to temporal sequences remains challenging. Current approaches either build specialized video models from scratch with enormous computational costs or add separate motion modules to image generators, both requiring learning temporal dynamics anew. We observe that modern image generation models possess underutilized potential in handling structured layouts with implicit temporal understanding. Building on this insight, we introduce GRID, which reformulates temporal sequences as grid layouts, enabling holistic processing of visual sequences while leveraging existing model capabilities. Through a parallel flow-matching training strategy with coarse-to-fine scheduling, our approach achieves up to 67 faster inference speeds while using <1/1000 of the computational resources compared to specialized models. Extensive experiments demonstrate that GRID not only excels in temporal tasks from Text-to-Video to 3D Editing but also preserves strong performance in image generation, establishing itself as an efficient and versatile omni-solution for visual generation.