Euiheon Chung

Ripon Kumar Saha, A. M. Mahmud Chowdhury, Kyung-Sun Na et al.

Purpose: Develop a deep learning-based automated method to segment meibomian glands (MG) and eyelids, quantitatively analyze the MG area and MG ratio, estimate the meiboscore, and remove specular reflections from infrared images. Methods: A total of 1600 meibography images were captured in a clinical setting. 1000 images were precisely annotated with multiple revisions by investigators and graded 6 times by meibomian gland dysfunction (MGD) experts. Two deep learning (DL) models were trained separately to segment areas of the MG and eyelid. Those segmentation were used to estimate MG ratio and meiboscores using a classification-based DL model. A generative adversarial network was implemented to remove specular reflections from original images. Results: The mean ratio of MG calculated by investigator annotation and DL segmentation was consistent 26.23% vs 25.12% in the upper eyelids and 32.34% vs. 32.29% in the lower eyelids, respectively. Our DL model achieved 73.01% accuracy for meiboscore classification on validation set and 59.17% accuracy when tested on images from independent center, compared to 53.44% validation accuracy by MGD experts. The DL-based approach successfully removes reflection from the original MG images without affecting meiboscore grading. Conclusions: DL with infrared meibography provides a fully automated, fast quantitative evaluation of MG morphology (MG Segmentation, MG area, MG ratio, and meiboscore) which are sufficiently accurate for diagnosing dry eye disease. Also, the DL removes specular reflection from images to be used by ophthalmologists for distraction-free assessment.

Moon Hwan Lee, Mohd. Afzal Khan, Akm Ashiquzzaman et al.

Acoustic holography provides a practical means of flexibly controlling acoustic wavefronts. However, high-fidelity shaping of acoustic fields remains constrained by the numerical-physical gap inherent in conventional phase-only designs. These approaches realize a two-dimensional phase-delay profile as a three-dimensional thickness-varying lens, while neglecting wave-matter interactions arising from the lens structure. Here, we introduce an end-to-end, physics-aware differentiable structural optimization framework that directly incorporates three-dimensional lens geometries into the acoustic simulation and optimization loop. Using a novel differentiable relaxation, termed Differentiable Hologram Lens Approximation (DHLA), the lens geometry is treated as a differentiable design variable, ensuring intrinsic consistency between numerical design and physical realization. The resulting Thickness-Only Acoustic Holograms (TOAHs) significantly outperform state-of-the-art phase-only acoustic holograms (POAHs) in field reconstruction fidelity and precision under complex conditions. We further demonstrate the application of the framework to spatially selective neuromodulation in a neuropathic pain mouse model, highlighting its potential for non-invasive transcranial neuromodulation. In summary, by reconciling numerical design with physical realization, this work establishes a robust strategy for high-fidelity acoustic wavefront shaping in complex environments.