Shengshan Hu

Qiufan Ji, Lin Wang, Cong Shi et al.

Deep Neural Networks (DNNs) for 3D point cloud recognition are vulnerable to adversarial examples, threatening their practical deployment. Despite the many research endeavors have been made to tackle this issue in recent years, the diversity of adversarial examples on 3D point clouds makes them more challenging to defend against than those on 2D images. For examples, attackers can generate adversarial examples by adding, shifting, or removing points. Consequently, existing defense strategies are hard to counter unseen point cloud adversarial examples. In this paper, we first establish a comprehensive, and rigorous point cloud adversarial robustness benchmark to evaluate adversarial robustness, which can provide a detailed understanding of the effects of the defense and attack methods. We then collect existing defense tricks in point cloud adversarial defenses and then perform extensive and systematic experiments to identify an effective combination of these tricks. Furthermore, we propose a hybrid training augmentation methods that consider various types of point cloud adversarial examples to adversarial training, significantly improving the adversarial robustness. By combining these tricks, we construct a more robust defense framework achieving an average accuracy of 83.45\% against various attacks, demonstrating its capability to enabling robust learners. Our codebase are open-sourced on: \url{https://github.com/qiufan319/benchmark_pc_attack.git}.

Zhaoxi Zhang, Leo Yu Zhang, Xufei Zheng et al.

The usage of deep learning is being escalated in many applications. Due to its outstanding performance, it is being used in a variety of security and privacy-sensitive areas in addition to conventional applications. One of the key aspects of deep learning efficacy is to have abundant data. This trait leads to the usage of data which can be highly sensitive and private, which in turn causes wariness with regard to deep learning in the general public. Membership inference attacks are considered lethal as they can be used to figure out whether a piece of data belongs to the training dataset or not. This can be problematic with regards to leakage of training data information and its characteristics. To highlight the significance of these types of attacks, we propose an enhanced methodology for membership inference attacks based on adversarial robustness, by adjusting the directions of adversarial perturbations through label smoothing under a white-box setting. We evaluate our proposed method on three datasets: Fashion-MNIST, CIFAR-10, and CIFAR-100. Our experimental results reveal that the performance of our method surpasses that of the existing adversarial robustness-based method when attacking normally trained models. Additionally, through comparing our technique with the state-of-the-art metric-based membership inference methods, our proposed method also shows better performance when attacking adversarially trained models. The code for reproducing the results of this work is available at \url{https://github.com/plll4zzx/Evaluating-Membership-Inference-Through-Adversarial-Robustness}.

Xiaomei Zhang, Zhaoxi Zhang, Qi Zhong et al.

Adversarial attacks are a serious threat to the reliable deployment of machine learning models in safety-critical applications. They can misguide current models to predict incorrectly by slightly modifying the inputs. Recently, substantial work has shown that adversarial examples tend to deviate from the underlying data manifold of normal examples, whereas pre-trained masked language models can fit the manifold of normal NLP data. To explore how to use the masked language model in adversarial detection, we propose a novel textual adversarial example detection method, namely Masked Language Model-based Detection (MLMD), which can produce clearly distinguishable signals between normal examples and adversarial examples by exploring the changes in manifolds induced by the masked language model. MLMD features a plug and play usage (i.e., no need to retrain the victim model) for adversarial defense and it is agnostic to classification tasks, victim model's architectures, and to-be-defended attack methods. We evaluate MLMD on various benchmark textual datasets, widely studied machine learning models, and state-of-the-art (SOTA) adversarial attacks (in total $3*4*4 = 48$ settings). Experimental results show that MLMD can achieve strong performance, with detection accuracy up to 0.984, 0.967, and 0.901 on AG-NEWS, IMDB, and SST-2 datasets, respectively. Additionally, MLMD is superior, or at least comparable to, the SOTA detection defenses in detection accuracy and F1 score. Among many defenses based on the off-manifold assumption of adversarial examples, this work offers a new angle for capturing the manifold change. The code for this work is openly accessible at \url{https://github.com/mlmddetection/MLMDdetection}.

Shengshan Hu, Junwei Zhang, Wei Liu et al.

Point cloud completion, as the upstream procedure of 3D recognition and segmentation, has become an essential part of many tasks such as navigation and scene understanding. While various point cloud completion models have demonstrated their powerful capabilities, their robustness against adversarial attacks, which have been proven to be fatally malicious towards deep neural networks, remains unknown. In addition, existing attack approaches towards point cloud classifiers cannot be applied to the completion models due to different output forms and attack purposes. In order to evaluate the robustness of the completion models, we propose PointCA, the first adversarial attack against 3D point cloud completion models. PointCA can generate adversarial point clouds that maintain high similarity with the original ones, while being completed as another object with totally different semantic information. Specifically, we minimize the representation discrepancy between the adversarial example and the target point set to jointly explore the adversarial point clouds in the geometry space and the feature space. Furthermore, to launch a stealthier attack, we innovatively employ the neighbourhood density information to tailor the perturbation constraint, leading to geometry-aware and distribution-adaptive modifications for each point. Extensive experiments against different premier point cloud completion networks show that PointCA can cause a performance degradation from 77.9% to 16.7%, with the structure chamfer distance kept below 0.01. We conclude that existing completion models are severely vulnerable to adversarial examples, and state-of-the-art defenses for point cloud classification will be partially invalid when applied to incomplete and uneven point cloud data.

Xiaogeng Liu, Minghui Li, Haoyu Wang et al.

Deep neural networks are proven to be vulnerable to backdoor attacks. Detecting the trigger samples during the inference stage, i.e., the test-time trigger sample detection, can prevent the backdoor from being triggered. However, existing detection methods often require the defenders to have high accessibility to victim models, extra clean data, or knowledge about the appearance of backdoor triggers, limiting their practicality. In this paper, we propose the test-time corruption robustness consistency evaluation (TeCo), a novel test-time trigger sample detection method that only needs the hard-label outputs of the victim models without any extra information. Our journey begins with the intriguing observation that the backdoor-infected models have similar performance across different image corruptions for the clean images, but perform discrepantly for the trigger samples. Based on this phenomenon, we design TeCo to evaluate test-time robustness consistency by calculating the deviation of severity that leads to predictions' transition across different corruptions. Extensive experiments demonstrate that compared with state-of-the-art defenses, which even require either certain information about the trigger types or accessibility of clean data, TeCo outperforms them on different backdoor attacks, datasets, and model architectures, enjoying a higher AUROC by 10% and 5 times of stability.

Ziqi Zhou, Shengshan Hu, Ruizhi Zhao et al.

Self-supervised learning usually uses a large amount of unlabeled data to pre-train an encoder which can be used as a general-purpose feature extractor, such that downstream users only need to perform fine-tuning operations to enjoy the benefit of "large model". Despite this promising prospect, the security of pre-trained encoder has not been thoroughly investigated yet, especially when the pre-trained encoder is publicly available for commercial use. In this paper, we propose AdvEncoder, the first framework for generating downstream-agnostic universal adversarial examples based on the pre-trained encoder. AdvEncoder aims to construct a universal adversarial perturbation or patch for a set of natural images that can fool all the downstream tasks inheriting the victim pre-trained encoder. Unlike traditional adversarial example works, the pre-trained encoder only outputs feature vectors rather than classification labels. Therefore, we first exploit the high frequency component information of the image to guide the generation of adversarial examples. Then we design a generative attack framework to construct adversarial perturbations/patches by learning the distribution of the attack surrogate dataset to improve their attack success rates and transferability. Our results show that an attacker can successfully attack downstream tasks without knowing either the pre-training dataset or the downstream dataset. We also tailor four defenses for pre-trained encoders, the results of which further prove the attack ability of AdvEncoder.

