Wenjun Liao

Jia Fu, Litingyu Wang, He Li et al.

Accurate delineation of Gross Tumor Volume (GTV), Lymph Node Clinical Target Volume (LN CTV), and Organ-at-Risk (OAR) from Computed Tomography (CT) scans is essential for precise radiotherapy planning in Nasopharyngeal Carcinoma (NPC). Building upon SegRap2023, which focused on OAR and GTV segmentation using single-center paired non-contrast CT (ncCT) and contrast-enhanced CT (ceCT) scans, the SegRap2025 challenge aims to enhance the generalizability and robustness of segmentation models across imaging centers and modalities. SegRap2025 comprises two tasks: Task01 addresses GTV segmentation using paired CT from the SegRap2023 dataset, with an additional external testing set to evaluate cross-center generalization, and Task02 focuses on LN CTV segmentation using multi-center training data and an unseen external testing set, where each case contains paired CT scans or a single modality, emphasizing both cross-center and cross-modality robustness. This paper presents the challenge setup and provides a comprehensive analysis of the solutions submitted by ten participating teams. For GTV segmentation task, the top-performing models achieved average Dice Similarity Coefficient (DSC) of 74.61% and 56.79% on the internal and external testing cohorts, respectively. For LN CTV segmentation task, the highest average DSC values reached 60.24%, 60.50%, and 57.23% on paired CT, ceCT-only, and ncCT-only subsets, respectively. SegRap2025 establishes a large-scale multi-center, multi-modality benchmark for evaluating the generalization and robustness in radiotherapy target segmentation, providing valuable insights toward clinically applicable automated radiotherapy planning systems. The benchmark is available at: https://hilab-git.github.io/SegRap2025_Challenge.

Zihao Luo, Zijun Gao, Wenjun Liao et al.

Accurate lymph node (LN) segmentation is critical in radiotherapy treatment and prognosis analysis, but is limited by the need for large annotated datasets. While deep learning-based segmentation foundation models show potential in developing high-performing models with fewer samples, their medical adaptation faces LN domain-specific prior deficiencies and inefficient few-shot fine-tuning for complex clinical practices, highlighting the necessity of an LN segmentation foundation model. In this work, we annotated 36,106 visible LNs from 3,346 publicly available head-and-neck CT scans to establish a robust LN segmentation model (nnUNetv2). Building on this, we propose Dynamic Gradient Sparsification Training (DGST), a few-shot fine-tuning approach that preserves foundational knowledge while dynamically updating the most critical parameters of the LN segmentation model with few annotations. We validate it on two publicly available LN segmentation datasets: SegRap2023 and LNQ2023. The results show that DGST outperforms existing few-shot fine-tuning methods, achieving satisfactory performance with limited labeled data. We release the dataset, models and all implementations to facilitate relevant research: https://github.com/Zihaoluoh/LN-Seg-FM.

Xiaochuan Ma, Jia Fu, Wenjun Liao et al.

Brain tumor segmentation is important for diagnosis of the tumor, and current deep-learning methods rely on a large set of annotated images for training, with high annotation costs. Unsupervised segmentation is promising to avoid human annotations while the performance is often limited. In this study, we present a novel unsupervised segmentation approach that leverages the capabilities of foundation models, and it consists of three main steps: (1) A vision-language model (i.e., CLIP) is employed to obtain image-level pseudo-labels for training a classification network. Class Activation Mapping (CAM) is then employed to extract Regions of Interest (ROIs), where an adaptive masking-based data augmentation is used to enhance ROI identification.(2) The ROIs are used to generate bounding box and point prompts for the Segment Anything Model (SAM) to obtain segmentation pseudo-labels. (3) A 3D segmentation network is trained with the SAM-derived pseudo-labels, where low-quality pseudo-labels are filtered out in a self-learning process based on the similarity between the SAM's output and the network's prediction. Evaluation on the BraTS2020 dataset demonstrates that our approach obtained an average Dice Similarity Score (DSC) of 85.60%, outperforming five state-of-the-art unsupervised segmentation methods by more than 10 percentage points. Besides, our approach outperforms directly using SAM for zero-shot inference, and its performance is close to fully supervised learning.