AIMar 2
HarmonyCell: Automating Single-Cell Perturbation Modeling under Semantic and Distribution ShiftsWenxuan Huang, Mingyu Tsoi, Yanhao Huang et al.
Single-cell perturbation studies face dual heterogeneity bottlenecks: (i) semantic heterogeneity--identical biological concepts encoded under incompatible metadata schemas across datasets; and (ii) statistical heterogeneity--distribution shifts from biological variation demanding dataset-specific inductive biases. We propose HarmonyCell, an end-to-end agent framework resolving each challenge through a dedicated mechanism: an LLM-driven Semantic Unifier autonomously maps disparate metadata into a canonical interface without manual intervention; and an adaptive Monte Carlo Tree Search engine operates over a hierarchical action space to synthesize architectures with optimal statistical inductive biases for distribution shifts. Evaluated across diverse perturbation tasks under both semantic and distribution shifts, HarmonyCell achieves a 95% valid execution rate on heterogeneous input datasets (versus 0% for general agents) while matching or even exceeding expert-designed baselines in rigorous out-of-distribution evaluations. This dual-track orchestration enables scalable automatic virtual cell modeling without dataset-specific engineering.
SPFeb 28, 2025
A novel Fourier Adjacency Transformer for advanced EEG emotion recognitionJinfeng Wang, Yanhao Huang, Sifan Song et al.
EEG emotion recognition faces significant hurdles due to noise interference, signal nonstationarity, and the inherent complexity of brain activity which make accurately emotion classification. In this study, we present the Fourier Adjacency Transformer, a novel framework that seamlessly integrates Fourier-based periodic analysis with graph-driven structural modeling. Our method first leverages novel Fourier-inspired modules to extract periodic features from embedded EEG signals, effectively decoupling them from aperiodic components. Subsequently, we employ an adjacency attention scheme to reinforce universal inter-channel correlation patterns, coupling these patterns with their sample-based counterparts. Empirical evaluations on SEED and DEAP datasets demonstrate that our method surpasses existing state-of-the-art techniques, achieving an improvement of approximately 6.5% in recognition accuracy. By unifying periodicity and structural insights, this framework offers a promising direction for future research in EEG emotion analysis.
LGMay 22, 2019
An Interactive Insight Identification and Annotation Framework for Power Grid Pixel Maps using DenseU-Hierarchical VAETianye Zhang, Haozhe Feng, Zexian Chen et al.
Insights in power grid pixel maps (PGPMs) refer to important facility operating states and unexpected changes in the power grid. Identifying insights helps analysts understand the collaboration of various parts of the grid so that preventive and correct operations can be taken to avoid potential accidents. Existing solutions for identifying insights in PGPMs are performed manually, which may be laborious and expertise-dependent. In this paper, we propose an interactive insight identification and annotation framework by leveraging an enhanced variational autoencoder (VAE). In particular, a new architecture, DenseU-Hierarchical VAE (DUHiV), is designed to learn representations from large-sized PGPMs, which achieves a significantly tighter evidence lower bound (ELBO) than existing Hierarchical VAEs with a Multilayer Perceptron architecture. Our approach supports modulating the derived representations in an interactive visual interface, discover potential insights and create multi-label annotations. Evaluations using real-world PGPMs datasets show that our framework outperforms the baseline models in identifying and annotating insights.
LGMay 17, 2018
Deep-learning Based Modeling of Fault Detachment Stability for Power GridHaotian Cui, Xianggen Liu, Yanhao Huang
The project intends to model the stability of power system with a deep learning algorithm to the problem, aiming to delay the removal of the fault. The so-called "fail-delay cut-off" refers to the occurrence of N-1 backup protection action on the backbone network of the system, resulting in longer time for the removal of the fault. In practice, through the analysis and calculation of a large number of online data, we have found that the N-1 failure system of the main protection action will not be unstable, which is also a guarantee of the operation mode arrangement. In the case of the N-1 backup protection action, there is an approximately 2.5% probability that the system will be destabilized. Therefore, research is needed to improve the operating arrangement.