Bingo Wing-Kuen Ling

Mengran Li, Bo Li, Jiaying Wang et al.

Virtual Cell Modeling (VCM) requires models that not only predict perturbation responses, but also support targeted revision when predictions fail. Current LLM-assisted modeling workflows face a refinement-routing problem: prediction discrepancies are observed through executable implementations, but the relevant revision may involve the modeling assumption, representation design, implementation, or task constraint. Without structured feedback propagation across these levels, iterative refinement may repair code while failing to revise the assumption responsible for the discrepancy. We propose CellScientist, a dual-space hierarchical framework that couples a high-level hypothesis space with a low-level executable implementation space. CellScientist represents modeling decisions as structured states, realizes them as admissible programs under task and interface constraints, and routes execution discrepancies back to targeted hypothesis or implementation updates. This enables a closed Hypothesis -> Implementation -> Hypothesis loop where failures become structured signals for model refinement rather than debugging events. Across morphology and transcriptomic benchmarks, with additional single-cell perturbation evaluations, the final executable models selected by CellScientist improve over reference baselines under fixed split and evaluation protocols, while the workflow produces auditable refinement traces.

Yiting Wei, Bingo Wing-Kuen Ling, Qing Liu et al.

Diabetes is a serious chronic metabolic disease. In the recent years, more and more consumer technology enterprises focusing on human health are committed to implementing accurate and non-invasive blood glucose algorithm in their products. However, due to the interference from the external environment, these wearable non-invasive methods yield the low estimation accuracy. To address this issue, this paper employs different models based on different ranges of the blood glucose values for performing the blood glucose estimation. First the photoplethysmograms (PPGs) are acquired and they are denoised via the bit plane singular spectrum analysis (SSA) method. Second, the features are extracted. For the data in the training set, first the features are averaged across the measurements in the feature domain via the optimization approach. Second, the random forest is employed to sort the importance of each feature. Third, the training set is divided into three subsets according to the reference blood glucose values. Fourth, the feature vectors and the corresponding blood glucose values in the same group are employed to build an individual model. Fifth, for each feature, the average of the feature values for all the measurements in the same subset is computed. For the data in the test set, first, the sum of the weighted distances between the test feature values and the average values obtained in the above is computed for each model. Here, the weights are defined based on the importance sorted by the random forest obtained in the above. The model corresponding to the smallest sum is assigned. Finally, the blood glucose value is estimated based on the corresponding model. Compared to the state of arts methods, our proposed method can effectively improve the estimation accuracy.

Yiting Wei, Bingo Wing-Kuen Ling, Danni Chen et al.

Recently, the wearable and non-invasive blood glucose estimation approach has been proposed. However, due to the unreliability of the acquisition device, the presence of the noise and the variations of the acquisition environments, the obtained features and the reference blood glucose values are highly unreliable. To address this issue, this paper proposes a polynomial fitting approach to smooth the obtained features or the reference blood glucose values. First, the blood glucose values are estimated based on the individual optimization approaches. Second, the absolute difference values between the estimated blood glucose values and the actual blood glucose values based on each optimization approach are computed. Third, these absolute difference values for each optimization approach are sorted in the ascending order. Fourth, for each sorted blood glucose value, the optimization method corresponding to the minimum absolute difference value is selected. Fifth, the accumulate probability of each selected optimization method is computed. If the accumulate probability of any selected optimization method at a point is greater than a threshold value, then the accumulate probabilities of these three selected optimization methods at that point are reset to zero. A range of the sorted blood glucose values are defined as that with the corresponding boundaries points being the previous reset point and this reset point. Hence, after performing the above procedures for all the sorted reference blood glucose values in the validation set, the regions of the sorted reference blood glucose values and the corresponding optimization methods in these regions are determined. The computer numerical simulation results show that our proposed method yields the mean absolute relative deviation (MARD) at 0.0930 and the percentage of the test data falling in the zone A of the Clarke error grid at 94.1176%.

FangYuan Lei, Xun Liu, QingYun Dai et al.

With higher-order neighborhood information of graph network, the accuracy of graph representation learning classification can be significantly improved. However, the current higher order graph convolutional network has a large number of parameters and high computational complexity. Therefore, we propose a Hybrid Lower order and Higher order Graph convolutional networks (HLHG) learning model, which uses weight sharing mechanism to reduce the number of network parameters. To reduce computational complexity, we propose a novel fusion pooling layer to combine the neighborhood information of high order and low order. Theoretically, we compare the model complexity of the proposed model with the other state-of-the-art model. Experimentally, we verify the proposed model on the large-scale text network datasets by supervised learning, and on the citation network datasets by semi-supervised learning. The experimental results show that the proposed model achieves highest classification accuracy with a small set of trainable weight parameters.