Shengshan Hu, Xiaogeng Liu, Yechao Zhang et al.

While deep face recognition (FR) systems have shown amazing performance in identification and verification, they also arouse privacy concerns for their excessive surveillance on users, especially for public face images widely spread on social networks. Recently, some studies adopt adversarial examples to protect photos from being identified by unauthorized face recognition systems. However, existing methods of generating adversarial face images suffer from many limitations, such as awkward visual, white-box setting, weak transferability, making them difficult to be applied to protect face privacy in reality. In this paper, we propose adversarial makeup transfer GAN (AMT-GAN), a novel face protection method aiming at constructing adversarial face images that preserve stronger black-box transferability and better visual quality simultaneously. AMT-GAN leverages generative adversarial networks (GAN) to synthesize adversarial face images with makeup transferred from reference images. In particular, we introduce a new regularization module along with a joint training strategy to reconcile the conflicts between the adversarial noises and the cycle consistence loss in makeup transfer, achieving a desirable balance between the attack strength and visual changes. Extensive experiments verify that compared with state of the arts, AMT-GAN can not only preserve a comfortable visual quality, but also achieve a higher attack success rate over commercial FR APIs, including Face++, Aliyun, and Microsoft.

Ziqi Zhou, Shengshan Hu, Minghui Li et al.

Multimodal contrastive learning aims to train a general-purpose feature extractor, such as CLIP, on vast amounts of raw, unlabeled paired image-text data. This can greatly benefit various complex downstream tasks, including cross-modal image-text retrieval and image classification. Despite its promising prospect, the security issue of cross-modal pre-trained encoder has not been fully explored yet, especially when the pre-trained encoder is publicly available for commercial use. In this work, we propose AdvCLIP, the first attack framework for generating downstream-agnostic adversarial examples based on cross-modal pre-trained encoders. AdvCLIP aims to construct a universal adversarial patch for a set of natural images that can fool all the downstream tasks inheriting the victim cross-modal pre-trained encoder. To address the challenges of heterogeneity between different modalities and unknown downstream tasks, we first build a topological graph structure to capture the relevant positions between target samples and their neighbors. Then, we design a topology-deviation based generative adversarial network to generate a universal adversarial patch. By adding the patch to images, we minimize their embeddings similarity to different modality and perturb the sample distribution in the feature space, achieving unviersal non-targeted attacks. Our results demonstrate the excellent attack performance of AdvCLIP on two types of downstream tasks across eight datasets. We also tailor three popular defenses to mitigate AdvCLIP, highlighting the need for new defense mechanisms to defend cross-modal pre-trained encoders.

Hangtao Zhang, Zeming Yao, Leo Yu Zhang et al.

Federated learning (FL) is vulnerable to poisoning attacks, where adversaries corrupt the global aggregation results and cause denial-of-service (DoS). Unlike recent model poisoning attacks that optimize the amplitude of malicious perturbations along certain prescribed directions to cause DoS, we propose a Flexible Model Poisoning Attack (FMPA) that can achieve versatile attack goals. We consider a practical threat scenario where no extra knowledge about the FL system (e.g., aggregation rules or updates on benign devices) is available to adversaries. FMPA exploits the global historical information to construct an estimator that predicts the next round of the global model as a benign reference. It then fine-tunes the reference model to obtain the desired poisoned model with low accuracy and small perturbations. Besides the goal of causing DoS, FMPA can be naturally extended to launch a fine-grained controllable attack, making it possible to precisely reduce the global accuracy. Armed with precise control, malicious FL service providers can gain advantages over their competitors without getting noticed, hence opening a new attack surface in FL other than DoS. Even for the purpose of DoS, experiments show that FMPA significantly decreases the global accuracy, outperforming six state-of-the-art attacks.

Shengshan Hu, Ziqi Zhou, Yechao Zhang et al.

Due to its powerful feature learning capability and high efficiency, deep hashing has achieved great success in large-scale image retrieval. Meanwhile, extensive works have demonstrated that deep neural networks (DNNs) are susceptible to adversarial examples, and exploring adversarial attack against deep hashing has attracted many research efforts. Nevertheless, backdoor attack, another famous threat to DNNs, has not been studied for deep hashing yet. Although various backdoor attacks have been proposed in the field of image classification, existing approaches failed to realize a truly imperceptive backdoor attack that enjoys invisible triggers and clean label setting simultaneously, and they also cannot meet the intrinsic demand of image retrieval backdoor. In this paper, we propose BadHash, the first generative-based imperceptible backdoor attack against deep hashing, which can effectively generate invisible and input-specific poisoned images with clean label. Specifically, we first propose a new conditional generative adversarial network (cGAN) pipeline to effectively generate poisoned samples. For any given benign image, it seeks to generate a natural-looking poisoned counterpart with a unique invisible trigger. In order to improve the attack effectiveness, we introduce a label-based contrastive learning network LabCLN to exploit the semantic characteristics of different labels, which are subsequently used for confusing and misleading the target model to learn the embedded trigger. We finally explore the mechanism of backdoor attacks on image retrieval in the hash space. Extensive experiments on multiple benchmark datasets verify that BadHash can generate imperceptible poisoned samples with strong attack ability and transferability over state-of-the-art deep hashing schemes.

Yechao Zhang, Shengshan Hu, Leo Yu Zhang et al.

Adversarial examples (AEs) for DNNs have been shown to be transferable: AEs that successfully fool white-box surrogate models can also deceive other black-box models with different architectures. Although a bunch of empirical studies have provided guidance on generating highly transferable AEs, many of these findings lack explanations and even lead to inconsistent advice. In this paper, we take a further step towards understanding adversarial transferability, with a particular focus on surrogate aspects. Starting from the intriguing little robustness phenomenon, where models adversarially trained with mildly perturbed adversarial samples can serve as better surrogates, we attribute it to a trade-off between two predominant factors: model smoothness and gradient similarity. Our investigations focus on their joint effects, rather than their separate correlations with transferability. Through a series of theoretical and empirical analyses, we conjecture that the data distribution shift in adversarial training explains the degradation of gradient similarity. Building on these insights, we explore the impacts of data augmentation and gradient regularization on transferability and identify that the trade-off generally exists in the various training mechanisms, thus building a comprehensive blueprint for the regulation mechanism behind transferability. Finally, we provide a general route for constructing better surrogates to boost transferability which optimizes both model smoothness and gradient similarity simultaneously, e.g., the combination of input gradient regularization and sharpness-aware minimization (SAM), validated by extensive experiments. In summary, we call for attention to the united impacts of these two factors for launching effective transfer attacks, rather than optimizing one while ignoring the other, and emphasize the crucial role of manipulating surrogate models.

Xianlong Wang, Hewen Pan, Hangtao Zhang et al.

