Davide Bianchi

Davide Bianchi, Sonia Colombo Serra, Davide Evangelista et al.

The adoption of contrast agents in medical imaging protocols is crucial for accurate and timely diagnosis. While highly effective and characterized by an excellent safety profile, the use of contrast agents has its limitation, including rare risk of allergic reactions, potential environmental impact and economic burdens on patients and healthcare systems. In this work, we address the contrast agent reduction (CAR) problem, which involves reducing the administered dosage of contrast agent while preserving the visual enhancement. The current literature on the CAR task is based on deep learning techniques within a fully image processing framework. These techniques digitally simulate high-dose images from images acquired with a low dose of contrast agent. We investigate the feasibility of a ``learned inverse problem'' (LIP) approach, as opposed to the end-to-end paradigm in the state-of-the-art literature. Specifically, we learn the image-to-image operator that maps high-dose images to their corresponding low-dose counterparts, and we frame the CAR task as an inverse problem. We then solve this problem through a regularized optimization reformulation. Regularization methods are well-established mathematical techniques that offer robustness and explainability. Our approach combines these rigorous techniques with cutting-edge deep learning tools. Numerical experiments performed on pre-clinical medical images confirm the effectiveness of this strategy, showing improved stability and accuracy in the simulated high-dose images.

Davide Bianchi, Florian Bossmann, Wenlong Wang et al.

We introduce a data-adaptive inversion method that integrates classical or deep learning-based approaches with iterative graph Laplacian regularization, specifically targeting acoustic impedance inversion - a critical task in seismic exploration. Our method initiates from an impedance estimate derived using either traditional inversion techniques or neural network-based methods. This initial estimate guides the construction of a graph Laplacian operator, effectively capturing structural characteristics of the impedance profile. Utilizing a Tikhonov-inspired variational framework with this graph-informed prior, our approach iteratively updates and refines the impedance estimate while continuously recalibrating the graph Laplacian. This iterative refinement shows rapid convergence, increased accuracy, and enhanced robustness to noise compared to initial reconstructions alone. Extensive validation performed on synthetic and real seismic datasets across varying noise levels confirms the effectiveness of our method. Performance evaluations include four initial inversion methods: two classical techniques and two neural networks - previously established in the literature.