Yasha Wang

Ruizhe Zhang, Yongxin Xu, Yuzhen Xiao et al.

By integrating external knowledge, Retrieval-Augmented Generation (RAG) has become an effective strategy for mitigating the hallucination problems that large language models (LLMs) encounter when dealing with knowledge-intensive tasks. However, in the process of integrating external non-parametric supporting evidence with internal parametric knowledge, inevitable knowledge conflicts may arise, leading to confusion in the model's responses. To enhance the knowledge selection of LLMs in various contexts, some research has focused on refining their behavior patterns through instruction-tuning. Nonetheless, due to the absence of explicit negative signals and comparative objectives, models fine-tuned in this manner may still exhibit undesirable behaviors such as contextual ignorance and contextual overinclusion. To this end, we propose a Knowledge-aware Preference Optimization strategy, dubbed KnowPO, aimed at achieving adaptive knowledge selection based on contextual relevance in real retrieval scenarios. Concretely, we proposed a general paradigm for constructing knowledge conflict datasets, which comprehensively cover various error types and learn how to avoid these negative signals through preference optimization methods. Simultaneously, we proposed a rewriting strategy and data ratio optimization strategy to address preference imbalances. Experimental results show that KnowPO outperforms previous methods for handling knowledge conflicts by over 37\%, while also exhibiting robust generalization across various out-of-distribution datasets.

Hongxin Ding, Yue Fang, Runchuan Zhu et al.

Large Language Models(LLMs) excel in general tasks but struggle in specialized domains like healthcare due to limited domain-specific knowledge.Supervised Fine-Tuning(SFT) data construction for domain adaptation often relies on heuristic methods, such as GPT-4 annotation or manual data selection, with a data-centric focus on presumed diverse, high-quality datasets. However, these methods overlook the model's inherent knowledge distribution, introducing noise, redundancy, and irrelevant data, leading to a mismatch between the selected data and the model's learning task, resulting in suboptimal performance. To address this, we propose a two-stage model-centric data selection framework, Decomposed Difficulty Data Selection (3DS), which aligns data with the model's knowledge distribution for optimized adaptation. In Stage1, we apply Prompt-Driven Data Selection via Explicit Alignment, where the the model filters irrelevant or redundant data based on its internal knowledge. In Stage2, we perform Decomposed Difficulty Data Selection, where data selection is guided by our defined difficulty decomposition, using three metrics: Instruction Understanding, Response Confidence, and Response Correctness. Additionally, an attention-based importance weighting mechanism captures token importance for more accurate difficulty calibration. This two-stage approach ensures the selected data is not only aligned with the model's knowledge and preferences but also appropriately challenging for the model to learn, leading to more effective and targeted domain adaptation. In the case study of the medical domain, our extensive experiments on real-world healthcare datasets demonstrate the superiority of 3DS over exisiting methods in accuracy by over 5.29%. Our dataset and code has been open-sourced at https://github.com/PuppyKnightUniversity/3DS.

Yue Fang, Yuxin Guo, Jiaran Gao et al.

Improving large language models (LLMs) for electronic health record (EHR) reasoning is essential for enabling accurate and generalizable clinical predictions. While LLMs excel at medical text understanding, they underperform on EHR-based prediction tasks due to challenges in modeling temporally structured, high-dimensional data. Existing approaches often rely on hybrid paradigms, where LLMs serve merely as frozen prior retrievers while downstream deep learning (DL) models handle prediction, failing to improve the LLM's intrinsic reasoning capacity and inheriting the generalization limitations of DL models. To this end, we propose EAG-RL, a novel two-stage training framework designed to intrinsically enhance LLMs' EHR reasoning ability through expert attention guidance, where expert EHR models refer to task-specific DL models trained on EHR data. Concretely, EAG-RL first constructs high-quality, stepwise reasoning trajectories using expert-guided Monte Carlo Tree Search to effectively initialize the LLM's policy. Then, EAG-RL further optimizes the policy via reinforcement learning by aligning the LLM's attention with clinically salient features identified by expert EHR models. Extensive experiments on two real-world EHR datasets show that EAG-RL improves the intrinsic EHR reasoning ability of LLMs by an average of 14.62%, while also enhancing robustness to feature perturbations and generalization to unseen clinical domains. These results demonstrate the practical potential of EAG-RL for real-world deployment in clinical prediction tasks. Our code have been available at https://github.com/devilran6/EAG-RL.

Zhibang Yang, Xinke Jiang, Rihong Qiu et al.

