Sheng Xu

Zhiming Wang, Mingze Wang, Sheng Xu et al.

Remote Sensing Image Change Captioning (RSICC) aims to generate natural language descriptions of surface changes between multi-temporal remote sensing images, detailing the categories, locations, and dynamics of changed objects (e.g., additions or disappearances). Many current methods attempt to leverage the long-sequence understanding and reasoning capabilities of multimodal large language models (MLLMs) for this task. However, without comprehensive data support, these approaches often alter the essential feature transmission pathways of MLLMs, disrupting the intrinsic knowledge within the models and limiting their potential in RSICC. In this paper, we propose a novel model, CCExpert, based on a new, advanced multimodal large model framework. Firstly, we design a difference-aware integration module to capture multi-scale differences between bi-temporal images and incorporate them into the original image context, thereby enhancing the signal-to-noise ratio of differential features. Secondly, we constructed a high-quality, diversified dataset called CC-Foundation, containing 200,000 image pairs and 1.2 million captions, to provide substantial data support for continue pretraining in this domain. Lastly, we employed a three-stage progressive training process to ensure the deep integration of the difference-aware integration module with the pretrained MLLM. CCExpert achieved a notable performance of $S^*_m=81.80$ on the LEVIR-CC benchmark, significantly surpassing previous state-of-the-art methods. The code and part of the dataset will soon be open-sourced at https://github.com/Meize0729/CCExpert.

Joe Kileel, Oscar Mickelin, Amit Singer et al.

Cryo-electron microscopy (cryo-EM) is a powerful imaging technique for reconstructing three-dimensional molecular structures from noisy tomographic projection images of randomly oriented particles. We introduce a new data fusion framework, termed the method of double moments (MoDM), which reconstructs molecular structures from two instances of the second-order moment of projection images obtained under distinct orientation distributions--one uniform, the other non-uniform and unknown. We prove that these moments generically uniquely determine the underlying structure, up to a global rotation and reflection, and we develop a convex-relaxation-based algorithm that achieves accurate recovery using only second-order statistics. Our results demonstrate the advantage of collecting and modeling multiple datasets under different experimental conditions, illustrating that leveraging dataset diversity can substantially enhance reconstruction quality in computational imaging tasks.

Mingze Wang, Lili Su, Cilin Yan et al.

The intelligent interpretation of buildings plays a significant role in urban planning and management, macroeconomic analysis, population dynamics, etc. Remote sensing image building interpretation primarily encompasses building extraction and change detection. However, current methodologies often treat these two tasks as separate entities, thereby failing to leverage shared knowledge. Moreover, the complexity and diversity of remote sensing image scenes pose additional challenges, as most algorithms are designed to model individual small datasets, thus lacking cross-scene generalization. In this paper, we propose a comprehensive remote sensing image building understanding model, termed RSBuilding, developed from the perspective of the foundation model. RSBuilding is designed to enhance cross-scene generalization and task universality. Specifically, we extract image features based on the prior knowledge of the foundation model and devise a multi-level feature sampler to augment scale information. To unify task representation and integrate image spatiotemporal clues, we introduce a cross-attention decoder with task prompts. Addressing the current shortage of datasets that incorporate annotations for both tasks, we have developed a federated training strategy to facilitate smooth model convergence even when supervision for some tasks is missing, thereby bolstering the complementarity of different tasks. Our model was trained on a dataset comprising up to 245,000 images and validated on multiple building extraction and change detection datasets. The experimental results substantiate that RSBuilding can concurrently handle two structurally distinct tasks and exhibits robust zero-shot generalization capabilities.

Zhongyue Zhang, Jiahua Rao, Jie Zhong et al.

Most human proteins remain undrugged, over 96% of human proteins remain unexploited by approved therapeutics. While structure-based virtual screening promises to expand the druggable proteome, existing methods lack atomic-level precision and fail to predict binding fitness, limiting translational impact. We present AuroBind, a scalable virtual screening framework that fine-tunes a custom atomic-level structural model on million-scale chemogenomic data. AuroBind integrates direct preference optimization, self-distillation from high-confidence complexes, and a teacher-student acceleration strategy to jointly predict ligand-bound structures and binding fitness. The proposed models outperform state-of-the-art models on structural and functional benchmarks while enabling 100,000-fold faster screening across ultra-large compound libraries. In a prospective screen across ten disease-relevant targets, AuroBind achieved experimental hit rates of 7-69%, with top compounds reaching sub-nanomolar to picomolar potency. For the orphan GPCRs GPR151 and GPR160, AuroBind identified both agonists and antagonists with success rates of 16-30%, and functional assays confirmed GPR160 modulation in liver and prostate cancer models. AuroBind offers a generalizable framework for structure-function learning and high-throughput molecular screening, bridging the gap between structure prediction and therapeutic discovery.

Chenyang Fan, Xujie Zhu, Taige Luo et al.

The pattern analysis of tree structure holds significant scientific value for genetic breeding and forestry management. The current trunk and branch extraction technologies are mainly LiDAR-based or UAV-based. The former approaches obtain high-precision 3D data, but its equipment cost is high and the three-dimensional (3D) data processing is complex. The latter approaches efficiently capture canopy information, but they miss the 3-D structure of trees. In order to deal with the branch information extraction from the complex background interference and occlusion, this work proposes a novel WaveInst instance segmentation framework, involving a discrete wavelet transform, to enhance multi-scale edge information for accurately improving tree structure extraction. Experimental results of the proposed model show superior performance on SynthTree43k, CaneTree100, Urban Street and our PoplarDataset. Moreover, we present a new Phenotypic dataset PoplarDataset, which is dedicated to extract tree structure and pattern analysis from artificial forest. The proposed method achieves a mean average precision of 49.6 and 24.3 for the structure extraction of mature and juvenile trees, respectively, surpassing the existing state-of-the-art method by 9.9. Furthermore, by in tegrating the segmentation model within the regression model, we accurately achieve significant tree grown parameters, such as the location of trees, the diameter-at-breast-height of individual trees, and the plant height, from 2D images directly. This study provides a scientific and plenty of data for tree structure analysis in related to the phenotype research, offering a platform for the significant applications in precision forestry, ecological monitoring, and intelligent breeding.

Minghao Gou, Hao-Shu Fang, Zhanda Zhu et al.

General object grasping is an important yet unsolved problem in the field of robotics. Most of the current methods either generate grasp poses with few DoF that fail to cover most of the success grasps, or only take the unstable depth image or point cloud as input which may lead to poor results in some cases. In this paper, we propose RGBD-Grasp, a pipeline that solves this problem by decoupling 7-DoF grasp detection into two sub-tasks where RGB and depth information are processed separately. In the first stage, an encoder-decoder like convolutional neural network Angle-View Net(AVN) is proposed to predict the SO(3) orientation of the gripper at every location of the image. Consequently, a Fast Analytic Searching(FAS) module calculates the opening width and the distance of the gripper to the grasp point. By decoupling the grasp detection problem and introducing the stable RGB modality, our pipeline alleviates the requirement for the high-quality depth image and is robust to depth sensor noise. We achieve state-of-the-art results on GraspNet-1Billion dataset compared with several baselines. Real robot experiments on a UR5 robot with an Intel Realsense camera and a Robotiq two-finger gripper show high success rates for both single object scenes and cluttered scenes. Our code and trained model will be made publicly available.