Peter Yongho Kim

Peter Yongho Kim, Junbeom Kwon, Sunghwan Joo et al.

Modeling spatiotemporal brain dynamics from high-dimensional data, such as functional Magnetic Resonance Imaging (fMRI), is a formidable task in neuroscience. Existing approaches for fMRI analysis utilize hand-crafted features, but the process of feature extraction risks losing essential information in fMRI scans. To address this challenge, we present SwiFT (Swin 4D fMRI Transformer), a Swin Transformer architecture that can learn brain dynamics directly from fMRI volumes in a memory and computation-efficient manner. SwiFT achieves this by implementing a 4D window multi-head self-attention mechanism and absolute positional embeddings. We evaluate SwiFT using multiple large-scale resting-state fMRI datasets, including the Human Connectome Project (HCP), Adolescent Brain Cognitive Development (ABCD), and UK Biobank (UKB) datasets, to predict sex, age, and cognitive intelligence. Our experimental outcomes reveal that SwiFT consistently outperforms recent state-of-the-art models. Furthermore, by leveraging its end-to-end learning capability, we show that contrastive loss-based self-supervised pre-training of SwiFT can enhance performance on downstream tasks. Additionally, we employ an explainable AI method to identify the brain regions associated with sex classification. To our knowledge, SwiFT is the first Swin Transformer architecture to process dimensional spatiotemporal brain functional data in an end-to-end fashion. Our work holds substantial potential in facilitating scalable learning of functional brain imaging in neuroscience research by reducing the hurdles associated with applying Transformer models to high-dimensional fMRI.

Peter Yongho Kim, Juhyeon Park, Jungwoo Park et al.

Modeling long-range spatiotemporal dynamics in functional Magnetic Resonance Imaging (fMRI) remains a key challenge due to the high dimensionality of the four-dimensional signals. Prior voxel-based models, although demonstrating excellent performance and interpretation capabilities, are constrained by prohibitive memory demands and thus can only capture limited temporal windows. To address this, we propose TABLeT (Two-dimensionally Autoencoded Brain Latent Transformer), a novel approach that tokenizes fMRI volumes using a pre-trained 2D natural image autoencoder. Each 3D fMRI volume is compressed into a compact set of continuous tokens, enabling long-sequence modeling with a simple Transformer encoder with limited VRAM. Across large-scale benchmarks including the UK-Biobank (UKB), Human Connectome Project (HCP), and ADHD-200 datasets, TABLeT outperforms existing models in multiple tasks, while demonstrating substantial gains in computational and memory efficiency over the state-of-the-art voxel-based method given the same input. Furthermore, we develop a self-supervised masked token modeling approach to pre-train TABLeT, which improves the model's performance for various downstream tasks. Our findings suggest a promising approach for scalable and interpretable spatiotemporal modeling of brain activity. Our code is available at https://github.com/beotborry/TABLeT.

Juhyeon Park, Peter Yongho Kim, Jiook Cha et al.

We present SEED (\textbf{Se}mantic \textbf{E}valuation for Visual Brain \textbf{D}ecoding), a novel metric for evaluating the semantic decoding performance of visual brain decoding models. It integrates three complementary metrics, each capturing a different aspect of semantic similarity between images. Using carefully crowd-sourced human judgment data, we demonstrate that SEED achieves the highest alignment with human evaluations, outperforming other widely used metrics. Through the evaluation of existing visual brain decoding models, we further reveal that crucial information is often lost in translation, even in state-of-the-art models that achieve near-perfect scores on existing metrics. To facilitate further research, we open-source the human judgment data, encouraging the development of more advanced evaluation methods for brain decoding models. Additionally, we propose a novel loss function designed to enhance semantic decoding performance by leveraging the order of pairwise cosine similarity in CLIP image embeddings. This loss function is compatible with various existing methods and has been shown to consistently improve their semantic decoding performances when used for training, with respect to both existing metrics and SEED.