Mahyar Abbasian

Mahyar Abbasian, Iman Azimi, Amir M. Rahmani et al.

Conversational Health Agents (CHAs) are interactive systems that provide healthcare services, such as assistance and diagnosis. Current CHAs, especially those utilizing Large Language Models (LLMs), primarily focus on conversation aspects. However, they offer limited agent capabilities, specifically lacking multi-step problem-solving, personalized conversations, and multimodal data analysis. Our aim is to overcome these limitations. We propose openCHA, an open-source LLM-powered framework, to empower conversational agents to generate a personalized response for users' healthcare queries. This framework enables developers to integrate external sources including data sources, knowledge bases, and analysis models, into their LLM-based solutions. openCHA includes an orchestrator to plan and execute actions for gathering information from external sources, essential for formulating responses to user inquiries. It facilitates knowledge acquisition, problem-solving capabilities, multilingual and multimodal conversations, and fosters interaction with various AI platforms. We illustrate the framework's proficiency in handling complex healthcare tasks via two demonstrations and four use cases. Moreover, we release openCHA as open source available to the community via GitHub.

Mahyar Abbasian, Elahe Khatibi, Iman Azimi et al.

Generative Artificial Intelligence is set to revolutionize healthcare delivery by transforming traditional patient care into a more personalized, efficient, and proactive process. Chatbots, serving as interactive conversational models, will probably drive this patient-centered transformation in healthcare. Through the provision of various services, including diagnosis, personalized lifestyle recommendations, and mental health support, the objective is to substantially augment patient health outcomes, all the while mitigating the workload burden on healthcare providers. The life-critical nature of healthcare applications necessitates establishing a unified and comprehensive set of evaluation metrics for conversational models. Existing evaluation metrics proposed for various generic large language models (LLMs) demonstrate a lack of comprehension regarding medical and health concepts and their significance in promoting patients' well-being. Moreover, these metrics neglect pivotal user-centered aspects, including trust-building, ethics, personalization, empathy, user comprehension, and emotional support. The purpose of this paper is to explore state-of-the-art LLM-based evaluation metrics that are specifically applicable to the assessment of interactive conversational models in healthcare. Subsequently, we present an comprehensive set of evaluation metrics designed to thoroughly assess the performance of healthcare chatbots from an end-user perspective. These metrics encompass an evaluation of language processing abilities, impact on real-world clinical tasks, and effectiveness in user-interactive conversations. Finally, we engage in a discussion concerning the challenges associated with defining and implementing these metrics, with particular emphasis on confounding factors such as the target audience, evaluation methods, and prompt techniques involved in the evaluation process.

Jung In Park, Mahyar Abbasian, Iman Azimi et al.

Objective: This study aims to develop and validate an evaluation framework to ensure the safety and reliability of mental health chatbots, which are increasingly popular due to their accessibility, human-like interactions, and context-aware support. Materials and Methods: We created an evaluation framework with 100 benchmark questions and ideal responses, and five guideline questions for chatbot responses. This framework, validated by mental health experts, was tested on a GPT-3.5-turbo-based chatbot. Automated evaluation methods explored included large language model (LLM)-based scoring, an agentic approach using real-time data, and embedding models to compare chatbot responses against ground truth standards. Results: The results highlight the importance of guidelines and ground truth for improving LLM evaluation accuracy. The agentic method, dynamically accessing reliable information, demonstrated the best alignment with human assessments. Adherence to a standardized, expert-validated framework significantly enhanced chatbot response safety and reliability. Discussion: Our findings emphasize the need for comprehensive, expert-tailored safety evaluation metrics for mental health chatbots. While LLMs have significant potential, careful implementation is necessary to mitigate risks. The superior performance of the agentic approach underscores the importance of real-time data access in enhancing chatbot reliability. Conclusion: The study validated an evaluation framework for mental health chatbots, proving its effectiveness in improving safety and reliability. Future work should extend evaluations to accuracy, bias, empathy, and privacy to ensure holistic assessment and responsible integration into healthcare. Standardized evaluations will build trust among users and professionals, facilitating broader adoption and improved mental health support through technology.