Robotic manipulation policies are increasingly empowered by \textit{large language models} (LLMs) and \textit{vision-language models} (VLMs), leveraging their understanding and perception capabilities. Recently, inference-time attacks against robotic manipulation have been extensively studied, yet backdoor attacks targeting model supply chain security in robotic policies remain largely unexplored. To fill this gap, we propose \texttt{TrojanRobot}, a backdoor injection framework for model supply chain attack scenarios, which embeds a malicious module into modular robotic policies via backdoor relationships to manipulate the LLM-to-VLM pathway and compromise the system. Our vanilla design instantiates this module as a backdoor-finetuned VLM. To further enhance attack performance, we propose a prime scheme by introducing the concept of \textit{LVLM-as-a-backdoor}, which leverages \textit{in-context instruction learning} (ICIL) to steer \textit{large vision-language model} (LVLM) behavior through backdoored system prompts. Moreover, we develop three types of prime attacks, \textit{permutation}, \textit{stagnation}, and \textit{intentional}, achieving flexible backdoor attack effects. Extensive physical-world and simulator experiments on 18 real-world manipulation tasks and 4 VLMs verify the superiority of proposed \texttt{TrojanRobot}

Di Mi, Yanjun Zhang, Leo Yu Zhang et al.

Model extraction attacks (MEAs) enable an attacker to replicate the functionality of a victim deep neural network (DNN) model by only querying its API service remotely, posing a severe threat to the security and integrity of pay-per-query DNN-based services. Although the majority of current research on MEAs has primarily concentrated on neural classifiers, there is a growing prevalence of image-to-image translation (I2IT) tasks in our everyday activities. However, techniques developed for MEA of DNN classifiers cannot be directly transferred to the case of I2IT, rendering the vulnerability of I2IT models to MEA attacks often underestimated. This paper unveils the threat of MEA in I2IT tasks from a new perspective. Diverging from the traditional approach of bridging the distribution gap between attacker queries and victim training samples, we opt to mitigate the effect caused by the different distributions, known as the domain shift. This is achieved by introducing a new regularization term that penalizes high-frequency noise, and seeking a flatter minimum to avoid overfitting to the shifted distribution. Extensive experiments on different image translation tasks, including image super-resolution and style transfer, are performed on different backbone victim models, and the new design consistently outperforms the baseline by a large margin across all metrics. A few real-life I2IT APIs are also verified to be extremely vulnerable to our attack, emphasizing the need for enhanced defenses and potentially revised API publishing policies.

Qi Zhong, Leo Yu Zhang, Shengshan Hu et al.

Fine-tuning attacks are effective in removing the embedded watermarks in deep learning models. However, when the source data is unavailable, it is challenging to just erase the watermark without jeopardizing the model performance. In this context, we introduce Attention Distraction (AD), a novel source data-free watermark removal attack, to make the model selectively forget the embedded watermarks by customizing continual learning. In particular, AD first anchors the model's attention on the main task using some unlabeled data. Then, through continual learning, a small number of \textit{lures} (randomly selected natural images) that are assigned a new label distract the model's attention away from the watermarks. Experimental results from different datasets and networks corroborate that AD can thoroughly remove the watermark with a small resource budget without compromising the model's performance on the main task, which outperforms the state-of-the-art works.

Xiaogeng Liu, Haoyu Wang, Yechao Zhang et al.

The data-centric machine learning aims to find effective ways to build appropriate datasets which can improve the performance of AI models. In this paper, we mainly focus on designing an efficient data-centric scheme to improve robustness for models towards unforeseen malicious inputs in the black-box test settings. Specifically, we introduce a noised-based data augmentation method which is composed of Gaussian Noise, Salt-and-Pepper noise, and the PGD adversarial perturbations. The proposed method is built on lightweight algorithms and proved highly effective based on comprehensive evaluations, showing good efficiency on computation cost and robustness enhancement. In addition, we share our insights about the data-centric robust machine learning gained from our experiments.

Ziqi Zhou, Yufei Song, Minghui Li et al.

Segment Anything Model (SAM) has recently gained much attention for its outstanding generalization to unseen data and tasks. Despite its promising prospect, the vulnerabilities of SAM, especially to universal adversarial perturbation (UAP) have not been thoroughly investigated yet. In this paper, we propose DarkSAM, the first prompt-free universal attack framework against SAM, including a semantic decoupling-based spatial attack and a texture distortion-based frequency attack. We first divide the output of SAM into foreground and background. Then, we design a shadow target strategy to obtain the semantic blueprint of the image as the attack target. DarkSAM is dedicated to fooling SAM by extracting and destroying crucial object features from images in both spatial and frequency domains. In the spatial domain, we disrupt the semantics of both the foreground and background in the image to confuse SAM. In the frequency domain, we further enhance the attack effectiveness by distorting the high-frequency components (i.e., texture information) of the image. Consequently, with a single UAP, DarkSAM renders SAM incapable of segmenting objects across diverse images with varying prompts. Experimental results on four datasets for SAM and its two variant models demonstrate the powerful attack capability and transferability of DarkSAM.

Long Tang, Dengpan Ye, Zhenhao Lu et al.

Adversarial example is a rising way of protecting facial privacy security from deepfake modification. To prevent massive facial images from being illegally modified by various deepfake models, it is essential to design a universal deepfake disruptor. However, existing works treat deepfake disruption as an End-to-End process, ignoring the functional difference between feature extraction and image reconstruction, which makes it difficult to generate a cross-model universal disruptor. In this work, we propose a novel Feature-Output ensemble UNiversal Disruptor (FOUND) against deepfake networks, which explores a new opinion that considers attacking feature extractors as the more critical and general task in deepfake disruption. We conduct an effective two-stage disruption process. We first disrupt multi-model feature extractors through multi-feature aggregation and individual-feature maintenance, and then develop a gradient-ensemble algorithm to enhance the disruption effect by simplifying the complex optimization problem of disrupting multiple End-to-End models. Extensive experiments demonstrate that FOUND can significantly boost the disruption effect against ensemble deepfake benchmark models. Besides, our method can fast obtain a cross-attribute, cross-image, and cross-model universal deepfake disruptor with only a few training images, surpassing state-of-the-art universal disruptors in both success rate and efficiency.

Fuyi Wang, Leo Yu Zhang, Lei Pan et al.

Machine learning promotes the continuous development of signal processing in various fields, including network traffic monitoring, EEG classification, face identification, and many more. However, massive user data collected for training deep learning models raises privacy concerns and increases the difficulty of manually adjusting the network structure. To address these issues, we propose a privacy-preserving neural architecture search (PP-NAS) framework based on secure multi-party computation to protect users' data and the model's parameters/hyper-parameters. PP-NAS outsources the NAS task to two non-colluding cloud servers for making full advantage of mixed protocols design. Complement to the existing PP machine learning frameworks, we redesign the secure ReLU and Max-pooling garbled circuits for significantly better efficiency ($3 \sim 436$ times speed-up). We develop a new alternative to approximate the Softmax function over secret shares, which bypasses the limitation of approximating exponential operations in Softmax while improving accuracy. Extensive analyses and experiments demonstrate PP-NAS's superiority in security, efficiency, and accuracy.

Minghui Li, Jiangxiong Wang, Hao Zhang et al.

