Marius Pedersen

Ying Xu, Kiran Raja, Luisa Verdoliva et al.

A fast-paced development of DeepFake generation techniques challenge the detection schemes designed for known type DeepFakes. A reliable Deepfake detection approach must be agnostic to generation types, which can present diverse quality and appearance. Limited generalizability across different generation schemes will restrict the wide-scale deployment of detectors if they fail to handle unseen attacks in an open set scenario. We propose a new approach, Multi-Channel Xception Attention Pairwise Interaction (MCX-API), that exploits the power of pairwise learning and complementary information from different color space representations in a fine-grained manner. We first validate our idea on a publicly available dataset in a intra-class setting (closed set) with four different Deepfake schemes. Further, we report all the results using balanced-open-set-classification (BOSC) accuracy in an inter-class setting (open-set) using three public datasets. Our experiments indicate that our proposed method can generalize better than the state-of-the-art Deepfakes detectors. We obtain 98.48% BOSC accuracy on the FF++ dataset and 90.87% BOSC accuracy on the CelebDF dataset suggesting a promising direction for generalization of DeepFake detection. We further utilize t-SNE and attention maps to interpret and visualize the decision-making process of our proposed network. https://github.com/xuyingzhongguo/MCX-API

Ying Xu, Philipp Terhörst, Kiran Raja et al.

In recent years, image and video manipulations with Deepfake have become a severe concern for security and society. Many detection models and datasets have been proposed to detect Deepfake data reliably. However, there is an increased concern that these models and training databases might be biased and, thus, cause Deepfake detectors to fail. In this work, we investigate factors causing biased detection in public Deepfake datasets by (a) creating large-scale demographic and non-demographic attribute annotations with 47 different attributes for five popular Deepfake datasets and (b) comprehensively analysing attributes resulting in AI-bias of three state-of-the-art Deepfake detection backbone models on these datasets. The analysis shows how various attributes influence a large variety of distinctive attributes (from over 65M labels) on the detection performance which includes demographic (age, gender, ethnicity) and non-demographic (hair, skin, accessories, etc.) attributes. The results examined datasets show limited diversity and, more importantly, show that the utilised Deepfake detection backbone models are strongly affected by investigated attributes making them not fair across attributes. The Deepfake detection backbone methods trained on such imbalanced/biased datasets result in incorrect detection results leading to generalisability, fairness, and security issues. Our findings and annotated datasets will guide future research to evaluate and mitigate bias in Deepfake detection techniques. The annotated datasets and the corresponding code are publicly available.

Anuja Vats, Marius Pedersen, Ahmed Mohammed et al.

Wireless Capsule Endoscopy (WCE) is being increasingly used as an alternative imaging modality for complete and non-invasive screening of the gastrointestinal tract. Although this is advantageous in reducing unnecessary hospital admissions, it also demands that a WCE diagnostic protocol be in place so larger populations can be effectively screened. This calls for training and education protocols attuned specifically to this modality. Like training in other modalities such as traditional endoscopy, CT, MRI, etc., a WCE training protocol would require an atlas comprising of a large corpora of images that show vivid descriptions of pathologies and abnormalities, ideally observed over a period of time. Since such comprehensive atlases are presently lacking in WCE, in this work, we propose a deep learning method for utilizing already available studies across different institutions for the creation of a realistic WCE atlas using StyleGAN. We identify clinically relevant attributes in WCE such that synthetic images can be generated with selected attributes on cue. Beyond this, we also simulate several disease progression scenarios. The generated images are evaluated for realism and plausibility through three subjective online experiments with the participation of eight gastroenterology experts from three geographical locations and a variety of years of experience. The results from the experiments indicate that the images are highly realistic and the disease scenarios plausible. The images comprising the atlas are available publicly for use in training applications as well as supplementing real datasets for deep learning.

Anuja Vats, Ahmed Mohammed, Marius Pedersen et al.

Due to the unequivocal need for understanding the decision processes of deep learning networks, both modal-dependent and model-agnostic techniques have become very popular. Although both of these ideas provide transparency for automated decision making, most methodologies focus on either using the modal-gradients (model-dependent) or ignoring the model internal states and reasoning with a model's behavior/outcome (model-agnostic) to instances. In this work, we propose a unified explanation approach that given an instance combines both model-dependent and agnostic explanations to produce an explanation set. The generated explanations are not only consistent in the neighborhood of a sample but can highlight causal relationships between image content and the outcome. We use Wireless Capsule Endoscopy (WCE) domain to illustrate the effectiveness of our explanations. The saliency maps generated by our approach are comparable or better on the softmax information score.