Federated Retrieval (FR) routes queries across multiple external knowledge sources, to mitigate hallucinations of LLMs, when necessary external knowledge is distributed. However, existing methods struggle to retrieve high-quality and relevant documents for ambiguous queries, especially in cross-domain scenarios, which significantly limits their effectiveness in supporting downstream generation tasks. Inspired by Dynamic Information Flow (DIF), we propose DFAMS, a novel framework that leverages DIF to identify latent query intents and construct semantically aligned knowledge partitions for accurate retrieval across heterogeneous sources. Specifically, DFAMS probes the DIF in LLMs by leveraging gradient signals from a few annotated queries and employing Shapley value-based attribution to trace neuron activation paths associated with intent recognition and subdomain boundary detection. Then, DFAMS leverages DIF to train an alignment module via multi-prototype contrastive learning, enabling fine-grained intra-source modeling and inter-source semantic alignment across knowledge bases. Experimental results across five benchmarks show that DFAMS outperforms advanced FR methods by up to 14.37\% in knowledge classification accuracy, 5.38\% in retrieval recall, and 6.45\% in downstream QA accuracy, demonstrating its effectiveness in complex FR scenarios. Our code are anonymous available at https://anonymous.4open.science/r/DFAMS/

Xinke Jiang, Ruizhe Zhang, Yongxin Xu et al.

In this paper, we investigate the retrieval-augmented generation (RAG) based on Knowledge Graphs (KGs) to improve the accuracy and reliability of Large Language Models (LLMs). Recent approaches suffer from insufficient and repetitive knowledge retrieval, tedious and time-consuming query parsing, and monotonous knowledge utilization. To this end, we develop a Hypothesis Knowledge Graph Enhanced (HyKGE) framework, which leverages LLMs' powerful reasoning capacity to compensate for the incompleteness of user queries, optimizes the interaction process with LLMs, and provides diverse retrieved knowledge. Specifically, HyKGE explores the zero-shot capability and the rich knowledge of LLMs with Hypothesis Outputs to extend feasible exploration directions in the KGs, as well as the carefully curated prompt to enhance the density and efficiency of LLMs' responses. Furthermore, we introduce the HO Fragment Granularity-aware Rerank Module to filter out noise while ensuring the balance between diversity and relevance in retrieved knowledge. Experiments on two Chinese medical multiple-choice question datasets and one Chinese open-domain medical Q&A dataset with two LLM turbos demonstrate the superiority of HyKGE in terms of accuracy and explainability.

Yongxin Xu, Ruizhe Zhang, Xinke Jiang et al.

Retrieval-Augmented Generation (RAG) offers an effective solution to the issues faced by Large Language Models (LLMs) in hallucination generation and knowledge obsolescence by incorporating externally retrieved knowledge. However, existing methods lack effective control mechanisms for integrating internal and external knowledge. Inspired by human cognitive processes, we propose Parenting, a novel framework that decouples, identifies, and purposefully optimizes parameter subspaces related to adherence and robustness. Specifically, Parenting utilizes a key parameter mining method that combines forward and backward propagation signals to localize subspaces representing different capabilities. Then, Parenting employs a type-tailored tuning strategy, applying specific and appropriate optimizations to different subspaces, aiming to achieve a balanced enhancement of both adherence and robustness. Extensive experiments on various datasets and models validate the effectiveness and generalizability of our method.

Hongxin Ding, Baixiang Huang, Yue Fang et al.

Interactive medical questioning is essential in real-world clinical consultations, where physicians must actively gather information from patients. While medical Large Language Models (LLMs) have shown impressive capabilities in static medical question answering, they predominantly operate under a reactive paradigm: generating answers directly without seeking additional information, which risks incorrect diagnoses in such interactive settings. To address this limitation, we propose ProMed, a reinforcement learning (RL) framework that transitions medical LLMs toward a proactive paradigm, equipping them with the ability to ask clinically valuable questions before decision-making. At the core of ProMed is the Shapley Information Gain (SIG) reward, which quantifies the clinical utility of each question by combining the amount of newly acquired information with its contextual importance, estimated via Shapley values. We integrate SIG into a two-stage training pipeline: (1) SIG-Guided Model Initialization uses Monte Carlo Tree Search (MCTS) to construct high-reward interaction trajectories to supervise the model, and (2) SIG-Augmented Policy Optimization, which integrates SIG and enhances RL with a novel SIG-guided Reward Distribution Mechanism that assigns higher rewards to informative questions for targeted optimization. Extensive experiments on two newly curated partial-information medical benchmarks demonstrate that ProMed significantly outperforms state-of-the-art methods by an average of 6.29% and delivers a 54.45% gain over the reactive paradigm, while also generalizing robustly to out-of-domain cases.