The success of deep face recognition (FR) systems has raised serious privacy concerns due to their ability to enable unauthorized tracking of users in the digital world. Previous studies proposed introducing imperceptible adversarial noises into face images to deceive those face recognition models, thus achieving the goal of enhancing facial privacy protection. Nevertheless, they heavily rely on user-chosen references to guide the generation of adversarial noises, and cannot simultaneously construct natural and highly transferable adversarial face images in black-box scenarios. In light of this, we present a novel face privacy protection scheme with improved transferability while maintain high visual quality. We propose shaping the entire face space directly instead of exploiting one kind of facial characteristic like makeup information to integrate adversarial noises. To achieve this goal, we first exploit global adversarial latent search to traverse the latent space of the generative model, thereby creating natural adversarial face images with high transferability. We then introduce a key landmark regularization module to preserve the visual identity information. Finally, we investigate the impacts of various kinds of latent spaces and find that $\mathcal{F}$ latent space benefits the trade-off between visual naturalness and adversarial transferability. Extensive experiments over two datasets demonstrate that our approach significantly enhances attack transferability while maintaining high visual quality, outperforming state-of-the-art methods by an average 25% improvement in deep FR models and 10% improvement on commercial FR APIs, including Face++, Aliyun, and Tencent.

Lulu Xue, Shengshan Hu, Linqiang Qian et al.

Machine unlearning is a newly popularized technique for removing specific training data from a trained model, enabling it to comply with data deletion requests. While it protects the rights of users requesting unlearning, it also introduces new privacy risks. Prior works have primarily focused on the privacy of data that has been unlearned, while the risks to retained data remain largely unexplored. To address this gap, we focus on the privacy risks of retained data and, for the first time, reveal the vulnerabilities introduced by machine unlearning under the dual-view setting, where an adversary can query both the original and the unlearned models. From an information-theoretic perspective, we introduce the concept of {privacy knowledge gain} and demonstrate that the dual-view setting allows adversaries to obtain more information than querying either model alone, thereby amplifying privacy leakage. To effectively demonstrate this threat, we propose DVIA, a Dual-View Inference Attack, which extracts membership information on retained data using black-box queries to both models. DVIA eliminates the need to train an attack model and employs a lightweight likelihood ratio inference module for efficient inference. Experiments across different datasets and model architectures validate the effectiveness of DVIA and highlight the privacy risks inherent in the dual-view setting.

Minghui Li, Xianlong Wang, Zhifei Yu et al.

Convolution-based unlearnable examples (UEs) employ class-wise multiplicative convolutional noise to training samples, severely compromising model performance. This fire-new type of UEs have successfully countered all defense mechanisms against UEs. The failure of such defenses can be attributed to the absence of norm constraints on convolutional noise, leading to severe blurring of image features. To address this, we first design an Edge Pixel-based Detector (EPD) to identify convolution-based UEs. Upon detection of them, we propose the first defense scheme against convolution-based UEs, COrrupting these samples via random matrix multiplication by employing bilinear INterpolation (COIN) such that disrupting the distribution of class-wise multiplicative noise. To evaluate the generalization of our proposed COIN, we newly design two convolution-based UEs called VUDA and HUDA to expand the scope of convolution-based UEs. Extensive experiments demonstrate the effectiveness of detection scheme EPD and that our defense COIN outperforms 11 state-of-the-art (SOTA) defenses, achieving a significant improvement on the CIFAR and ImageNet datasets.

Minghui Li, Yuanhang Wang, Peijin Guo et al.

Accurate prediction of Drug-Target Affinity (DTA) is crucial for reducing experimental costs and accelerating early screening in computational drug discovery. While sequence-based deep learning methods avoid reliance on costly 3D structures, they still overlook simultaneous modeling of global sequence semantic features and local topological structural features within drugs and proteins, and represent drugs as flat sequences without atomic-level, substructural-level, and molecular-level multi-scale features. We propose HiF-DTA, a hierarchical network that adopts a dual-pathway strategy to extract both global sequence semantic and local topological features from drug and protein sequences, and models drugs multi-scale to learn atomic, substructural, and molecular representations fused via a multi-scale bilinear attention module. Experiments on Davis, KIBA, and Metz datasets show HiF-DTA outperforms state-of-the-art baselines, with ablations confirming the importance of global-local extraction and multi-scale fusion.

Peijin Guo, Minghui Li, Hewen Pan et al.

While deep learning models play a crucial role in predicting antibody-antigen interactions (AAI), the scarcity of publicly available sequence-structure pairings constrains their generalization. Current AAI methods often focus on residue-level static details, overlooking fine-grained structural representations of antibodies and their inter-antibody similarities. To tackle this challenge, we introduce a multi-modality representation approach that integates 3D structural and 1D sequence data to unravel intricate intra-antibody hierarchical relationships. By harnessing these representations, we present MuLAAIP, an AAI prediction framework that utilizes graph attention networks to illuminate graph-level structural features and normalized adaptive graph convolution networks to capture inter-antibody sequence associations. Furthermore, we have curated an AAI benchmark dataset comprising both structural and sequence information along with interaction labels. Through extensive experiments on this benchmark, our results demonstrate that MuLAAIP outperforms current state-of-the-art methods in terms of predictive performance. The implementation code and dataset are publicly available at https://github.com/trashTian/MuLAAIP for reproducibility.

Junyu Shi, Minghui Li, Junguo Zuo et al.

Deepfakes, leveraging advanced AIGC (Artificial Intelligence-Generated Content) techniques, create hyper-realistic synthetic images and videos of human faces, posing a significant threat to the authenticity of social media. While this real-world threat is increasingly prevalent, existing academic evaluations and benchmarks for detecting deepfake forgery often fall short to achieve effective application for their lack of specificity, limited deepfake diversity, restricted manipulation techniques.To address these limitations, we introduce RedFace (Real-world-oriented Deepfake Face), a specialized facial deepfake dataset, comprising over 60,000 forged images and 1,000 manipulated videos derived from authentic facial features, to bridge the gap between academic evaluations and real-world necessity. Unlike prior benchmarks, which typically rely on academic methods to generate deepfakes, RedFace utilizes 9 commercial online platforms to integrate the latest deepfake technologies found "in the wild", effectively simulating real-world black-box scenarios.Moreover, RedFace's deepfakes are synthesized using bespoke algorithms, allowing it to capture diverse and evolving methods used by real-world deepfake creators. Extensive experimental results on RedFace (including cross-domain, intra-domain, and real-world social network dissemination simulations) verify the limited practicality of existing deepfake detection schemes against real-world applications. We further perform a detailed analysis of the RedFace dataset, elucidating the reason of its impact on detection performance compared to conventional datasets. Our dataset is available at: https://github.com/kikyou-220/RedFace.

Xianlong Wang, Shengshan Hu, Yechao Zhang et al.

Clean-label indiscriminate poisoning attacks add invisible perturbations to correctly labeled training images, thus dramatically reducing the generalization capability of the victim models. Recently, some defense mechanisms have been proposed such as adversarial training, image transformation techniques, and image purification. However, these schemes are either susceptible to adaptive attacks, built on unrealistic assumptions, or only effective against specific poison types, limiting their universal applicability. In this research, we propose a more universally effective, practical, and robust defense scheme called ECLIPSE. We first investigate the impact of Gaussian noise on the poisons and theoretically prove that any kind of poison will be largely assimilated when imposing sufficient random noise. In light of this, we assume the victim has access to an extremely limited number of clean images (a more practical scene) and subsequently enlarge this sparse set for training a denoising probabilistic model (a universal denoising tool). We then begin by introducing Gaussian noise to absorb the poisons and then apply the model for denoising, resulting in a roughly purified dataset. Finally, to address the trade-off of the inconsistency in the assimilation sensitivity of different poisons by Gaussian noise, we propose a lightweight corruption compensation module to effectively eliminate residual poisons, providing a more universal defense approach. Extensive experiments demonstrate that our defense approach outperforms 10 state-of-the-art defenses. We also propose an adaptive attack against ECLIPSE and verify the robustness of our defense scheme. Our code is available at https://github.com/CGCL-codes/ECLIPSE.

