Fangrui Huang

Fangrui Huang, Souhad Chbeir, Arpandeep Khatua et al.

Large language models (LLMs) are increasingly used for mental-health support; yet prevailing evaluation methods--fluency metrics, preference tests, and generic dialogue benchmarks--fail to capture the clinically critical dimensions of psychotherapy. We introduce THERAPYGYM, a framework that evaluates and improves therapy chatbots along two clinical pillars: fidelity and safety. Fidelity is measured using the Cognitive Therapy Rating Scale (CTRS), implemented as an automated pipeline that scores adherence to CBT techniques over multi-turn sessions. Safety is assessed using a multi-label annotation scheme, covering therapy-specific risks (e.g., failing to address harm or abuse). To mitigate bias and unreliability in LLM-based judges, we further release THERAPYJUDGEBENCH, a validation set of 116 dialogues with 1,270 expert ratings for auditing and calibration against licensed clinicians. THERAPYGYM also serves as a training harness: CTRS and safety-based rewards drive RL with configurable patient simulations spanning diverse symptom profiles. Models trained in THERAPYGYM improve on expert ratings, with average CTRS rising from 0.10 to 0.60 (and 0.16 to 0.59 under LLM judges). Our work enables scalable development of therapy chatbots that are faithful to evidence-based practice and safer in high-stakes use.

Bailey Trang, Parham Saremi, Alan Q. Wang et al.

Capturing diversity is crucial in conditional and prompt-based image generation, particularly when conditions contain uncertainty that can lead to multiple plausible outputs. To generate diverse images reflecting this diversity, traditional methods often modify random seeds, making it difficult to discern meaningful differences between samples, or diversify the input prompt, which is limited in verbally interpretable diversity. We propose Rainbow, a novel conditional image generation framework, applicable to any pretrained conditional generative model, that addresses inherent condition/prompt uncertainty and generates diverse plausible images. Rainbow is based on a simple yet effective idea: decomposing the input condition into diverse latent representations, each capturing an aspect of the uncertainty and generating a distinct image. First, we integrate a latent graph, parameterized by Generative Flow Networks (GFlowNets), into the prompt representation computation. Second, leveraging GFlowNets' advanced graph sampling capabilities to capture uncertainty and output diverse trajectories over the graph, we produce multiple trajectories that collectively represent the input condition, leading to diverse condition representations and corresponding output images. Evaluations on natural image and medical image datasets demonstrate Rainbow's improvement in both diversity and fidelity across image synthesis, image generation, and counterfactual generation tasks.

Fangrui Huang, Alan Wang, Binxu Li et al.

Deep generative models have demonstrated remarkable success in medical image synthesis. However, ensuring conditioning faithfulness and high-quality synthetic images for direct or counterfactual generation remains a challenge. In this work, we introduce a cycle training framework to fine-tune diffusion models for improved conditioning adherence and enhanced synthetic image realism. Our approach, Cycle Diffusion Model (CDM), enforces consistency between generated and original images by incorporating cycle constraints, enabling more reliable direct and counterfactual generation. Experiments on a combined 3D brain MRI dataset (from ABCD, HCP aging & young adults, ADNI, and PPMI) show that our method improves conditioning accuracy and enhances image quality as measured by FID and SSIM. The results suggest that the cycle strategy used in CDM can be an effective method for refining diffusion-based medical image generation, with applications in data augmentation, counterfactual, and disease progression modeling.