Anuja Vats, Ahmed Mohammed, Marius Pedersen

The lack of generalizability of deep learning approaches for the automated diagnosis of pathologies in Wireless Capsule Endoscopy (WCE) has prevented any significant advantages from trickling down to real clinical practices. As a result, disease management using WCE continues to depend on exhaustive manual investigations by medical experts. This explains its limited use despite several advantages. Prior works have considered using higher quality and quantity of labels as a way of tackling the lack of generalization, however this is hardly scalable considering pathology diversity not to mention that labeling large datasets encumbers the medical staff additionally. We propose using freely available domain knowledge as priors to learn more robust and generalizable representations. We experimentally show that domain priors can benefit representations by acting in proxy of labels, thereby significantly reducing the labeling requirement while still enabling fully unsupervised yet pathology-aware learning. We use the contrastive objective along with prior-guided views during pretraining, where the view choices inspire sensitivity to pathological information. Extensive experiments on three datasets show that our method performs better than (or closes gap with) the state-of-the-art in the domain, establishing a new benchmark in pathology classification and cross-dataset generalization, as well as scaling to unseen pathology categories.

Pål Anders Floor, Ivar Farup, Marius Pedersen

As the number of people affected by diseases in the gastrointestinal system is ever-increasing, a higher demand on preventive screening is inevitable. This will significantly increase the workload on gastroenterologists. To help reduce the workload, tools from computer vision may be helpful. In this paper, we investigate the possibility of constructing 3D models of whole sections of the human colon using image sequences from wireless capsule endoscope video, providing enhanced viewing for gastroenterologists. As capsule endoscope images contain distortion and artifacts non-ideal for many 3D reconstruction algorithms, the problem is challenging. However, recent developments of virtual graphics-based models of the human gastrointestinal system, where distortion and artifacts can be enabled or disabled, makes it possible to ``dissect'' the problem. The graphical model also provides a ground truth, enabling computation of geometric distortion introduced by the 3D reconstruction method. In this paper, most distortions and artifacts are left out to determine if it is feasible to reconstruct whole sections of the human gastrointestinal system by existing methods. We demonstrate that 3D reconstruction is possible using simultaneous localization and mapping. Further, to reconstruct the gastrointestinal wall surface from resulting point clouds, varying greatly in density, Poisson surface reconstruction is a good option. The results are promising, encouraging further research on this problem.

Anuja Vats, David Völgyes, Martijn Vermeer et al.

Estimating building footprint maps from geospatial data is of paramount importance in urban planning, development, disaster management, and various other applications. Deep learning methodologies have gained prominence in building segmentation maps, offering the promise of precise footprint extraction without extensive post-processing. However, these methods face challenges in generalization and label efficiency, particularly in remote sensing, where obtaining accurate labels can be both expensive and time-consuming. To address these challenges, we propose terrain-aware self-supervised learning, tailored to remote sensing, using digital elevation models from LiDAR data. We propose to learn a model to differentiate between bare Earth and superimposed structures enabling the network to implicitly learn domain-relevant features without the need for extensive pixel-level annotations. We test the effectiveness of our approach by evaluating building segmentation performance on test datasets with varying label fractions. Remarkably, with only 1% of the labels (equivalent to 25 labeled examples), our method improves over ImageNet pre-training, showing the advantage of leveraging unlabeled data for feature extraction in the domain of remote sensing. The performance improvement is more pronounced in few-shot scenarios and gradually closes the gap with ImageNet pre-training as the label fraction increases. We test on a dataset characterized by substantial distribution shifts and labeling errors to demonstrate the generalizability of our approach. When compared to other baselines, including ImageNet pretraining and more complex architectures, our approach consistently performs better, demonstrating the efficiency and effectiveness of self-supervised terrain-aware feature learning.

Bidossessi Emmanuel Agossou, Marius Pedersen, Kiran Raja et al.