Tianyuan Zhang, Lu Wang, Xinwei Zhang et al.

Vision-language models (VLMs) have significantly advanced autonomous driving (AD) by enhancing reasoning capabilities. However, these models remain highly vulnerable to adversarial attacks. While existing research has primarily focused on general VLM attacks, the development of attacks tailored to the safety-critical AD context has been largely overlooked. In this paper, we take the first step toward designing adversarial attacks specifically targeting VLMs in AD, exposing the substantial risks these attacks pose within this critical domain. We identify two unique challenges for effective adversarial attacks on AD VLMs: the variability of textual instructions and the time-series nature of visual scenarios. To this end, we propose ADvLM, the first visual adversarial attack framework specifically designed for VLMs in AD. Our framework introduces Semantic-Invariant Induction, which uses a large language model to create a diverse prompt library of textual instructions with consistent semantic content, guided by semantic entropy. Building on this, we introduce Scenario-Associated Enhancement, an approach where attention mechanisms select key frames and perspectives within driving scenarios to optimize adversarial perturbations that generalize across the entire scenario. Extensive experiments on several AD VLMs over multiple benchmarks show that ADvLM achieves state-of-the-art attack effectiveness. Moreover, real-world attack studies further validate its applicability and potential in practice.

Ziqi Zhou, Minghui Li, Wei Liu et al.

With the evolution of self-supervised learning, the pre-training paradigm has emerged as a predominant solution within the deep learning landscape. Model providers furnish pre-trained encoders designed to function as versatile feature extractors, enabling downstream users to harness the benefits of expansive models with minimal effort through fine-tuning. Nevertheless, recent works have exposed a vulnerability in pre-trained encoders, highlighting their susceptibility to downstream-agnostic adversarial examples (DAEs) meticulously crafted by attackers. The lingering question pertains to the feasibility of fortifying the robustness of downstream models against DAEs, particularly in scenarios where the pre-trained encoders are publicly accessible to the attackers. In this paper, we initially delve into existing defensive mechanisms against adversarial examples within the pre-training paradigm. Our findings reveal that the failure of current defenses stems from the domain shift between pre-training data and downstream tasks, as well as the sensitivity of encoder parameters. In response to these challenges, we propose Genetic Evolution-Nurtured Adversarial Fine-tuning (Gen-AF), a two-stage adversarial fine-tuning approach aimed at enhancing the robustness of downstream models. Our extensive experiments, conducted across ten self-supervised training methods and six datasets, demonstrate that Gen-AF attains high testing accuracy and robust testing accuracy against state-of-the-art DAEs.

Xianlong Wang, Hewen Pan, Hangtao Zhang et al.

Robotic manipulation in the physical world is increasingly empowered by \textit{large language models} (LLMs) and \textit{vision-language models} (VLMs), leveraging their understanding and perception capabilities. Recently, various attacks against such robotic policies have been proposed, with backdoor attacks drawing considerable attention for their high stealth and strong persistence capabilities. However, existing backdoor efforts are limited to simulators and suffer from physical-world realization. To address this, we propose \textit{TrojanRobot}, a highly stealthy and broadly effective robotic backdoor attack in the physical world. Specifically, we introduce a module-poisoning approach by embedding a backdoor module into the modular robotic policy, enabling backdoor control over the policy's visual perception module thereby backdooring the entire robotic policy. Our vanilla implementation leverages a backdoor-finetuned VLM to serve as the backdoor module. To enhance its generalization in physical environments, we propose a prime implementation, leveraging the LVLM-as-a-backdoor paradigm and developing three types of prime attacks, \ie, \textit{permutation}, \textit{stagnation}, and \textit{intentional} attacks, thus achieving finer-grained backdoors. Extensive experiments on the UR3e manipulator with 18 task instructions using robotic policies based on four VLMs demonstrate the broad effectiveness and physical-world stealth of TrojanRobot. Our attack's video demonstrations are available via a github link https://trojanrobot.github.io.

Yichen Wang, Yuxuan Chou, Ziqi Zhou et al.

As deep neural networks (DNNs) are widely applied in the physical world, many researches are focusing on physical-world adversarial examples (PAEs), which introduce perturbations to inputs and cause the model's incorrect outputs. However, existing PAEs face two challenges: unsatisfactory attack performance (i.e., poor transferability and insufficient robustness to environment conditions), and difficulty in balancing attack effectiveness with stealthiness, where better attack effectiveness often makes PAEs more perceptible. In this paper, we explore a novel perturbation-based method to overcome the challenges. For the first challenge, we introduce a strategy Deceptive RF injection based on robust features (RFs) that are predictive, robust to perturbations, and consistent across different models. Specifically, it improves the transferability and robustness of PAEs by covering RFs of other classes onto the predictive features in clean images. For the second challenge, we introduce another strategy Adversarial Semantic Pattern Minimization, which removes most perturbations and retains only essential adversarial patterns in AEsBased on the two strategies, we design our method Robust Feature Coverage Attack (RFCoA), comprising Robust Feature Disentanglement and Adversarial Feature Fusion. In the first stage, we extract target class RFs in feature space. In the second stage, we use attention-based feature fusion to overlay these RFs onto predictive features of clean images and remove unnecessary perturbations. Experiments show our method's superior transferability, robustness, and stealthiness compared to existing state-of-the-art methods. Additionally, our method's effectiveness can extend to Large Vision-Language Models (LVLMs), indicating its potential applicability to more complex tasks.

Ziqi Zhou, Bowen Li, Yufei Song et al.

With the advancement of deep learning, object detectors (ODs) with various architectures have achieved significant success in complex scenarios like autonomous driving. Previous adversarial attacks against ODs have been focused on designing customized attacks targeting their specific structures (e.g., NMS and RPN), yielding some results but simultaneously constraining their scalability. Moreover, most efforts against ODs stem from image-level attacks originally designed for classification tasks, resulting in redundant computations and disturbances in object-irrelevant areas (e.g., background). Consequently, how to design a model-agnostic efficient attack to comprehensively evaluate the vulnerabilities of ODs remains challenging and unresolved. In this paper, we propose NumbOD, a brand-new spatial-frequency fusion attack against various ODs, aimed at disrupting object detection within images. We directly leverage the features output by the OD without relying on its internal structures to craft adversarial examples. Specifically, we first design a dual-track attack target selection strategy to select high-quality bounding boxes from OD outputs for targeting. Subsequently, we employ directional perturbations to shift and compress predicted boxes and change classification results to deceive ODs. Additionally, we focus on manipulating the high-frequency components of images to confuse ODs' attention on critical objects, thereby enhancing the attack efficiency. Our extensive experiments on nine ODs and two datasets show that NumbOD achieves powerful attack performance and high stealthiness.

Yufei Song, Ziqi Zhou, Minghui Li et al.

