Zhiqiang Que

Xinyang Liu, Xuanyu Liang, Shiqi Ding et al.

The Forward-Forward (FF) algorithm offers a computationally efficient and biologically plausible alternative to backpropagation (BP) by training neural networks through purely local, layer-wise optimization. However, FF is inherently designed for classification via contrastive positive-negative sample pairs, and extending it to regression poses fundamental challenges: continuous target space lack natural "opposites" for contrastive learning, and the standard goodness function carries no information about target magnitude or ordering. We propose FFR (Forward-Forward for Regression), to our knowledge, the first framework to extend FF to real-world regression and demonstrate competitive performance across diverse real-world datasets. FFR introduces three key innovations: (1) an ordinal competitive goodness function that replaces contrastive pairs with competitive learning between partitioned neuron groups under distance-aware ordinal supervision; (2) a stratified ladder architecture where shallow layers learn coarse ordinal discrimination and deeper layers refine into fine-grained regression, with multi-scale feature aggregation for inter-layer collaboration; and (3) hierarchical prediction with uncertainty estimation, where multi-scale predictors jointly provide robust predictions and prediction confidence as a free-lunch. Extensive experimental results show FFR recovers on average 98.6% of BP's accuracy across five real-world regression benchmarks while reducing peak training memory to only 27% of BP's at depth 8 and 8% at depth 32, with per-iteration time around 72% of BP's, and substantially outperforms all BP-free competitors.

Zhiqiang Que, Hongxiang Fan, Marcus Loo et al.

This work presents a novel reconfigurable architecture for Low Latency Graph Neural Network (LL-GNN) designs for particle detectors, delivering unprecedented low latency performance. Incorporating FPGA-based GNNs into particle detectors presents a unique challenge since it requires sub-microsecond latency to deploy the networks for online event selection with a data rate of hundreds of terabytes per second in the Level-1 triggers at the CERN Large Hadron Collider experiments. This paper proposes a novel outer-product based matrix multiplication approach, which is enhanced by exploiting the structured adjacency matrix and a column-major data layout. Moreover, a fusion step is introduced to further reduce the end-to-end design latency by eliminating unnecessary boundaries. Furthermore, a GNN-specific algorithm-hardware co-design approach is presented which not only finds a design with a much better latency but also finds a high accuracy design under given latency constraints. To facilitate this, a customizable template for this low latency GNN hardware architecture has been designed and open-sourced, which enables the generation of low-latency FPGA designs with efficient resource utilization using a high-level synthesis tool. Evaluation results show that our FPGA implementation is up to 9.0 times faster and achieves up to 13.1 times higher power efficiency than a GPU implementation. Compared to the previous FPGA implementations, this work achieves 6.51 to 16.7 times lower latency. Moreover, the latency of our FPGA design is sufficiently low to enable deployment of GNNs in a sub-microsecond, real-time collider trigger system, enabling it to benefit from improved accuracy. The proposed LL-GNN design advances the next generation of trigger systems by enabling sophisticated algorithms to process experimental data efficiently.

Chang Sun, Zhiqiang Que, Bakhtiar Zadeh et al.

Lookup-table (LUT) based neural networks can deliver ultra-low latency and excellent hardware efficiency on FPGAs by mapping arithmetic operations directly onto the logic primitives. However, state-of-the-art LUT-aware training (LAT) approaches remain difficult to use in practice: they are often orders of magnitude slower to train than conventional networks, require non-trivial manual tuning for hardware efficiency, and lack an end-to-end workflow. This work presents HGQ-LUT, integrated in https://github.com/calad0i/HGQ2, a new LAT approach that achieves state-of-the-art hardware efficiency while accelerating training by over 100 times on modern GPUs. HGQ-LUT introduces LUT-Dense and LUT-Conv layers that are implemented with regular, accelerator-efficient tensor operations during training, which are then compiled into logic LUTs for hardware. By combining these layers with fine-grained, element-wise heterogeneous quantization (including zero-bit pruning) and a LUT-aware resource surrogate, HGQ-LUT enables the automatic exploration of accuracy-resource trade-offs without manual bit-width tuning. We further integrate HGQ-LUT into open-source toolchains, enabling unified design, compilation, and bit-exact verification of hybrid architectures that mix LUT-based with conventional arithmetic blocks. These features make LAT-based DNNs practical for real-world deployment, such as at the CERN Large Hadron Collider's experiments.

