Calvin Yu‐Chian Chen

Guian Fang, Mengsha Liu, Yi Zhong et al.

Alzheimer's disease is a progressive neurological disorder characterized by cognitive impairment and memory loss. With the increasing aging population, the incidence of AD is continuously rising, making early diagnosis and intervention an urgent need. In recent years, a considerable number of teams have applied computer-aided diagnostic techniques to early classification research of AD. Most studies have utilized imaging modalities such as magnetic resonance imaging (MRI), positron emission tomography (PET), and electroencephalogram (EEG). However, there have also been studies that attempted to use other modalities as input features for the models, such as sound, posture, biomarkers, cognitive assessment scores, and their fusion. Experimental results have shown that the combination of multiple modalities often leads to better performance compared to a single modality. Therefore, this paper will focus on different modalities and their fusion, thoroughly elucidate the mechanisms of various modalities, explore which methods should be combined to better harness their utility, analyze and summarize the literature in the field of early classification of AD in recent years, in order to explore more possibilities of modality combinations.

Bingxi Liu, Calvin Chen, Junhao Li et al.

The Vision Transformer (ViT) model has long struggled with the challenge of quadratic complexity, a limitation that becomes especially critical in unmanned aerial vehicle (UAV) tracking systems, where data must be processed in real time. In this study, we explore the recently proposed State-Space Model, Mamba, leveraging its computational efficiency and capability for long-sequence modeling to effectively process dense image sequences in tracking tasks. First, we highlight the issue of temporal inconsistency in existing Mamba-based methods, specifically the failure to account for temporal continuity in the Mamba scanning mechanism. Secondly, building upon this insight,we propose TrackingMiM, a Mamba-in-Mamba architecture, a minimal-computation burden model for handling image sequence of tracking problem. In our framework, the mamba scan is performed in a nested way while independently process temporal and spatial coherent patch tokens. While the template frame is encoded as query token and utilized for tracking in every scan. Extensive experiments conducted on five UAV tracking benchmarks confirm that the proposed TrackingMiM achieves state-of-the-art precision while offering noticeable higher speed in UAV tracking.

Chengpeng Hu, Calvin Yu-Chian Chen

Artificial Intelligence Virtual Cells (AIVCs) aim to learn executable, decision-relevant models of cell state from multimodal, multiscale measurements. Recent studies have introduced single-cell and spatial foundation models, improved cross-modality alignment, scaled perturbation atlases, and explored pathway-level readouts. Nevertheless, although held-out validation is standard practice, evaluations remain predominantly within single datasets and settings; evidence indicates that transport across laboratories and platforms is often limited, that some data splits are vulnerable to leakage and coverage bias, and that dose, time and combination effects are not yet systematically handled. Cross-scale coupling also remains constrained, as anchors linking molecular, cellular and tissue levels are sparse, and alignment to scientific or clinical readouts varies across studies. We propose a model-agnostic Cell-State Latent (CSL) perspective that organizes learning via an operator grammar: measurement, lift/project for cross-scale coupling, and intervention for dosing and scheduling. This view motivates a decision-aligned evaluation blueprint across modality, scale, context and intervention, and emphasizes function-space readouts such as pathway activity, spatial neighborhoods and clinically relevant endpoints. We recommend operator-aware data design, leakage-resistant partitions, and transparent calibration and reporting to enable reproducible, like-for-like comparisons.

Hao Yang, Tao Tan, Shuai Tan et al.

Modelling disease progression in precision medicine requires capturing complex spatio-temporal dynamics while preserving anatomical integrity. Existing methods often struggle with longitudinal dependencies and structural consistency in progressive disorders. To address these limitations, we introduce MambaControl, a novel framework that integrates selective state-space modelling with diffusion processes for high-fidelity prediction of medical image trajectories. To better capture subtle structural changes over time while maintaining anatomical consistency, MambaControl combines Mamba-based long-range modelling with graph-guided anatomical control to more effectively represent anatomical correlations. Furthermore, we introduce Fourier-enhanced spectral graph representations to capture spatial coherence and multiscale detail, enabling MambaControl to achieve state-of-the-art performance in Alzheimer's disease prediction. Quantitative and regional evaluations demonstrate improved progression prediction quality and anatomical fidelity, highlighting its potential for personalised prognosis and clinical decision support.

Yichao Zhou, Chelsea Ju, J. Harry Caufield et al.

The clinical named entity recognition (CNER) task seeks to locate and classify clinical terminologies into predefined categories, such as diagnostic procedure, disease disorder, severity, medication, medication dosage, and sign symptom. CNER facilitates the study of side-effect on medications including identification of novel phenomena and human-focused information extraction. Existing approaches in extracting the entities of interests focus on using static word embeddings to represent each word. However, one word can have different interpretations that depend on the context of the sentences. Evidently, static word embeddings are insufficient to integrate the diverse interpretation of a word. To overcome this challenge, the technique of contextualized word embedding has been introduced to better capture the semantic meaning of each word based on its context. Two of these language models, ELMo and Flair, have been widely used in the field of Natural Language Processing to generate the contextualized word embeddings on domain-generic documents. However, these embeddings are usually too general to capture the proximity among vocabularies of specific domains. To facilitate various downstream applications using clinical case reports (CCRs), we pre-train two deep contextualized language models, Clinical Embeddings from Language Model (C-ELMo) and Clinical Contextual String Embeddings (C-Flair) using the clinical-related corpus from the PubMed Central. Explicit experiments show that our models gain dramatic improvements compared to both static word embeddings and domain-generic language models.