With the rapid advancement of deep learning, the model robustness has become a significant research hotspot, \ie, adversarial attacks on deep neural networks. Existing works primarily focus on image classification tasks, aiming to alter the model's predicted labels. Due to the output complexity and deeper network architectures, research on adversarial examples for segmentation models is still limited, particularly for universal adversarial perturbations. In this paper, we propose a novel universal adversarial attack method designed for segmentation models, which includes dual feature separation and low-frequency scattering modules. The two modules guide the training of adversarial examples in the pixel and frequency space, respectively. Experiments demonstrate that our method achieves high attack success rates surpassing the state-of-the-art methods, and exhibits strong transferability across different models.

Hangtao Zhang, Yichen Wang, Shihui Yan et al.

Object detection models are vulnerable to backdoor attacks, where attackers poison a small subset of training samples by embedding a predefined trigger to manipulate prediction. Detecting poisoned samples (i.e., those containing triggers) at test time can prevent backdoor activation. However, unlike image classification tasks, the unique characteristics of object detection -- particularly its output of numerous objects -- pose fresh challenges for backdoor detection. The complex attack effects (e.g., "ghost" object emergence or "vanishing" object) further render current defenses fundamentally inadequate. To this end, we design TRAnsformation Consistency Evaluation (TRACE), a brand-new method for detecting poisoned samples at test time in object detection. Our journey begins with two intriguing observations: (1) poisoned samples exhibit significantly more consistent detection results than clean ones across varied backgrounds. (2) clean samples show higher detection consistency when introduced to different focal information. Based on these phenomena, TRACE applies foreground and background transformations to each test sample, then assesses transformation consistency by calculating the variance in objects confidences. TRACE achieves black-box, universal backdoor detection, with extensive experiments showing a 30% improvement in AUROC over state-of-the-art defenses and resistance to adaptive attacks.

Wei Wan, Yuxuan Ning, Shengshan Hu et al.

\textit{Federated learning} (FL) and \textit{split learning} (SL) are prevailing distributed paradigms in recent years. They both enable shared global model training while keeping data localized on users' devices. The former excels in parallel execution capabilities, while the latter enjoys low dependence on edge computing resources and strong privacy protection. \textit{Split federated learning} (SFL) combines the strengths of both FL and SL, making it one of the most popular distributed architectures. Furthermore, a recent study has claimed that SFL exhibits robustness against poisoning attacks, with a fivefold improvement compared to FL in terms of robustness. In this paper, we present a novel poisoning attack known as MISA. It poisons both the top and bottom models, causing a \textbf{\underline{misa}}lignment in the global model, ultimately leading to a drastic accuracy collapse. This attack unveils the vulnerabilities in SFL, challenging the conventional belief that SFL is robust against poisoning attacks. Extensive experiments demonstrate that our proposed MISA poses a significant threat to the availability of SFL, underscoring the imperative for academia and industry to accord this matter due attention.

Lulu Xue, Shengshan Hu, Ruizhi Zhao et al.

Collaborative learning (CL) is a distributed learning framework that aims to protect user privacy by allowing users to jointly train a model by sharing their gradient updates only. However, gradient inversion attacks (GIAs), which recover users' training data from shared gradients, impose severe privacy threats to CL. Existing defense methods adopt different techniques, e.g., differential privacy, cryptography, and perturbation defenses, to defend against the GIAs. Nevertheless, all current defense methods suffer from a poor trade-off between privacy, utility, and efficiency. To mitigate the weaknesses of existing solutions, we propose a novel defense method, Dual Gradient Pruning (DGP), based on gradient pruning, which can improve communication efficiency while preserving the utility and privacy of CL. Specifically, DGP slightly changes gradient pruning with a stronger privacy guarantee. And DGP can also significantly improve communication efficiency with a theoretical analysis of its convergence and generalization. Our extensive experiments show that DGP can effectively defend against the most powerful GIAs and reduce the communication cost without sacrificing the model's utility.

Yufei Song, Ziqi Zhou, Qi Lu et al.

Segmentation models exhibit significant vulnerability to adversarial examples in white-box settings, but existing adversarial attack methods often show poor transferability across different segmentation models. While some researchers have explored transfer-based adversarial attack (i.e., transfer attack) methods for segmentation models, the complex contextual dependencies within these models and the feature distribution gaps between surrogate and target models result in unsatisfactory transfer success rates. To address these issues, we propose SegTrans, a novel transfer attack framework that divides the input sample into multiple local regions and remaps their semantic information to generate diverse enhanced samples. These enhanced samples replace the original ones for perturbation optimization, thereby improving the transferability of adversarial examples across different segmentation models. Unlike existing methods, SegTrans only retains local semantic information from the original input, rather than using global semantic information to optimize perturbations. Extensive experiments on two benchmark datasets, PASCAL VOC and Cityscapes, four different segmentation models, and three backbone networks show that SegTrans significantly improves adversarial transfer success rates without introducing additional computational overhead. Compared to the current state-of-the-art methods, SegTrans achieves an average increase of 8.55% in transfer attack success rate and improves computational efficiency by more than 100%.

Ziqi Zhou, Menghao Deng, Yufei Song et al.

Benefiting from its superior feature learning capabilities and efficiency, deep hashing has achieved remarkable success in large-scale image retrieval. Recent studies have demonstrated the vulnerability of deep hashing models to backdoor attacks. Although these studies have shown promising attack results, they rely on access to the training dataset to implant the backdoor. In the real world, obtaining such data (e.g., identity information) is often prohibited due to privacy protection and intellectual property concerns. Embedding backdoors into deep hashing models without access to the training data, while maintaining retrieval accuracy for the original task, presents a novel and challenging problem. In this paper, we propose DarkHash, the first data-free backdoor attack against deep hashing. Specifically, we design a novel shadow backdoor attack framework with dual-semantic guidance. It embeds backdoor functionality and maintains original retrieval accuracy by fine-tuning only specific layers of the victim model using a surrogate dataset. We consider leveraging the relationship between individual samples and their neighbors to enhance backdoor attacks during training. By designing a topological alignment loss, we optimize both individual and neighboring poisoned samples toward the target sample, further enhancing the attack capability. Experimental results on four image datasets, five model architectures, and two hashing methods demonstrate the high effectiveness of DarkHash, outperforming existing state-of-the-art backdoor attack methods. Defense experiments show that DarkHash can withstand existing mainstream backdoor defense methods.

Yechao Zhang, Yingzhe Xu, Junyu Shi et al.

Deep neural networks (DNNs) are susceptible to universal adversarial perturbations (UAPs). These perturbations are meticulously designed to fool the target model universally across all sample classes. Unlike instance-specific adversarial examples (AEs), generating UAPs is more complex because they must be generalized across a wide range of data samples and models. Our research reveals that existing universal attack methods, which optimize UAPs using DNNs with static model parameter snapshots, do not fully leverage the potential of DNNs to generate more effective UAPs. Rather than optimizing UAPs against static DNN models with a fixed training set, we suggest using dynamic model-data pairs to generate UAPs. In particular, we introduce a dynamic maximin optimization strategy, aiming to optimize the UAP across a variety of optimal model-data pairs. We term this approach DM-UAP. DM-UAP utilizes an iterative max-min-min optimization framework that refines the model-data pairs, coupled with a curriculum UAP learning algorithm to examine the combined space of model parameters and data thoroughly. Comprehensive experiments on the ImageNet dataset demonstrate that the proposed DM-UAP markedly enhances both cross-sample universality and cross-model transferability of UAPs. Using only 500 samples for UAP generation, DM-UAP outperforms the state-of-the-art approach with an average increase in fooling ratio of 12.108%.