Ruoqing Zheng, Chang Sun, Qibin Liu et al.

We present JetFormer, a versatile and scalable encoder-only Transformer architecture for particle jet tagging at the Large Hadron Collider (LHC). Unlike prior approaches that are often tailored to specific deployment regimes, JetFormer is designed to operate effectively across the full spectrum of jet tagging scenarios, from high-accuracy offline analysis to ultra-low-latency online triggering. The model processes variable-length sets of particle features without relying on input of explicit pairwise interactions, yet achieves competitive or superior performance compared to state-of-the-art methods. On the large-scale JetClass dataset, a large-scale JetFormer matches the accuracy of the interaction-rich ParT model (within 0.7%) while using 37.4% fewer FLOPs, demonstrating its computational efficiency and strong generalization. On benchmark HLS4ML 150P datasets, JetFormer consistently outperforms existing models such as MLPs, Deep Sets, and Interaction Networks by 3-4% in accuracy. To bridge the gap to hardware deployment, we further introduce a hardware-aware optimization pipeline based on multi-objective hyperparameter search, yielding compact variants like JetFormer-tiny suitable for FPGA-based trigger systems with sub-microsecond latency requirements. Through structured pruning and quantization, we show that JetFormer can be aggressively compressed with minimal accuracy loss. By unifying high-performance modeling and deployability within a single architectural framework, JetFormer provides a practical pathway for deploying Transformer-based jet taggers in both offline and online environments at the LHC. Code is available at https://github.com/walkieq/JetFormer.

Jan-Frederik Schulte, Benjamin Ramhorst, Chang Sun et al.

We present hls4ml, a free and open-source platform that translates machine learning (ML) models from modern deep learning frameworks into high-level synthesis (HLS) code that can be integrated into full designs for field-programmable gate arrays (FPGAs) or application-specific integrated circuits (ASICs). With its flexible and modular design, hls4ml supports a large number of deep learning frameworks and can target HLS compilers from several vendors, including Vitis HLS, Intel oneAPI and Catapult HLS. Together with a wider eco-system for software-hardware co-design, hls4ml has enabled the acceleration of ML inference in a wide range of commercial and scientific applications where low latency, resource usage, and power consumption are critical. In this paper, we describe the structure and functionality of the hls4ml platform. The overarching design considerations for the generated HLS code are discussed, together with selected performance results.

Zhiqiang Que, Shuo Liu, Markus Rognlien et al.

This paper introduces a novel optimization framework for deep neural network (DNN) hardware accelerators, enabling the rapid development of customized and automated design flows. More specifically, our approach aims to automate the selection and configuration of low-level optimization techniques, encompassing DNN and FPGA low-level optimizations. We introduce novel optimization and transformation tasks for building design-flow architectures, which are highly customizable and flexible, thereby enhancing the performance and efficiency of DNN accelerators. Our results demonstrate considerable reductions of up to 92\% in DSP usage and 89\% in LUT usage for two networks, while maintaining accuracy and eliminating the need for human effort or domain expertise. In comparison to state-of-the-art approaches, our design achieves higher accuracy and utilizes three times fewer DSP resources, underscoring the advantages of our proposed framework.

Hongxiang Fan, Hao Chen, Liam Castelli et al.

Bayesian Neural Networks (BayesNNs) have demonstrated their capability of providing calibrated prediction for safety-critical applications such as medical imaging and autonomous driving. However, the high algorithmic complexity and the poor hardware performance of BayesNNs hinder their deployment in real-life applications. To bridge this gap, this paper proposes a novel multi-exit Monte-Carlo Dropout (MCD)-based BayesNN that achieves well-calibrated predictions with low algorithmic complexity. To further reduce the barrier to adopting BayesNNs, we propose a transformation framework that can generate FPGA-based accelerators for multi-exit MCD-based BayesNNs. Several novel optimization techniques are introduced to improve hardware performance. Our experiments demonstrate that our auto-generated accelerator achieves higher energy efficiency than CPU, GPU, and other state-of-the-art hardware implementations.

