Kechun Liu

Kechun Liu, Wenjun Wu, Joann G. Elmore et al.

Accurate cancer diagnosis remains a critical challenge in digital pathology, largely due to the gigapixel size and complex spatial relationships present in whole slide images. Traditional multiple instance learning (MIL) methods often struggle with these intricacies, especially in preserving the necessary context for accurate diagnosis. In response, we introduce a novel framework named Semantics-Aware Attention Guidance (SAG), which includes 1) a technique for converting diagnostically relevant entities into attention signals, and 2) a flexible attention loss that efficiently integrates various semantically significant information, such as tissue anatomy and cancerous regions. Our experiments on two distinct cancer datasets demonstrate consistent improvements in accuracy, precision, and recall with two state-of-the-art baseline models. Qualitative analysis further reveals that the incorporation of heuristic guidance enables the model to focus on regions critical for diagnosis. SAG is not only effective for the models discussed here, but its adaptability extends to any attention-based diagnostic model. This opens up exciting possibilities for further improving the accuracy and efficiency of cancer diagnostics.

Zefang Zong, Jie Feng, Kechun Liu et al.

Dynamic high resolution data on human population distribution is of great importance for a wide spectrum of activities and real-life applications, but is too difficult and expensive to obtain directly. Therefore, generating fine-scaled population distributions from coarse population data is of great significance. However, there are three major challenges: 1) the complexity in spatial relations between high and low resolution population; 2) the dependence of population distributions on other external information; 3) the difficulty in retrieving temporal distribution patterns. In this paper, we first propose the idea to generate dynamic population distributions in full-time series, then we design dynamic population mapping via deep neural network(DeepDPM), a model that describes both spatial and temporal patterns using coarse data and point of interest information. In DeepDPM, we utilize super-resolution convolutional neural network(SRCNN) based model to directly map coarse data into higher resolution data, and a time-embedded long short-term memory model to effectively capture the periodicity nature to smooth the finer-scaled results from the previous static SRCNN model. We perform extensive experiments on a real-life mobile dataset collected from Shanghai. Our results demonstrate that DeepDPM outperforms previous state-of-the-art methods and a suite of frequent data-mining approaches. Moreover, DeepDPM breaks through the limitation from previous works in time dimension so that dynamic predictions in all-day time slots can be obtained.