Minghui Li, Zikang Guo, Yang Wu et al.

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant approach for estimating the binding strength between drugs and target proteins. However, existing methods simply utilize the drug's local information from molecular topology rather than global information. Additionally, the features of drugs and proteins are usually fused with a simple concatenation operation, limiting their effectiveness. To address these challenges, we proposed ViDTA, an enhanced DTA prediction framework. We introduce virtual nodes into the Graph Neural Network (GNN)-based drug feature extraction network, which acts as a global memory to exchange messages more efficiently. By incorporating virtual graph nodes, we seamlessly integrate local and global features of drug molecular structures, expanding the GNN's receptive field. Additionally, we propose an attention-based linear feature fusion network for better capturing the interaction information between drugs and proteins. Experimental results evaluated on various benchmarks including Davis, Metz, and KIBA demonstrate that our proposed ViDTA outperforms the state-of-the-art baselines.

Wei Wan, Yuxuan Ning, Zhicong Huang et al.

Federated Learning (FL) is a distributed paradigm aimed at protecting participant data privacy by exchanging model parameters to achieve high-quality model training. However, this distributed nature also makes FL highly vulnerable to backdoor attacks. Notably, the recently proposed state-of-the-art (SOTA) attack, 3DFed (SP2023), uses an indicator mechanism to determine whether the backdoor models have been accepted by the defender and adaptively optimizes backdoor models, rendering existing defenses ineffective. In this paper, we first reveal that the failure of existing defenses lies in the employment of empirical statistical measures that are loosely coupled with backdoor attacks. Motivated by this, we propose a Malignity-Aware backdooR defenSe (MARS) that leverages backdoor energy (BE) to indicate the malicious extent of each neuron. To amplify malignity, we further extract the most prominent BE values from each model to form a concentrated backdoor energy (CBE). Finally, a novel Wasserstein distance-based clustering method is introduced to effectively identify backdoor models. Extensive experiments demonstrate that MARS can defend against SOTA backdoor attacks and significantly outperforms existing defenses.

Xiaomei Zhang, Zhaoxi Zhang, Yanjun Zhang et al.

Textual adversarial examples pose serious threats to the reliability of natural language processing systems. Recent studies suggest that adversarial examples tend to deviate from the underlying manifold of normal texts, whereas pre-trained masked language models can approximate the manifold of normal data. These findings inspire the exploration of masked language models for detecting textual adversarial attacks. We first introduce Masked Language Model-based Detection (MLMD), leveraging the mask and unmask operations of the masked language modeling (MLM) objective to induce the difference in manifold changes between normal and adversarial texts. Although MLMD achieves competitive detection performance, its exhaustive one-by-one masking strategy introduces significant computational overhead. Our posterior analysis reveals that a significant number of non-keywords in the input are not important for detection but consume resources. Building on this, we introduce Gradient-guided MLMD (GradMLMD), which leverages gradient information to identify and skip non-keywords during detection, significantly reducing resource consumption without compromising detection performance.

Yechao Zhang, Yuxuan Zhou, Tianyu Li et al.

Transfer learning from pre-trained encoders has become essential in modern machine learning, enabling efficient model adaptation across diverse tasks. However, this combination of pre-training and downstream adaptation creates an expanded attack surface, exposing models to sophisticated backdoor embeddings at both the encoder and dataset levels--an area often overlooked in prior research. Additionally, the limited computational resources typically available to users of pre-trained encoders constrain the effectiveness of generic backdoor defenses compared to end-to-end training from scratch. In this work, we investigate how to mitigate potential backdoor risks in resource-constrained transfer learning scenarios. Specifically, we conduct an exhaustive analysis of existing defense strategies, revealing that many follow a reactive workflow based on assumptions that do not scale to unknown threats, novel attack types, or different training paradigms. In response, we introduce a proactive mindset focused on identifying clean elements and propose the Trusted Core (T-Core) Bootstrapping framework, which emphasizes the importance of pinpointing trustworthy data and neurons to enhance model security. Our empirical evaluations demonstrate the effectiveness and superiority of T-Core, specifically assessing 5 encoder poisoning attacks, 7 dataset poisoning attacks, and 14 baseline defenses across five benchmark datasets, addressing four scenarios of 3 potential backdoor threats.

Dezhong Yao, Sanmu Li, Yutong Dai et al.

Federated continual learning (FCL) has received increasing attention due to its potential in handling real-world streaming data, characterized by evolving data distributions and varying client classes over time. The constraints of storage limitations and privacy concerns confine local models to exclusively access the present data within each learning cycle. Consequently, this restriction induces performance degradation in model training on previous data, termed "catastrophic forgetting". However, existing FCL approaches need to identify or know changes in data distribution, which is difficult in the real world. To release these limitations, this paper directs attention to a broader continuous framework. Within this framework, we introduce Federated Bayesian Neural Network (FedBNN), a versatile and efficacious framework employing a variational Bayesian neural network across all clients. Our method continually integrates knowledge from local and historical data distributions into a single model, adeptly learning from new data distributions while retaining performance on historical distributions. We rigorously evaluate FedBNN's performance against prevalent methods in federated learning and continual learning using various metrics. Experimental analyses across diverse datasets demonstrate that FedBNN achieves state-of-the-art results in mitigating forgetting.

Yichen Wang, Hangtao Zhang, Hewen Pan et al.

Vision-Language Models (VLMs), with their strong reasoning and planning capabilities, are widely used in embodied decision-making (EDM) tasks in embodied agents, such as autonomous driving and robotic manipulation. Recent research has increasingly explored adversarial attacks on VLMs to reveal their vulnerabilities. However, these attacks either rely on overly strong assumptions, requiring full knowledge of the victim VLM, which is impractical for attacking VLM-based agents, or exhibit limited effectiveness. The latter stems from disrupting most semantic information in the image, which leads to a misalignment between the perception and the task context defined by system prompts. This inconsistency interrupts the VLM's reasoning process, resulting in invalid outputs that fail to affect interactions in the physical world. To this end, we propose a fine-grained adversarial attack framework, ADVEDM, which modifies the VLM's perception of only a few key objects while preserving the semantics of the remaining regions. This attack effectively reduces conflicts with the task context, making VLMs output valid but incorrect decisions and affecting the actions of agents, thus posing a more substantial safety threat in the physical world. We design two variants of based on this framework, ADVEDM-R and ADVEDM-A, which respectively remove the semantics of a specific object from the image and add the semantics of a new object into the image. The experimental results in both general scenarios and EDM tasks demonstrate fine-grained control and excellent attack performance.

Peijin Guo, Minghui Li, Hewen Pan et al.

Accurate prediction of molecular metabolic stability (MS) is critical for drug research and development but remains challenging due to the complex interplay of molecular interactions. Despite recent advances in graph neural networks (GNNs) for MS prediction, current approaches face two critical limitations: (1) incomplete molecular modeling due to atom-centric message-passing mechanisms that disregard bond-level topological features, and (2) prediction frameworks that lack reliable uncertainty quantification. To address these challenges, we propose TrustworthyMS, a novel contrastive learning framework designed for uncertainty-aware metabolic stability prediction. First, a molecular graph topology remapping mechanism synchronizes atom-bond interactions through edge-induced feature propagation, capturing both localized electronic effects and global conformational constraints. Second, contrastive topology-bond alignment enforces consistency between molecular topology views and bond patterns via feature alignment, enhancing representation robustness. Third, uncertainty modeling through Beta-Binomial uncertainty quantification enables simultaneous prediction and confidence calibration under epistemic uncertainty. Through extensive experiments, our results demonstrate that TrustworthyMS outperforms current state-of-the-art methods in terms of predictive performance.

