Ruotai Li

Yehan Yang, Tianhao Ma, Ruotai Li et al.

The effective application of traditional Chinese medicine (TCM) requires extensive knowledge of TCM and clinical experience. The emergence of Large Language Models (LLMs) provides a solution to this, while existing LLMs for TCM exhibit critical limitations of incomplete clinical consultation and diagnoses, as well as inaccurate syndrome differentiation. To address these issues, we establish JingFang (JF), a novel TCM LLM that demonstrates the level of expertise in clinical consultation and syndrome differentiation. We propose a Multi-Agent Collaborative Chain-of-Thought Mechanism (MACCTM) for comprehensive and targeted clinical consultation, enabling JF with effective and accurate diagnostic ability. In addition, a Syndrome Agent and a Dual-Stage Recovery Scheme (DSRS) are developed to accurately enhance the differentiation of the syndrome and the subsequent corresponding treatment. JingFang not only facilitates the application of LLMs but also promotes the effective application of TCM for healthcare.

Xinhan Zheng, Huyu Wu, Haopeng Jin et al.

Traditional Chinese medicine (TCM) exhibits remarkable therapeutic efficacy in disease treatment and healthcare through personalized herb prescriptions. However, current herb recommendation models inadequately capture the multiscale relations between herbs and clinical symptoms, particularly neglecting latent correlations at the chemical-molecular scale. To address these limitations, we propose the Fusion of Multiscale Correlations of Herbs and Symptoms (FMCHS), an innovative framework that synergistically integrates molecular-scale chemical characteristics of herbs with clinical symptoms. The framework employs multi-relational graph transformer layers to generate enriched embeddings that preserve both structural and semantic features within herbs and symptoms. Through systematic incorporation of herb chemical profiles into node embeddings and implementation of attention-based feature fusion, FMCHS effectively utilizes multiscale correlations. Comprehensive evaluations demonstrate FMCHS's superior performance over the state-of-the-art (SOTA) baseline, achieving relative improvements of 8.85% in Precision@5, 12.30% in Recall@5, and 10.86% in F1@5 compared to the SOTA model on benchmark datasets. This work facilitates the practical application of TCM in disease treatment and healthcare.