Mahyar Abbasian, Taha Rajabzadeh, Ahmadreza Moradipari et al.

Generative Adversarial Networks (GAN) have emerged as a formidable AI tool to generate realistic outputs based on training datasets. However, the challenge of exerting control over the generation process of GANs remains a significant hurdle. In this paper, we propose a novel methodology to address this issue by integrating a reinforcement learning (RL) agent with a latent-space GAN (l-GAN), thereby facilitating the generation of desired outputs. More specifically, we have developed an actor-critic RL agent with a meticulously designed reward policy, enabling it to acquire proficiency in navigating the latent space of the l-GAN and generating outputs based on specified tasks. To substantiate the efficacy of our approach, we have conducted a series of experiments employing the MNIST dataset, including arithmetic addition as an illustrative task. The outcomes of these experiments serve to validate our methodology. Our pioneering integration of an RL agent with a GAN model represents a novel advancement, holding great potential for enhancing generative networks in the future.

Mahyar Abbasian, Zhongqi Yang, Elahe Khatibi et al.

Effective diabetes management is crucial for maintaining health in diabetic patients. Large Language Models (LLMs) have opened new avenues for diabetes management, facilitating their efficacy. However, current LLM-based approaches are limited by their dependence on general sources and lack of integration with domain-specific knowledge, leading to inaccurate responses. In this paper, we propose a knowledge-infused LLM-powered conversational health agent (CHA) for diabetic patients. We customize and leverage the open-source openCHA framework, enhancing our CHA with external knowledge and analytical capabilities. This integration involves two key components: 1) incorporating the American Diabetes Association dietary guidelines and the Nutritionix information and 2) deploying analytical tools that enable nutritional intake calculation and comparison with the guidelines. We compare the proposed CHA with GPT4. Our evaluation includes 100 diabetes-related questions on daily meal choices and assessing the potential risks associated with the suggested diet. Our findings show that the proposed agent demonstrates superior performance in generating responses to manage essential nutrients.

Zhongqi Yang, Elahe Khatibi, Nitish Nagesh et al.

The profound impact of food on health necessitates advanced nutrition-oriented food recommendation services. Conventional methods often lack the crucial elements of personalization, explainability, and interactivity. While Large Language Models (LLMs) bring interpretability and explainability, their standalone use falls short of achieving true personalization. In this paper, we introduce ChatDiet, a novel LLM-powered framework designed specifically for personalized nutrition-oriented food recommendation chatbots. ChatDiet integrates personal and population models, complemented by an orchestrator, to seamlessly retrieve and process pertinent information. The personal model leverages causal discovery and inference techniques to assess personalized nutritional effects for a specific user, whereas the population model provides generalized information on food nutritional content. The orchestrator retrieves, synergizes and delivers the output of both models to the LLM, providing tailored food recommendations designed to support targeted health outcomes. The result is a dynamic delivery of personalized and explainable food recommendations, tailored to individual user preferences. Our evaluation of ChatDiet includes a compelling case study, where we establish a causal personal model to estimate individual nutrition effects. Our assessments, including a food recommendation test showcasing a 92\% effectiveness rate, coupled with illustrative dialogue examples, underscore ChatDiet's strengths in explainability, personalization, and interactivity.

Elahe Khatibi, Mahyar Abbasian, Zhongqi Yang et al.