Pathology detection in Wireless Capsule Endoscopy (WCE) using deep learning has been explored in the recent past. However, deep learning models can be influenced by the color quality of the dataset used to train them, impacting detection, segmentation and classification tasks. In this work, we evaluate the impact of color correction on pathology detection using two prominent object detection models: Retinanet and YOLOv5. We first generate two color corrected versions of a popular WCE dataset (i.e., SEE-AI dataset) using two different color correction functions. We then evaluate the performance of the Retinanet and YOLOv5 on the original and color corrected versions of the dataset. The results reveal that color correction makes the models generate larger bounding boxes and larger intersection areas with the ground truth annotations. Furthermore, color correction leads to an increased number of false positives for certain pathologies. However, these effects do not translate into a consistent improvement in performance metrics such as F1-scores, IoU, and AP50. The code is available at https://github.com/agossouema2011/WCE2024. Keywords: Wireless Capsule Endoscopy, Color correction, Retinanet, YOLOv5, Detection

Ying Xu, Marius Pedersen, Kiran Raja

The rapid development of deep learning and generative AI technologies has profoundly transformed the digital contact landscape, creating realistic Deepfake that poses substantial challenges to public trust and digital media integrity. This paper introduces a novel Deepfake detention framework, Volume of Differences (VoD), designed to enhance detection accuracy by exploiting temporal and spatial inconsistencies between consecutive video frames. VoD employs a progressive learning approach that captures differences across multiple axes through the use of consecutive frame differences (CFD) and a network with stepwise expansions. We evaluate our approach with intra-dataset and cross-dataset testing scenarios on various well-known Deepfake datasets. Our findings demonstrate that VoD excels with the data it has been trained on and shows strong adaptability to novel, unseen data. Additionally, comprehensive ablation studies examine various configurations of segment length, sampling steps, and intervals, offering valuable insights for optimizing the framework. The code for our VoD framework is available at https://github.com/xuyingzhongguo/VoD.

Anuja Vats, Ivar Farup, Marius Pedersen et al.

The importance of quantifying uncertainty in deep networks has become paramount for reliable real-world applications. In this paper, we propose a method to improve uncertainty estimation in medical Image-to-Image (I2I) translation. Our model integrates aleatoric uncertainty and employs Uncertainty-Aware Regularization (UAR) inspired by simple priors to refine uncertainty estimates and enhance reconstruction quality. We show that by leveraging simple priors on parameters, our approach captures more robust uncertainty maps, effectively refining them to indicate precisely where the network encounters difficulties, while being less affected by noise. Our experiments demonstrate that UAR not only improves translation performance, but also provides better uncertainty estimations, particularly in the presence of noise and artifacts. We validate our approach using two medical imaging datasets, showcasing its effectiveness in maintaining high confidence in familiar regions while accurately identifying areas of uncertainty in novel/ambiguous scenarios.

Harikrishnan N B, Anuja Vats, Nithin Nagaraj et al.

Modern machine learning approaches often prioritize performance at the cost of increased complexity, computational demands, and reduced interpretability. This paper introduces a novel framework that challenges this trend by reinterpreting learning from an information-theoretic perspective, viewing it as a search for encoding schemes that capture intrinsic data structures through compact representations. Rather than following the conventional approach of fitting data to complex models, we propose a fundamentally different method that maps data to intervals of initial conditions in a dynamical system. Our GLS (Generalized Lüroth Series) coding compression classifier employs skew tent maps - a class of chaotic maps - both for encoding data into initial conditions and for subsequent recovery. The effectiveness of this simple framework is noteworthy, with performance closely approaching that of well-established machine learning methods. On the breast cancer dataset, our approach achieves 92.98\% accuracy, comparable to Naive Bayes at 94.74\%. While these results do not exceed state-of-the-art performance, the significance of our contribution lies not in outperforming existing methods but in demonstrating that a fundamentally simpler, more interpretable approach can achieve competitive results.

Anuja Vats, Marius Pedersen, Ahmed Mohammed et al.

The progress in Computer Aided Diagnosis (CADx) of Wireless Capsule Endoscopy (WCE) is thwarted by the lack of data. The inadequacy in richly representative healthy and abnormal conditions results in isolated analyses of pathologies, that can not handle realistic multi-pathology scenarios. In this work, we explore how to learn more for free, from limited data through solving a WCE multicentric, multi-pathology classification problem. Learning more implies to learning more than full supervision would allow with the same data. This is done by combining self supervision with full supervision, under multi task learning. Additionally, we draw inspiration from the Human Visual System (HVS) in designing self supervision tasks and investigate if seemingly ineffectual signals within the data itself can be exploited to gain performance, if so, which signals would be better than others. Further, we present our analysis of the high level features as a stepping stone towards more robust multi-pathology CADx in WCE.

