29.6CLDec 23, 2025
Nemotron 3 Nano: Open, Efficient Mixture-of-Experts Hybrid Mamba-Transformer Model for Agentic ReasoningAaron Blakeman, Aaron Grattafiori, Aarti Basant et al. · nvidia
We present Nemotron 3 Nano 30B-A3B, a Mixture-of-Experts hybrid Mamba-Transformer language model. Nemotron 3 Nano was pretrained on 25 trillion text tokens, including more than 3 trillion new unique tokens over Nemotron 2, followed by supervised fine tuning and large-scale RL on diverse environments. Nemotron 3 Nano achieves better accuracy than our previous generation Nemotron 2 Nano while activating less than half of the parameters per forward pass. It achieves up to 3.3x higher inference throughput than similarly-sized open models like GPT-OSS-20B and Qwen3-30B-A3B-Thinking-2507, while also being more accurate on popular benchmarks. Nemotron 3 Nano demonstrates enhanced agentic, reasoning, and chat abilities and supports context lengths up to 1M tokens. We release both our pretrained Nemotron 3 Nano 30B-A3B Base and post-trained Nemotron 3 Nano 30B-A3B checkpoints on Hugging Face.
Heterogenous Ensemble of Models for Molecular Property PredictionSajad Darabi, Shayan Fazeli, Jiwei Liu et al.
Previous works have demonstrated the importance of considering different modalities on molecules, each of which provide a varied granularity of information for downstream property prediction tasks. Our method combines variants of the recent TransformerM architecture with Transformer, GNN, and ResNet backbone architectures. Models are trained on the 2D data, 3D data, and image modalities of molecular graphs. We ensemble these models with a HuberRegressor. The models are trained on 4 different train/validation splits of the original train + valid datasets. This yields a winning solution to the 2\textsuperscript{nd} edition of the OGB Large-Scale Challenge (2022) on the PCQM4Mv2 molecular property prediction dataset. Our proposed method achieves a test-challenge MAE of $0.0723$ and a validation MAE of $0.07145$. Total inference time for our solution is less than 2 hours. We open-source our code at https://github.com/jfpuget/NVIDIA-PCQM4Mv2.
Optimized U-Net for Brain Tumor SegmentationMichał Futrega, Alexandre Milesi, Michal Marcinkiewicz et al.
We propose an optimized U-Net architecture for a brain tumor segmentation task in the BraTS21 challenge. To find the optimal model architecture and the learning schedule, we have run an extensive ablation study to test: deep supervision loss, Focal loss, decoder attention, drop block, and residual connections. Additionally, we have searched for the optimal depth of the U-Net encoder, number of convolutional channels and post-processing strategy. Our method won the validation phase and took third place in the test phase. We have open-sourced the code to reproduce our BraTS21 submission at the NVIDIA Deep Learning Examples GitHub Repository.