Parham Saremi

Saeed Saadatnejad, Mehrshad Mirmohammadi, Matin Daghyani et al.

Recently, there has been an arms race of pose forecasting methods aimed at solving the spatio-temporal task of predicting a sequence of future 3D poses of a person given a sequence of past observed ones. However, the lack of unified benchmarks and limited uncertainty analysis have hindered progress in the field. To address this, we first develop an open-source library for human pose forecasting, including multiple models, supporting several datasets, and employing standardized evaluation metrics, with the aim of promoting research and moving toward a unified and consistent evaluation. Second, we devise two types of uncertainty in the problem to increase performance and convey better trust: 1) we propose a method for modeling aleatoric uncertainty by using uncertainty priors to inject knowledge about the pattern of uncertainty. This focuses the capacity of the model in the direction of more meaningful supervision while reducing the number of learned parameters and improving stability; 2) we introduce a novel approach for quantifying the epistemic uncertainty of any model through clustering and measuring the entropy of its assignments. Our experiments demonstrate up to $25\%$ improvements in forecasting at short horizons, with no loss on longer horizons on Human3.6M, AMSS, and 3DPW datasets, and better performance in uncertainty estimation. The code is available online at https://github.com/vita-epfl/UnPOSed.

Parham Saremi, Amar Kumar, Mohamed Mohamed et al.

Vision-Language Foundation Models (VLFM) have shown a tremendous increase in performance in terms of generating high-resolution, photorealistic natural images. While VLFMs show a rich understanding of semantic content across modalities, they often struggle with fine-grained alignment tasks that require precise correspondence between image regions and textual descriptions, a limitation in medical imaging, where accurate localization and detection of clinical features are essential for diagnosis and analysis. To address this issue, we propose a multi-stage architecture where a pre-trained VLFM (e.g. Stable Diffusion) provides a cursory semantic understanding, while a reinforcement learning (RL) algorithm refines the alignment through an iterative process that optimizes for understanding semantic context. The reward signal is designed to align the semantic information of the text with synthesized images. Experiments on the public ISIC2019 skin lesion dataset demonstrate that the proposed method improves (a) the quality of the generated images, and (b) the alignment with the text prompt over the original fine-tuned Stable Diffusion baseline. We also show that the synthesized samples could be used to improve disease classifier performance for underrepresented subgroups through augmentation. Our code is accessible through the project website: https://parhamsaremi.github.io/rl4med-ddpo

Gian Mario Favero, Parham Saremi, Emily Kaczmarek et al.

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and training techniques to ensure safe and reliable deployment. Recently, diffusion models have become synonymous with generative modeling in 2D. These models showcase robustness across a range of tasks including natural image classification, where classification is performed by comparing reconstruction errors across images generated for each possible conditioning input. This work presents the first exploration of the potential of class conditional diffusion models for 2D medical image classification. First, we develop a novel majority voting scheme shown to improve the performance of medical diffusion classifiers. Next, extensive experiments on the CheXpert and ISIC Melanoma skin cancer datasets demonstrate that foundation and trained-from-scratch diffusion models achieve competitive performance against SOTA discriminative classifiers without the need for explicit supervision. In addition, we show that diffusion classifiers are intrinsically explainable, and can be used to quantify the uncertainty of their predictions, increasing their trustworthiness and reliability in safety-critical, clinical contexts. Further information is available on our project page: https://faverogian.github.io/med-diffusion-classifier.github.io/.

Bailey Trang, Parham Saremi, Alan Q. Wang et al.

Capturing diversity is crucial in conditional and prompt-based image generation, particularly when conditions contain uncertainty that can lead to multiple plausible outputs. To generate diverse images reflecting this diversity, traditional methods often modify random seeds, making it difficult to discern meaningful differences between samples, or diversify the input prompt, which is limited in verbally interpretable diversity. We propose Rainbow, a novel conditional image generation framework, applicable to any pretrained conditional generative model, that addresses inherent condition/prompt uncertainty and generates diverse plausible images. Rainbow is based on a simple yet effective idea: decomposing the input condition into diverse latent representations, each capturing an aspect of the uncertainty and generating a distinct image. First, we integrate a latent graph, parameterized by Generative Flow Networks (GFlowNets), into the prompt representation computation. Second, leveraging GFlowNets' advanced graph sampling capabilities to capture uncertainty and output diverse trajectories over the graph, we produce multiple trajectories that collectively represent the input condition, leading to diverse condition representations and corresponding output images. Evaluations on natural image and medical image datasets demonstrate Rainbow's improvement in both diversity and fidelity across image synthesis, image generation, and counterfactual generation tasks.