Olivier Rukundo, Marius Pedersen, Øistein Hovde

This paper proposes an advanced method for contrast enhancement of capsule endoscopic images, with the main objective to obtain sufficient information about the vessels and structures in more distant (or darker) parts of capsule endoscopic images. The proposed method (PM) combines two algorithms for the enhancement of darker and brighter areas of capsule endoscopic images, respectively. The half-unit weighted bilinear algorithm (HWB) proposed in our previous work is used to enhance darker areas according to the darker map content of its HSV's component V. Enhancement of brighter areas is achieved thanks to the novel thresholded weighted-bilinear algorithm (TWB) developed to avoid overexposure and enlargement of specular highlight spots while preserving the hue, in such areas. The TWB performs enhancement operations following a gradual increment of the brightness of the brighter map content of its HSV's component V. In other words, the TWB decreases its averaged-weights as the intensity content of the component V increases. Extensive experimental demonstrations were conducted, and based on evaluation of the reference and PM enhanced images, a gastroenterologist (ØH) concluded that the PM enhanced images were the best ones based on the information about the vessels, contrast in the images, and the view or visibility of the structures in more distant parts of the capsule endoscopy images.

Max Allan, Satoshi Kondo, Sebastian Bodenstedt et al.

In 2015 we began a sub-challenge at the EndoVis workshop at MICCAI in Munich using endoscope images of ex-vivo tissue with automatically generated annotations from robot forward kinematics and instrument CAD models. However, the limited background variation and simple motion rendered the dataset uninformative in learning about which techniques would be suitable for segmentation in real surgery. In 2017, at the same workshop in Quebec we introduced the robotic instrument segmentation dataset with 10 teams participating in the challenge to perform binary, articulating parts and type segmentation of da Vinci instruments. This challenge included realistic instrument motion and more complex porcine tissue as background and was widely addressed with modifications on U-Nets and other popular CNN architectures. In 2018 we added to the complexity by introducing a set of anatomical objects and medical devices to the segmented classes. To avoid over-complicating the challenge, we continued with porcine data which is dramatically simpler than human tissue due to the lack of fatty tissue occluding many organs.

Steven Le Moan, Marius Pedersen

Change blindness is a striking shortcoming of our visual system which is exploited in the popular "Spot the difference" game. It makes us unable to notice large visual changes happening right before our eyes and illustrates the fact that we see much less than we think we do. We introduce a fully automated model to predict colour change blindness in cartoon images based on two low-level image features and observer experience. Using linear regression with only three parameters, the predictions of the proposed model correlate significantly with measured detection times. We also demonstrate the efficacy of the model to classify stimuli in terms of difficulty.

Oleksii Sidorov, Marius Pedersen, Nam Wook Kim et al.

In this work, we address the problem of measuring and predicting temporal video saliency - a metric which defines the importance of a video frame for human attention. Unlike the conventional spatial saliency which defines the location of the salient regions within a frame (as it is done for still images), temporal saliency considers importance of a frame as a whole and may not exist apart from context. The proposed interface is an interactive cursor-based algorithm for collecting experimental data about temporal saliency. We collect the first human responses and perform their analysis. As a result, we show that qualitatively, the produced scores have very explicit meaning of the semantic changes in a frame, while quantitatively being highly correlated between all the observers. Apart from that, we show that the proposed tool can simultaneously collect fixations similar to the ones produced by eye-tracker in a more affordable way. Further, this approach may be used for creation of first temporal saliency datasets which will allow training computational predictive algorithms. The proposed interface does not rely on any special equipment, which allows to run it remotely and cover a wide audience.

Ahmed Mohammed, Sule Yildirim, Ivar Farup et al.

Colorectal polyps are important precursors to colon cancer, the third most common cause of cancer mortality for both men and women. It is a disease where early detection is of crucial importance. Colonoscopy is commonly used for early detection of cancer and precancerous pathology. It is a demanding procedure requiring significant amount of time from specialized physicians and nurses, in addition to a significant miss-rates of polyps by specialists. Automated polyp detection in colonoscopy videos has been demonstrated to be a promising way to handle this problem. {However, polyps detection is a challenging problem due to the availability of limited amount of training data and large appearance variations of polyps. To handle this problem, we propose a novel deep learning method Y-Net that consists of two encoder networks with a decoder network. Our proposed Y-Net method} relies on efficient use of pre-trained and un-trained models with novel sum-skip-concatenation operations. Each of the encoders are trained with encoder specific learning rate along the decoder. Compared with the previous methods employing hand-crafted features or 2-D/3-D convolutional neural network, our approach outperforms state-of-the-art methods for polyp detection with 7.3% F1-score and 13% recall improvement.