Chang Sun, Zhiqiang Que, Vladimir Loncar et al.

Neural networks with a latency requirement on the order of microseconds, like the ones used at the CERN Large Hadron Collider, are typically deployed on FPGAs fully unrolled and pipelined. A bottleneck for the deployment of such neural networks is area utilization, which is directly related to the required constant matrix-vector multiplication (CMVM) operations. In this work, we propose an efficient algorithm for implementing CMVM operations with distributed arithmetic (DA) on FPGAs that simultaneously optimizes for area consumption and latency. The algorithm achieves resource reduction similar to state-of-the-art algorithms while being significantly faster to compute. The proposed algorithm is open-sourced and integrated into the \texttt{hls4ml} library, a free and open-source library for running real-time neural network inference on FPGAs. We show that the proposed algorithm can reduce on-chip resources by up to a third for realistic, highly quantized neural networks while simultaneously reducing latency, enabling the implementation of previously infeasible networks.

Zhiqiang Que, Chang Sun, Sudarshan Paramesvaran et al.

Graph Neural Networks (GNNs), particularly Interaction Networks (INs), have shown exceptional performance for jet tagging at the CERN High-Luminosity Large Hadron Collider (HL-LHC). However, their computational complexity and irregular memory access patterns pose significant challenges for deployment on FPGAs in hardware trigger systems, where strict latency and resource constraints apply. In this work, we propose JEDI-linear, a novel GNN architecture with linear computational complexity that eliminates explicit pairwise interactions by leveraging shared transformations and global aggregation. To further enhance hardware efficiency, we introduce fine-grained quantization-aware training with per-parameter bitwidth optimization and employ multiplier-free multiply-accumulate operations via distributed arithmetic. Evaluation results show that our FPGA-based JEDI-linear achieves 3.7 to 11.5 times lower latency, up to 150 times lower initiation interval, and up to 6.2 times lower LUT usage compared to state-of-the-art GNN designs while also delivering higher model accuracy and eliminating the need for DSP blocks entirely. This is the first interaction-based GNN to achieve less than 60~ns latency and currently meets the requirements for use in the HL-LHC CMS Level-1 trigger system. This work advances the next-generation trigger systems by enabling accurate, scalable, and resource-efficient GNN inference in real-time environments. Our open-sourced templates will further support reproducibility and broader adoption across scientific applications.

Patrick Odagiu, Zhiqiang Que, Javier Duarte et al.

Three machine learning models are used to perform jet origin classification. These models are optimized for deployment on a field-programmable gate array device. In this context, we demonstrate how latency and resource consumption scale with the input size and choice of algorithm. Moreover, the models proposed here are designed to work on the type of data and under the foreseen conditions at the CERN LHC during its high-luminosity phase. Through quantization-aware training and efficient synthetization for a specific field programmable gate array, we show that $O(100)$ ns inference of complex architectures such as Deep Sets and Interaction Networks is feasible at a relatively low computational resource cost.

Elizabeth G. Campolongo, Yuan-Tang Chou, Ekaterina Govorkova et al.

Scientific discoveries are often made by finding a pattern or object that was not predicted by the known rules of science. Oftentimes, these anomalous events or objects that do not conform to the norms are an indication that the rules of science governing the data are incomplete, and something new needs to be present to explain these unexpected outliers. The challenge of finding anomalies can be confounding since it requires codifying a complete knowledge of the known scientific behaviors and then projecting these known behaviors on the data to look for deviations. When utilizing machine learning, this presents a particular challenge since we require that the model not only understands scientific data perfectly but also recognizes when the data is inconsistent and out of the scope of its trained behavior. In this paper, we present three datasets aimed at developing machine learning-based anomaly detection for disparate scientific domains covering astrophysics, genomics, and polar science. We present the different datasets along with a scheme to make machine learning challenges around the three datasets findable, accessible, interoperable, and reusable (FAIR). Furthermore, we present an approach that generalizes to future machine learning challenges, enabling the possibility of large, more compute-intensive challenges that can ultimately lead to scientific discovery.