To perform effective causal inference in high-dimensional datasets, initiating the process with causal discovery is imperative, wherein a causal graph is generated based on observational data. However, obtaining a complete and accurate causal graph poses a formidable challenge, recognized as an NP- hard problem. Recently, the advent of Large Language Models (LLMs) has ushered in a new era, indicating their emergent capabilities and widespread applicability in facilitating causal reasoning across diverse domains, such as medicine, finance, and science. The expansive knowledge base of LLMs holds the potential to elevate the field of causal reasoning by offering interpretability, making inferences, generalizability, and uncovering novel causal structures. In this paper, we introduce a new framework, named Autonomous LLM-Augmented Causal Discovery Framework (ALCM), to synergize data-driven causal discovery algorithms and LLMs, automating the generation of a more resilient, accurate, and explicable causal graph. The ALCM consists of three integral components: causal structure learning, causal wrapper, and LLM-driven causal refiner. These components autonomously collaborate within a dynamic environment to address causal discovery questions and deliver plausible causal graphs. We evaluate the ALCM framework by implementing two demonstrations on seven well-known datasets. Experimental results demonstrate that ALCM outperforms existing LLM methods and conventional data-driven causal reasoning mechanisms. This study not only shows the effectiveness of the ALCM but also underscores new research directions in leveraging the causal reasoning capabilities of LLMs.

Mahyar Abbasian, Iman Azimi, Mohammad Feli et al.

Agents represent one of the most emerging applications of Large Language Models (LLMs) and Generative AI, with their effectiveness hinging on multimodal capabilities to navigate complex user environments. Conversational Health Agents (CHAs), a prime example of this, are redefining healthcare by offering nuanced support that transcends textual analysis to incorporate emotional intelligence. This paper introduces an LLM-based CHA engineered for rich, multimodal dialogue-especially in the realm of mental health support. It adeptly interprets and responds to users' emotional states by analyzing multimodal cues, thus delivering contextually aware and empathetically resonant verbal responses. Our implementation leverages the versatile openCHA framework, and our comprehensive evaluation involves neutral prompts expressed in diverse emotional tones: sadness, anger, and joy. We evaluate the consistency and repeatability of the planning capability of the proposed CHA. Furthermore, human evaluators critique the CHA's empathic delivery, with findings revealing a striking concordance between the CHA's outputs and evaluators' assessments. These results affirm the indispensable role of vocal (soon multimodal) emotion recognition in strengthening the empathetic connection built by CHAs, cementing their place at the forefront of interactive, compassionate digital health solutions.

Zhenyu Lu, Mahyar Abbasian, Amir M. Rahmani

Large language models (LLMs) are increasingly applied to analyzing wearable sensing data, which are long-term, multimodal, and highly personalized. A key challenge is context selection: providing insufficient context limits reasoning, while including all available data leads to inefficiency and degraded generation quality. We propose Wearable As Graph (WAG), a graph-based context retrieval framework that enables query-adaptive reasoning over wearable data with LLMs. WAG organizes wearable metrics and user-specific signals into a personalized knowledge graph, and retrieves a query-conditioned subgraph to support downstream generation. The retrieval process integrates global relationships, capturing prior knowledge and population- and individual-level patterns via hierarchical Bayesian modeling, with local relationships that reflect short-term signal deviations. A query openness signal further controls retrieval breadth. We evaluate WAG on over 10,000 data-grounded queries from real-world wearable datasets. Across LLM-based and human evaluations, WAG achieves an approximately 70% win rate over baseline and standard RAG methods, demonstrating the effectiveness of structured, query-adaptive context retrieval for LLM-driven analysis of wearable data.

Mahyar Abbasian, Ramesh Jain

Building on decades of success in digital infrastructure and biomedical innovation, we propose the Personal Care Utility (PCU) - a cybernetic system for lifelong health guidance. PCU is conceived as a global, AI-powered utility that continuously orchestrates multimodal data, knowledge, and services to assist individuals and populations alike. Drawing on multimodal agents, event-centric modeling, and contextual inference, it offers three essential capabilities: (1) trusted health information tailored to the individual, (2) proactive health navigation and behavior guidance, and (3) ongoing interpretation of recovery and treatment response after medical events. Unlike conventional episodic care, PCU functions as an ambient, adaptive companion - observing, interpreting, and guiding health in real time across daily life. By integrating personal sensing, experiential computing, and population-level analytics, PCU promises not only improved outcomes for individuals but also a new substrate for public health and scientific discovery. We describe the architecture, design principles, and implementation challenges of this emerging paradigm.