Minghui Li, Hao Zhang, Yechao Zhang et al.

Direct Prompt Injection (DPI) attacks pose a critical security threat to Large Language Models (LLMs) due to their low barrier of execution and high potential damage. To address the impracticality of existing white-box/gray-box methods and the poor transferability of black-box methods, we propose an activations-guided prompt injection attack framework. We first construct an Energy-based Model (EBM) using activations from a surrogate model to evaluate the quality of adversarial prompts. Guided by the trained EBM, we employ the token-level Markov Chain Monte Carlo (MCMC) sampling to adaptively optimize adversarial prompts, thereby enabling gradient-free black-box attacks. Experimental results demonstrate our superior cross-model transferability, achieving 49.6% attack success rate (ASR) across five mainstream LLMs and 34.6% improvement over human-crafted prompts, and maintaining 36.6% ASR on unseen task scenarios. Interpretability analysis reveals a correlation between activations and attack effectiveness, highlighting the critical role of semantic patterns in transferable vulnerability exploitation.

Hangtao Zhang, Shengshan Hu, Yichen Wang et al.

Object detection tasks, crucial in safety-critical systems like autonomous driving, focus on pinpointing object locations. These detectors are known to be susceptible to backdoor attacks. However, existing backdoor techniques have primarily been adapted from classification tasks, overlooking deeper vulnerabilities specific to object detection. This paper is dedicated to bridging this gap by introducing Detector Collapse} (DC), a brand-new backdoor attack paradigm tailored for object detection. DC is designed to instantly incapacitate detectors (i.e., severely impairing detector's performance and culminating in a denial-of-service). To this end, we develop two innovative attack schemes: Sponge for triggering widespread misidentifications and Blinding for rendering objects invisible. Remarkably, we introduce a novel poisoning strategy exploiting natural objects, enabling DC to act as a practical backdoor in real-world environments. Our experiments on different detectors across several benchmarks show a significant improvement ($\sim$10\%-60\% absolute and $\sim$2-7$\times$ relative) in attack efficacy over state-of-the-art attacks.

Junyu Shi, Wei Wan, Shengshan Hu et al.

Recently emerged federated learning (FL) is an attractive distributed learning framework in which numerous wireless end-user devices can train a global model with the data remained autochthonous. Compared with the traditional machine learning framework that collects user data for centralized storage, which brings huge communication burden and concerns about data privacy, this approach can not only save the network bandwidth but also protect the data privacy. Despite the promising prospect, byzantine attack, an intractable threat in conventional distributed network, is discovered to be rather efficacious against FL as well. In this paper, we conduct a comprehensive investigation of the state-of-the-art strategies for defending against byzantine attacks in FL. We first provide a taxonomy for the existing defense solutions according to the techniques they used, followed by an across-the-board comparison and discussion. Then we propose a new byzantine attack method called weight attack to defeat those defense schemes, and conduct experiments to demonstrate its threat. The results show that existing defense solutions, although abundant, are still far from fully protecting FL. Finally, we indicate possible countermeasures for weight attack, and highlight several challenges and future research directions for mitigating byzantine attacks in FL.

Minghui Li, Sherman S. M. Chow, Shengshan Hu et al.

Convolutional neural network is a machine-learning model widely applied in various prediction tasks, such as computer vision and medical image analysis. Their great predictive power requires extensive computation, which encourages model owners to host the prediction service in a cloud platform. Recent researches focus on the privacy of the query and results, but they do not provide model privacy against the model-hosting server and may leak partial information about the results. Some of them further require frequent interactions with the querier or heavy computation overheads, which discourages querier from using the prediction service. This paper proposes a new scheme for privacy-preserving neural network prediction in the outsourced setting, i.e., the server cannot learn the query, (intermediate) results, and the model. Similar to SecureML (S&P'17), a representative work that provides model privacy, we leverage two non-colluding servers with secret sharing and triplet generation to minimize the usage of heavyweight cryptography. Further, we adopt asynchronous computation to improve the throughput, and design garbled circuits for the non-polynomial activation function to keep the same accuracy as the underlying network (instead of approximating it). Our experiments on MNIST dataset show that our scheme achieves an average of 122x, 14.63x, and 36.69x reduction in latency compared to SecureML, MiniONN (CCS'17), and EzPC (EuroS&P'19), respectively. For the communication costs, our scheme outperforms SecureML by 1.09x, MiniONN by 36.69x, and EzPC by 31.32x on average. On the CIFAR dataset, our scheme achieves a lower latency by a factor of 7.14x and 3.48x compared to MiniONN and EzPC, respectively. Our scheme also provides 13.88x and 77.46x lower communication costs than MiniONN and EzPC on the CIFAR dataset.

Lingchen Zhao, Shengshan Hu, Qian Wang et al.

Collaborative learning allows multiple clients to train a joint model without sharing their data with each other. Each client performs training locally and then submits the model updates to a central server for aggregation. Since the server has no visibility into the process of generating the updates, collaborative learning is vulnerable to poisoning attacks where a malicious client can generate a poisoned update to introduce backdoor functionality to the joint model. The existing solutions for detecting poisoned updates, however, fail to defend against the recently proposed attacks, especially in the non-IID setting. In this paper, we present a novel defense scheme to detect anomalous updates in both IID and non-IID settings. Our key idea is to realize client-side cross-validation, where each update is evaluated over other clients' local data. The server will adjust the weights of the updates based on the evaluation results when performing aggregation. To adapt to the unbalanced distribution of data in the non-IID setting, a dynamic client allocation mechanism is designed to assign detection tasks to the most suitable clients. During the detection process, we also protect the client-level privacy to prevent malicious clients from stealing the training data of other clients, by integrating differential privacy with our design without degrading the detection performance. Our experimental evaluations on two real-world datasets show that our scheme is significantly robust to two representative poisoning attacks.

Shengshan Hu, Chengjun Cai, Qian Wang et al.

Searchable symmetric encryption (SSE) allows the data owner to outsource an encrypted database to a remote server in a private manner while maintaining the ability for selectively search. So far, most existing solutions focus on an honest-but-curious server, while security designs against a malicious server have not drawn enough attention. A few recent works have attempted to construct verifiable SSE that enables the data owner to verify the integrity of search results. Nevertheless, these verification mechanisms are highly dependent on specific SSE schemes, and fail to support complex queries. A general verification mechanism is desired that can be applied to all SSE schemes. In this work, instead of concentrating on a central server, we explore the potential of the smart contract, an emerging blockchain-based decentralized technology, and construct decentralized SSE schemes where the data owner can receive correct search results with assurance without worrying about potential wrongdoings of a malicious server. We study both public and private blockchain environments and propose two designs with a trade-off between security and efficiency. To better support practical applications, the multi-user setting of SSE is further investigated where the data owner allows authenticated users to search keywords in shared documents. We implement prototypes of our two designs and present experiments and evaluations to demonstrate the practicability of our decentralized SSE schemes.