Zhiqiang Que, Jose G. F. Coutinho, Ce Guo et al.

This paper presents a unified framework for codifying and automating optimization strategies to efficiently deploy deep neural networks (DNNs) on resource-constrained hardware, such as FPGAs, while maintaining high performance, accuracy, and resource efficiency. Deploying DNNs on such platforms involves addressing the significant challenge of balancing performance, resource usage (e.g., DSPs and LUTs), and inference accuracy, which often requires extensive manual effort and domain expertise. Our novel approach addresses two core key issues: (i)~encoding custom optimization strategies and (ii)~enabling cross-stage optimization search. In particular, our proposed framework seamlessly integrates programmatic DNN optimization techniques with high-level synthesis (HLS)-based metaprogramming, leveraging advanced design space exploration (DSE) strategies like Bayesian optimization to automate both top-down and bottom-up design flows. Hence, we reduce the need for manual intervention and domain expertise. In addition, the framework introduces customizable optimization, transformation, and control blocks to enhance DNN accelerator performance and resource efficiency. Experimental results demonstrate up to a 92\% DSP and 89\% LUT usage reduction for select networks, while preserving accuracy, along with a 15.6-fold reduction in optimization time compared to grid search. These results highlight the potential for automating the generation of resource-efficient DNN accelerator designs with minimum effort.

Guanxi Lu, Hao Mark Chen, Zhiqiang Que et al.

Large language models (LLMs) have shown promising performance across various tasks. However, their autoregressive decoding process poses significant challenges for efficient deployment on existing AI hardware. Quantization alleviates memory and compute pressure by compressing weights, activations, and KV caches to low precisions while preserving generation quality. However, existing quantization frameworks typically focus on perplexity or classification accuracy, often omitting critical trustworthiness metrics. This gap introduces risks when applying quantized LLMs to downstream high-stakes domains such as finance and healthcare. In this work, we systematically investigate the impact of quantization on four trustworthiness metrics (adversarial robustness, fairness, machine ethics, and out-of-distribution robustness) and identify the instability across compression ratios and quantization methods. Building on these observations, we develop a novel precision-ensemble voting approach that leverages predictions from mixed-precision variants of the same model and consistently improves performance by up to $5.8\%$ on trustworthiness metrics. Our results highlight the importance of considering trustworthiness when developing model compression techniques and point to research opportunities at the intersection of compression and trustworthiness for safety-critical applications.

Lauri Laatu, Chang Sun, Arianna Cox et al.

We present the first sub-microsecond transformer implementation on an FPGA achieving competitive performance for state-of-the-art high-energy physics benchmarks. Transformers have shown exceptional performance on multiple tasks in modern machine learning applications, including jet tagging at the CERN Large Hadron Collider (LHC). However, their computational complexity prohibits use in real-time applications, such as the hardware trigger system of the collider experiments up until now. In this work, we demonstrate the first application of transformers for jet tagging on FPGAs, achieving $\mathcal{O}(100)$ nanosecond latency with superior performance compared to alternative baseline models. We leverage high-granularity quantization and distributed arithmetic optimization to fit the entire transformer model on a single FPGA, achieving the required throughput and latency. Furthermore, we add multi-head attention and linear attention support to hls4ml, making our work accessible to the broader fast machine learning community. This work advances the next-generation trigger systems for the High Luminosity LHC, enabling the use of transformers for real-time applications in high-energy physics and beyond.

Hongxiang Fan, Martin Ferianc, Zhiqiang Que et al.

