Haozheng Zhang

Haozheng Zhang, Edmond S. L. Ho, Xiatian Zhang et al.

Parkinson's disease (PD) is a progressive neurodegenerative disorder that results in a variety of motor dysfunction symptoms, including tremors, bradykinesia, rigidity and postural instability. The diagnosis of PD mainly relies on clinical experience rather than a definite medical test, and the diagnostic accuracy is only about 73-84% since it is challenged by the subjective opinions or experiences of different medical experts. Therefore, an efficient and interpretable automatic PD diagnosis system is valuable for supporting clinicians with more robust diagnostic decision-making. To this end, we propose to classify Parkinson's tremor since it is one of the most predominant symptoms of PD with strong generalizability. Different from other computer-aided time and resource-consuming Parkinson's Tremor (PT) classification systems that rely on wearable sensors, we propose SPAPNet, which only requires consumer-grade non-intrusive video recording of camera-facing human movements as input to provide undiagnosed patients with low-cost PT classification results as a PD warning sign. For the first time, we propose to use a novel attention module with a lightweight pyramidal channel-squeezing-fusion architecture to extract relevant PT information and filter the noise efficiently. This design aids in improving both classification performance and system interpretability. Experimental results show that our system outperforms state-of-the-arts by achieving a balanced accuracy of 90.9% and an F1-score of 90.6% in classifying PT with the non-PT class.

Haozheng Zhang, Hubert P. H. Shum, Edmond S. L. Ho

Early diagnosis and intervention are clinically considered the paramount part of treating cerebral palsy (CP), so it is essential to design an efficient and interpretable automatic prediction system for CP. We highlight a significant difference between CP infants' frequency of human movement and that of the healthy group, which improves prediction performance. However, the existing deep learning-based methods did not use the frequency information of infants' movement for CP prediction. This paper proposes a frequency attention informed graph convolutional network and validates it on two consumer-grade RGB video datasets, namely MINI-RGBD and RVI-38 datasets. Our proposed frequency attention module aids in improving both classification performance and system interpretability. In addition, we design a frequency-binning method that retains the critical frequency of the human joint position data while filtering the noise. Our prediction performance achieves state-of-the-art research on both datasets. Our work demonstrates the effectiveness of frequency information in supporting the prediction of CP non-intrusively and provides a way for supporting the early diagnosis of CP in the resource-limited regions where the clinical resources are not abundant.

Haozheng Zhang, Edmond S. L. Ho, Hubert P. H. Shum

Early prediction is clinically considered one of the essential parts of cerebral palsy (CP) treatment. We propose to implement a low-cost and interpretable classification system for supporting CP prediction based on General Movement Assessment (GMA). We design a Pytorch-based attention-informed graph convolutional network to early identify infants at risk of CP from skeletal data extracted from RGB videos. We also design a frequency-binning module for learning the CP movements in the frequency domain while filtering noise. Our system only requires consumer-grade RGB videos for training to support interactive-time CP prediction by providing an interpretable CP classification result.

Xiatian Zhang, Sisi Zheng, Hubert P. H. Shum et al.

Resting-state fMRI (rs-fMRI) functional connectivity (FC) analysis provides valuable insights into the relationships between different brain regions and their potential implications for neurological or psychiatric disorders. However, specific design efforts to predict treatment response from rs-fMRI remain limited due to difficulties in understanding the current brain state and the underlying mechanisms driving the observed patterns, which limited the clinical application of rs-fMRI. To overcome that, we propose a graph learning framework that captures comprehensive features by integrating both correlation and distance-based similarity measures under a contrastive loss. This approach results in a more expressive framework that captures brain dynamic features at different scales and enables more accurate prediction of treatment response. Our experiments on the chronic pain and depersonalization disorder datasets demonstrate that our proposed method outperforms current methods in different scenarios. To the best of our knowledge, we are the first to explore the integration of distance-based and correlation-based neural similarity into graph learning for treatment response prediction.

Haozheng Zhang, Edmond S. L. Ho, Xiatian Zhang et al.

Purpose:Current methods for diagnosis of PD rely on clinical examination. The accuracy of diagnosis ranges between 73% and 84%, and is influenced by the experience of the clinical assessor. Hence, an automatic, effective and interpretable supporting system for PD symptom identification would support clinicians in making more robust PD diagnostic decisions. Methods: We propose to analyze Parkinson's tremor (PT) to support the analysis of PD, since PT is one of the most typical symptoms of PD with broad generalizability. To realize the idea, we present SPA-PTA, a deep learning-based PT classification and severity estimation system that takes consumer-grade videos of front-facing humans as input. The core of the system is a novel attention module with a lightweight pyramidal channel-squeezing-fusion architecture that effectively extracts relevant PT information and filters noise. It enhances modeling performance while improving system interpretability. Results:We validate our system via individual-based leave-one-out cross-validation on two tasks: the PT classification task and the tremor severity rating estimation task. Our system presents a 91.3% accuracy and 80.0% F1-score in classifying PT with non-PT class, while providing a 76.4% accuracy and 76.7% F1-score in more complex multiclass tremor rating classification task. Conclusion: Our system offers a cost-effective PT classification and tremor severity estimation results as warning signs of PD for undiagnosed patients with PT symptoms. In addition, it provides a potential solution for supporting PD diagnosis in regions with limited clinical resources.