Recent advances in algorithm-hardware co-design for deep neural networks (DNNs) have demonstrated their potential in automatically designing neural architectures and hardware designs. Nevertheless, it is still a challenging optimization problem due to the expensive training cost and the time-consuming hardware implementation, which makes the exploration on the vast design space of neural architecture and hardware design intractable. In this paper, we demonstrate that our proposed approach is capable of locating designs on the Pareto frontier. This capability is enabled by a novel three-phase co-design framework, with the following new features: (a) decoupling DNN training from the design space exploration of hardware architecture and neural architecture, (b) providing a hardware-friendly neural architecture space by considering hardware characteristics in constructing the search cells, (c) adopting Gaussian process to predict accuracy, latency and power consumption to avoid time-consuming synthesis and place-and-route processes. In comparison with the manually-designed ResNet101, InceptionV2 and MobileNetV2, we can achieve up to 5% higher accuracy with up to 3x speed up on the ImageNet dataset. Compared with other state-of-the-art co-design frameworks, our found network and hardware configuration can achieve 2% ~ 6% higher accuracy, 2x ~ 26x smaller latency and 8.5x higher energy efficiency.

Allison McCarn Deiana, Nhan Tran, Joshua Agar et al.

In this community review report, we discuss applications and techniques for fast machine learning (ML) in science -- the concept of integrating power ML methods into the real-time experimental data processing loop to accelerate scientific discovery. The material for the report builds on two workshops held by the Fast ML for Science community and covers three main areas: applications for fast ML across a number of scientific domains; techniques for training and implementing performant and resource-efficient ML algorithms; and computing architectures, platforms, and technologies for deploying these algorithms. We also present overlapping challenges across the multiple scientific domains where common solutions can be found. This community report is intended to give plenty of examples and inspiration for scientific discovery through integrated and accelerated ML solutions. This is followed by a high-level overview and organization of technical advances, including an abundance of pointers to source material, which can enable these breakthroughs.

Zhiqiang Que, Erwei Wang, Umar Marikar et al.

This paper presents novel reconfigurable architectures for reducing the latency of recurrent neural networks (RNNs) that are used for detecting gravitational waves. Gravitational interferometers such as the LIGO detectors capture cosmic events such as black hole mergers which happen at unknown times and of varying durations, producing time-series data. We have developed a new architecture capable of accelerating RNN inference for analyzing time-series data from LIGO detectors. This architecture is based on optimizing the initiation intervals (II) in a multi-layer LSTM (Long Short-Term Memory) network, by identifying appropriate reuse factors for each layer. A customizable template for this architecture has been designed, which enables the generation of low-latency FPGA designs with efficient resource utilization using high-level synthesis tools. The proposed approach has been evaluated based on two LSTM models, targeting a ZYNQ 7045 FPGA and a U250 FPGA. Experimental results show that with balanced II, the number of DSPs can be reduced up to 42% while achieving the same IIs. When compared to other FPGA-based LSTM designs, our design can achieve about 4.92 to 12.4 times lower latency.

Martin Ferianc, Zhiqiang Que, Hongxiang Fan et al.

Neural networks have demonstrated their outstanding performance in a wide range of tasks. Specifically recurrent architectures based on long-short term memory (LSTM) cells have manifested excellent capability to model time dependencies in real-world data. However, standard recurrent architectures cannot estimate their uncertainty which is essential for safety-critical applications such as in medicine. In contrast, Bayesian recurrent neural networks (RNNs) are able to provide uncertainty estimation with improved accuracy. Nonetheless, Bayesian RNNs are computationally and memory demanding, which limits their practicality despite their advantages. To address this issue, we propose an FPGA-based hardware design to accelerate Bayesian LSTM-based RNNs. To further improve the overall algorithmic-hardware performance, a co-design framework is proposed to explore the most fitting algorithmic-hardware configurations for Bayesian RNNs. We conduct extensive experiments on healthcare applications to demonstrate the improvement of our design and the effectiveness of our framework. Compared with GPU implementation, our FPGA-based design can achieve up to 10 times speedup with nearly 106 times higher energy efficiency. To the best of our knowledge, this is the first work targeting acceleration of Bayesian RNNs on FPGAs.